| DC48102 |
Claficapavir |
Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM. Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1. |
|
| DC48103 |
Onradivir |
Onradivir is a significantly better anti-influenza virus agent extracted from patent WO2021047437 A1. |
|
| DC48104 |
RSV-IN-2 |
RSV-IN-2 is a potent dual inhibitor of wild-type and mutant respiratory syncytial virus fusion proteins (wild-type, EC50 = 0.27 nM; D486N-mutant, EC50 = 0.70 nM). |
|
| DC48105 |
Antiviral agent 5 |
Antiviral agent 5 is an intermediate used in antiviral agents targeting 3C and 3CL proteases including SARS-CoV-2 Mpro. |
|
| DC48106 |
MERS-CoV-IN-1 |
MERS-CoV-IN-1 exhibits excellent inhibitory activity against coronavirus. MERS-CoV-IN-1 is useful as a pharmaceutical composition for preventing coronavirus-induced diseases (MERS-CoV and SARS) (extracted from patent WO2018174442A1, compound 1). |
|
| DC48107 |
Ensitrelvir fumarate
Featured
|
Ensitrelvir (S-217622) fumarate is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor (IC50=13 nM). |
|
| DC48382 |
Etimicin sulfate |
Etimicin (sulfate), a fourth-generation aminoglycoside antibiotic, is now widely clinically used due to its high efficacy and low toxicity. |
|
| DC48383 |
Tomaymycin |
Tomaymycin is an antitumor antibiotic. Tomaymycin has antimicrobial activity against Grampositive bacteria. |
|
| DC48407 |
NS5A-IN-1 |
NS5A-IN-1 is a prodrug of the HCV NS5A inhibitor Pibrentasvir (ABT-530). |
|
| DC48408 |
GSK2818713 |
GSK2818713 is a novel Hepatitis C NS5A replication complex inhibitor. |
|
| DC48409 |
AL-611
Featured
|
AL-611 is an HCV NS5B polymerase inhibitor (EC50 = 5 nM). |
|
| DC48415 |
Pirmitegravir |
Pirmitegravir is a potent and first-in-class inhibitor of allosteric integrase (ALLINI) that targets LEDGF/p75 binding site. Pirmitegravir displays picomolar IC50 in human PBMCs with a >24,000 therapeutic index against HIV-1. Pirmitegravir harbors outstanding anti-virus and safety properties. |
|
| DC48416 |
Brecanavir |
Brecanavir (GW640385) is a novel, potent HIV protease inhibitor. |
|
| DC48436 |
Merbromin |
Merbromin (Mercury dibromofluorescein disodium salt, Mercurochrome, Merbromine, Mercurocol, Sodium mercurescein, Asceptichrome, Supercrome, Brocasept, Cinfacromin), a xanthene dye, is a topical antiseptic used for minor cuts and scrapes. Merbromin is an organomercuric disodium salt compound and a fluorescein. Merbromin is a selective inhibitor of 3CLpro and provides a scaffold to design effective inhibitors of SARS-CoV-2. |
|
| DC48490 |
N-(2-hydroxy-2-phenylethyl)acetamide |
N-(2-hydroxy-2-phenylethyl)acetamide is isolated from the solid rice cultures of the endophytic fungus Diaporthe eucalyptorum KY-9. N-(2-hydroxy-2-phenylethyl)acetamide exhibits antifungal activities against Alternaria solani. |
|
| DC48493 |
Policresulen |
Policresulen is a potent inhibitor of DENV2 NS2B/NS3 protease (IC50 of 0.48 μg/mL). Policresulen inhibits DENV2 replication in BHK-21 cells with IC50 of 4.99 μg/mL. Policresulen acts as a competitive inhibitor of the protease, and slightly affects the protease stability. |
|
| DC48503 |
Diethylcarbamazine |
Diethylcarbamazine is a microfilaricidal drug used originally in onchocerciasis and lymphatic filiariasis study. |
|
| DC48520 |
Monaschromone |
Monaschromone, a polyketide metabolite, significantly inhibits the growth of B. cinerea, A. solani, M. oryzae, and G. saubinettii, with the MIC values ranging from 6.25 to 12.5 μM. |
|
| DC48521 |
Streptazolin |
Streptazolin is an antibiotic. Streptazolin increases bacterial killing and elaboration of immunostimulatory cytokines by macrophages in vitro. Streptazolin stimulates the macrophage NF-κB pathway via PI3K signaling. |
|
| DC48523 |
Buclosamide |
Buclosamide is a topical antimycotic agent. |
|
| DC48528 |
Anserinone B |
Anserinone B is an antifungal and antibacterial benzoquinone. Anserinone B causes radial growth reductions of 50% and 37% against S.fimicola and A. furfuraceus, respectively. Anserinones B also displays moderate cytotoxicity in the NCI’s 60 human tumor cell line panel (GI50=4.4 µg/mL). |
|
| DC48529 |
Canadensolide |
Canadensolide is an antifungal metabolite of Penicillium canadense. |
|
| DC48530 |
ETX0462 |
ETX0462 is a gram-negative chemotype antibiotic. ETX0462 has potent in vitro and in vivo activity against Pseudomonas aeruginosa plus all other Gram-negative ESKAPE pathogens, Stenotrophomonas maltophilia and biothreat pathogens. |
|
| DC48533 |
FPI-1602 |
FPI-1602 is a β-lactamase inhibitor. FPI-1602 displays marked antimicrobial activity against P. aeruginosa, E. coli, and Enterobacter spp.. |
|
| DC48579 |
Asperfuran |
Asperfuran is an antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibits chitin synthase from Coprinus cinereus. Asperfuran shows weak cytotoxicity In HeLa S3 and L1210 cells with an IC50 of 25 μg/ml. |
|
| DC48593 |
Norfunalenone |
Norfunalenone exhibits weak cytotoxic activity in mouse myeloma NS-1 cell line (ATCC TIB-18) with an IC50 of 70 μM. Norfunalenone also exhibits weak antibacterial activity against B. subtilis (MIC=100 μg/mL; IC50=265 μM). |
|
| DC48596 |
Pulixin |
Pulixin prevents FREP1 from binding to P. falciparum-infected cell lysate. Pulixin blocks the transmission of the parasite to mosquitoes with an EC50 of 11 µM. Pulixin also inhibits the proliferation of asexual-stage P. falciparum with an EC50 of 47 nM. |
|
| DC48603 |
Chaetosemin J |
Chaetosemin J, an antifungal metabolite, exhibits inhibitory activity against plant pathogenic fungi Botrytis cinerea, Alternaria solani, Magnaporthe oryzae, and Gibberella saubinettii, with MIC values ranging from 12.5-25 μM. |
|
| DC48604 |
Cefetamet |
Cefetamet is a cephalosporin antibiotic. Cefetamet has the potential for the research of both upper and lower community-acquired respiratory tract infections. |
|
| DC48609 |
Asperaculane B |
Asperaculane B is a fungal metabolite against P. falciparum transmission with an IC50 of 7.89 µM. Asperaculane B also inhibits the development of asexual P. falciparum with IC50 of 3 µM, and it is nontoxic to human cells. |
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