| DC49431 |
Antibacterial agent 74 |
Antibacterial agent 74 (compound 36) is an anti-Salmonella agent. |
|
| DC49432 |
Talaromycesone A |
Talaromycesone A is an oxaphenalenone dimer compound. Talaromycesone A exhibits potent antibacterial activities with an IC50 of 3.70 μM, against human pathogenic Staphylococcus strains. Talaromycesone A displays potent acetylcholinesterase inhibitory activities with an IC50 of 7.49 μM. |
|
| DC49433 |
Kumbicin C |
Kumbicin C is a bis-indolyl benzenoid compound from an Australian soil fungus, Aspergillus kumbius. Kumbicin C inhibits the growth of mouse myeloma cells and the Gram-positive bacterium Bacillus subtilis. |
|
| DC49435 |
Anticancer agent 34 |
Anticancer agent 34 (compound 9), a sulfonylurea derivative, is a potent antimicrobial and anticancer agent. Anticancer agent 34 inhibits the microbial growth of B. mycoides, E. coli, and C. albicans with a MIC between 0.156 and 0.039 mg/ml. Anticancer agent 34 inhibits A549, PC3 cell growth with IC50s of 8.4 µg/ml, 7.8 µg/ml, respectively. |
|
| DC49436 |
Pachybasin |
Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively. |
|
| DC49437 |
epi-Equisetin |
epi-Equisetin, a secondary metabolite, has antibacterial activity. |
|
| DC49438 |
c[Arg-Arg-Arg-Arg-Dip-Dip-Dip] |
c[Arg-Arg-Arg-Arg-Dip-Dip-Dip] (Compound 8C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 12.5 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively. |
|
| DC49439 |
c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] |
c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] (Compound 9C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 25 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively. |
|
| DC49440 |
Monocerin |
Monocerin is an isocoumarin derivative. Monocerin is isolated from Microdochium bolleyi, an endophytic fungus from Fagonia cretica. Monocerin shows good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca. |
|
| DC49441 |
Poly(hexamethylenebiguanide) hydrochloride |
Poly(hexamethylenebiguanide) hydrochloride is an antimicrobial agent, which can be used in medical, apparel, and household textile sectors. |
|
| DC49442 |
4-Piperidinecarboxamide |
4-Piperidinecarboxamide is a mycobacterial aspartyl-tRNA synthetase (AspS) inhibitor. 4-Piperidinecarboxamide is a promising anti-tuberculosis (TB) agent. |
|
| DC49443 |
Antibacterial agent 64 |
Antibacterial agent 64 is a potent YycG inhibitor (IC50=6.1 µM) and an antibacterial agent. Antibacterial agent 64 combines with ampicillin could synergistically eradicate the biofilm-embedded viable bacteria. |
|
| DC49444 |
Radicinol |
Radicinol is a metabolite of cochliobolus lunata, and absolute stereochemistry of radicinin. |
|
| DC49445 |
Antibacterial agent 27 |
Antibacterial agent 27 is a potent antibacterial compound against Candida species. |
|
| DC49446 |
Antibacterial agent 26 |
Antibacterial agent 26 is a potent antibacterial compound. |
|
| DC49447 |
Sulfisoxazole acetyl |
Sulfisoxazole acetyl (N1-Acetylsulfisoxazole), a Sulfisoxazole derivative, is an orally active dihydropteroate synthase inhibitor. Sulfisoxazole acetyl has an antibacterial action. |
|
| DC49448 |
DprE1-IN-1 |
DprE1-IN-1 is a potent, orally active DprE1 inhibitor with favorable hepatocyte stability, low cytotoxicity and low hERG channel inhibition. DprE1-IN-1 displays potent activity against both drug-susceptible and clinically isolated drug-resistant Tuberculosis strains with MICs<0.1 μg/mL, as well as good intracellular antimycobacterial activity with a 1.29 log10 CFU reduction in macrophages. |
|
| DC49449 |
Anticancer agent 36 |
Anticancer agent 36 (compound 11), a sulfonylurea derivative, is a potent antimicrobial and anticancer agent. Anticancer agent 36 inhibits the microbial growth of B. mycoides, E. coli, and C. albicans with a MIC between 0.156 and 0.039 mg/L. Anticancer agent 36 inhibits A549, PC3 cell growth with IC50s of 19.7 µg/mL, 11.9 µg/mL, respectively. |
|
| DC49450 |
Antibacterial agent 75 |
Antibacterial agent 75 (compound 24) is an antibacterial agent. Antibacterial agent 75 (compound 24) is able to re-sensitize VRSA to vancomycin. |
|
| DC49451 |
Antibacterial agent 82 |
Antibacterial agent 82 (compound 7p) is an antibacterial agent. |
|
| DC49452 |
Antibacterial agent 76 |
Antibacterial agent 76 (compound 9) is an antibacterial agent. |
|
| DC49453 |
Antibacterial agent 77 |
Antibacterial agent 77 (compound 12) is an antibacterial agent. |
|
| DC49454 |
Antibacterial agent 79 |
Antibacterial agent 79 (compound 32) is an antibacterial agent. |
|
| DC49455 |
Antibacterial agent 80 |
Antibacterial agent 80 (compound 20) is an antibacterial agent. |
|
| DC49456 |
RmlA-IN-2 |
RmlA-IN-2 (Compound 1d) is a potent inhibitor of glucose-1-phosphate thymidylyltransferase (RmlA) with an IC50 of 0.303 μM. RmlA-IN-2 influences monosaccharide l-Rhamnose biosynthetic pathway. RmlA-IN-2 affects bacterial cell wall permeability. |
|
| DC49457 |
Sulfaguanidine-d4 |
Sulfaguanidine-d4 is the deuterium labeled Sulfaguanidine. Sulfaguanidine, belongs to the class of sulfonamide drug, is an orally active antibiotic. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery. |
|
| DC49458 |
Amp1EP9 |
Amp1EP9 is an antimicrobial peptide. Amp1EP9 is a powerful tool for developing potent and nontoxic antimicrobial drugs. Amp1EP9 has the potential for the research of multidrug-resistant bacterial infections. |
|
| DC49459 |
Antibacterial agent 78 |
Antibacterial agent 78 (compound 30) is an antibacterial agent. |
|
| DC49460 |
Ph-Ph+ |
Ph-Ph+ is a hemiprotonic compound, which is produced from phenanthroline (ph) dimerization. Ph-Ph+ has antitumor, antibacterial and antifungal activities. |
|
| DC49461 |
DMA-135 hydrochloride |
DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies. |
|
