| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC41151 | Boc-Dap-NE Featured | Boc-Dap-NE, a dipeptide, is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC39818 | CL2-SN-38(DCA) Featured | CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 (Item No. 15632) and a maleimidocaproyl linker.1 CL2-SN-38 has been linked to tumor-selective human monoclonal antibodies, such as anti-CEACAM5 (hMN-14) to target SN-38 to tumor sites and improve its solubility. CL2-SN-38 linked to hMN-14 binds (Kd = 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC50 = 5.3 nM). CL2-SN-38 linked to hMN-14 increases survival in a colon carcinoma mouse model of lung metastasis. |
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| DC39235 | Fmoc-Val-Ala-PAB-OH Featured | Fmoc-Val-Ala-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| A124 | Trastuzumab emtansine Featured | Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer. |
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| DC42440 | Fmoc-Gly-Gly-Phe-OH Featured | Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC42441 | Fmoc-Gly-Gly-D-Phe-OH | Fmoc-Gly-Gly-D-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Gly-Gly-D-Phe-OH is the D-isomer of Fmoc-Gly-Gly-Phe-OH. |
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| DC42442 | Fmoc-Val-D-Cit-PAB | Fmoc-D-Val-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC). |
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| DC42443 | Fmoc-D-Val-Cit-PAB | Fmoc-D-Val-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC). |
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| DC42444 | Fmoc-D-Val-D-Cit-PAB | Fmoc-D-Val-D-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC). |
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| DC42455 | Acetylene-linker-Val-Cit-PABC-MMAE | Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin (MMAE). Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) is a drug-linker conjugate for ADC. |
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| DC42551 | Fmoc-NH-PEG2-NH2 | Fmoc-NH-PEG2-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC43960 | MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH Featured | MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44523 | 1,6-Bis(mesyloxy)hexane | 16-Bismesyloxyhexane is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44524 | 6-Azido-hexylamine | 6-Azido-hexylamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44525 | Biotin-C4-amide-C5-NH2 | Biotin-C4-amide-C5-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44526 | Biotin-PEG1-NH2 | Biotin-PEG1-NH2 is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44527 | Biotin-PEG1-azide | Biotin-PEG1-azide is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44528 | N-trifluoroacetyl-β-alanyl chloride | N-trifluoroacetyl-β-alanyl chloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44529 | Folate-PEG3-amine | Folate-PEG3-amine is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44530 | BS3 Crosslinker disodium | BS3 Crosslinker disodium is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44531 | (2-Pyridyldithio)-PEG6 acid | 2-Pyridyldithio-PEG6 acid is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44532 | Biotin-sar-oh | Biotin-sar-oh is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44533 | Biotin-PEG4-PFP ester | Biotin-PEG4-PFP ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44707 | DBCO-S-S-acid | DBCO-S-S-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44708 | Biotin-PEG2-methyl ethanethioate | Biotin-PEG2-methyl ethanethioate is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44709 | Azide-C2-Azide | Azide-C2-Azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44710 | Azido-C6-OH | Azido-C6-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44711 | Propargyl-Tos | Propargyl-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC44712 | DBCO-PEG4-GGFG-DX8951 | DBCO-PEG4-GGFG-DX8951 is a drug-linker conjugate for ADC with potent antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the non-cleavable ADC linker DBCO-PEG4-GGFG. |
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| DC44783 | 7-Aminomethyl-10-methyl-11-fluoro camptothecin | 7-Aminomethyl-10-methyl-11-fluoro camptothecin is a cytotoxin of MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin. 7-Aminomethyl-10-methyl-11-fluoro camptothecin can be used for the synthesis of camptothecin antibody-drug conjugate (ADC). |
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