Cat. No. | Product name | CAS No. |
DC5025 |
PFI-1 (PF-6405761)
Featured
PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM. |
1403764-72-6 |
DC7649 |
PFI-3
Featured
PFI-3 is a novel potent, selective and cell permeable inhibitor of SMARCA4 and PB1(5) bromodomains with IC50 ~ 89 nM and 48 nM respectively. |
1819363-80-8 |
DC8291 |
PFI-4
Featured
PFI-4 is a potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). |
900305-37-5 |
DC10786 |
PLX51107
Featured
PLX51107 is a novel BET inhibitor with a unique binding mode in the acetylated lysine binding pocket of BRD4 that differentiates it from other compounds under investigation. |
1627929-55-8 |
DC12248 |
PROTAC BET degrader-2
PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression. |
2093388-33-9 |
DC11041 |
QCA276
QCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM, QCA276 is the BET ligand for PROTAC QCA570. |
2126819-40-5 |
DC8320 |
RVX-208
Featured
RVX-208(RVX 000222) is a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo; is a BET bromodomain antagonist. |
1044870-39-4 |
DC8261 |
(-)-JQ-1
Featured
The (-)-JQ1 stereoisomer has no appreciable affinity to BET bromodomains,it is the negative control of +JQ-1. |
1268524-71-5 |
DC10190 |
TPOP146
TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4. |
2018300-62-2 |
DC10066 |
XD14
Featured
XD14 is a BET bromodomain inhibitor with Kd values of 160, 170, 380, 490, 830 and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2) respectively. |
1370888-71-3 |
DC11261 |
ZL0420
Featured
ZL0420 is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively. |
2229039-45-4 |
DC31037 |
IBET151-Az
IBET151-Az is a IBET151 derivative for PROTAC synthesis.. |
|
DC31039 |
JQ1-Az
JQ1-Az is a JQ1 derivative.. |
|
DC31040 |
FT-1101
FT-1101 is a potent pan-BET bromodomain inhibitor that displays equipotent inhibition for BRD2, BRD3, BRD4, and BRDT with Kd < 20 nM. |
|
DC31043 |
PF-CBP1 hydrochloride
A potent, highly selective inhibitor of the CBP and p300 bromodomains with IC50 of 125 nM and 363 nM, respectively. |
|
DC31053 |
GSK525768A
GSK525768A is an enantiomer, negative control compound of I-BET762 (GSK525762A), shows no activity against BET family proteins BRD2, BRD3 and BRD4.. |
1260530-25-3 |
DC31058 |
GSK4027
GSK4027 (GSK 4027, GSK-4027) is a potent, selective, cell-penetrant chemical probe of PCAF/GCN5 bromodomain with pKi of 8.9 for both. |
2079896-25-4 |
DC31060 |
GSK-340
GSK-340 is a potent, selective inhibitor of second bromodomains of the BET family (BD2) with pKd of 8.18, 7.49, 7.72 and 7.68 for BRD4 BD2, BRD3 BD2, BRD2 BD2 and BRD4T BD2, respectively. |
2222509-79-5 |
DC70136 |
TAF1 bromodomain inhibitor
A potent and selective TAF1(2) bromodomain inhibitor. |
|
DC70270 |
BRD4 D1 inhibitor 30
BRD4 D1 inhibitor 30 is a high-affinity, BRD4 D1-selective chemical probe with Kd of 18 nM, 500-fold selectivity against BRD2 D1 and BRD4 D2.BRD4 D1 inhibitor 30 down regulated inflammation, IL-8 and chemokine in cell based assays, but was unable to reduce c-Myc expression at low concentration in multiple myeloma cells. |
|
DC70271 |
BRD8 inhibitor DN02
BRD8 inhibitor DN02 is a first-in-class selective and cellularly active probe for NuA4 factor BRD8 (BD1) with IC50 of 34 nM, no affinity for BRD8 {BD2}, CBP, and p300. |
|
DC70279 |
BY27
BY27 (BD2 inhibitor BY27) is a potent, highly selective BET BD2 inhibitor with Ki of 8.9/8.2/14.2 nM for BRD2/3/4-BD2 respectively.BY27 displays 38-fold selectivity for BRD2-BD2 over BRD2-BD1.BY27 showed good antitumor activity in the MV4-11 xenograft model with an improved in vivo tolerance in mice compared with I-BET762. |
2247236-59-3 |