Cat. No. | Product name | CAS No. |
DC10609 |
BMS-986158
Featured
BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins. |
1800340-40-2 |
DC9923 |
CeMMEC1
Featured
CeMMEC1 is a novel potent inhibitor of the second bromodomain of TAF1, binding neither the first nor the second bromodomain of BRD4. |
440662-09-9 |
DC5046 |
CPI203 (CPI-203)
Featured
CPI203 is a novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~37 nM (BRD4 α-screen assay). |
1446144-04-2 |
DC8619 |
CPI-268456
Featured
CPI-268456 is a potential BET bromodomain inhibitor. |
1380087-86-4 |
DC10477 |
CPI-637
Featured
CPI-637 is a potent and selective CBP/EP300 bromodomains inhibitor with IC50 of 0.03±0.01μM and 11.0±0.6 μM for CBP/EP300 and BRD4, respectively. |
1884712-47-3 |
DC10845 |
FL-411
Featured
FL-411 is a selective BRD4 inhibitor. |
2118944-88-8 |
DC9934 |
GNE-272
GNE-272 is a in Vivo Probe for the Bromodomains of CBP/EP300. |
1936428-93-1 |
DC12313 |
GNE-371
GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2). |
1926986-36-8 |
DC11729 |
GNE-781
Featured
GNE-781 is a potent, selective, non-CNS penetrant, orally active CBP/p300 bromodomain inhibitor with IC50 of 0.94/1.2 nM in TR-FRET assays. |
1936422-33-1 |
DC5147 |
Molibresib (I-BET-762)
Featured
GSK 525762A is a potent small molecule inhibitors that disrupt the function of the BET family of bromodomains (Brd2, Brd3, and Brd4). |
1260907-17-2 |
DC8360 |
GSK 5959
Featured
GSK 5959 is a potent, cell-permeable inhibitor of the BRPF1 bromodomain (IC50 = 80 nM). |
901245-65-6 |
DC8766 |
GSK1324726A (I-BET726)
Featured
GSK1324726A (I-BET726) is a novel, potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC50= 41 nM), BRD3 (IC50= 31 nM), and BRD4 (IC50= 22 nM). |
1300031-52-0 |
DC9831 |
GSK6853
Featured
GSK6853 is a potent, soluble, cell active, and highly selective inhibitor of the BRPF1 bromodomain |
1910124-24-1 |
DC5183 |
I-BET151
Featured
I-BET151 (GSK1210151A) is a novel selective BET inhibitor for BRD2, BRD3 and BRD4 with IC50 of 0.5 μM, 0.25 μM, and 0.79 μM, respectively. |
1300031-49-5 |
DC9658 |
I-BRD9
Featured
I-BRD9 is a potent and selective BRD9 inhibitor (pIC50 = 7.3). Exhibits >70-fold selectivity for BRD9 over a panel of 34 other bromodomains and >700-fold selectivity over the BET family. |
1714146-59-4 |
DC9836 |
Mivebresib(ABBV-075)
Featured
Mivebresib is a novel BET family inhibitor, disrupts critical transcription programs that drive prostate cancer growth to induce potent anti-tumor activity in vitro and in vivo. |
1445993-26-9 |
DC7682 |
MS417
Featured
MS417 is a novel BrD inhibitor with high affinity and specificity For the BrDs of BET proteins. pIC50 7.52 (IC50 30 nM). |
916489-36-6 |
DC11063 |
MS645
MS645 (MS-645) is a novel, bivalent bromodomain (BRD) inhibitor with Ki of 18.4 nM for tandem BD1-BD2 (BRD4 BD1/BD2 ), shows12- to 28-fold gain in affinity for binding to the tandem BD1-BD2 over the single BD1 or BD2. |
|
DC10023 |
MT-1
Featured
MT1 is a bivalent chemical probe of BET bromodomains.MT1 is an intramolecular bivalent BRD4 binder that is more than 100-fold more potent, in cellular assays, than the corresponding monovalent antagonist, JQ1. |
|
DC9758 |
NI-57
Featured
NI-57 is a potent inhibitor of the bromodomains of BRPF proteins that binds to BRPF1B, BRPF2, and BRPF3 with Kd values of 31, 108, and 408 nM, respectively, as determined by isothermal titration calorimetry. |
1883548-89-7 |
DC7850 |
OF-1
Featured
OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain with Kd of 100 nM and 500 nM, respectively. |
919973-83-4 |
DC9305 |
PF-CBP1(PF-06670910) hydrochloride
Featured
PF-CBP1 is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates targets of CBP in macrophages primary neurons. |
1962928-21-7 |