Cat. No. | Product name | CAS No. |
DC9679 |
BAY1217389
Featured
BAY1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity. |
1554458-53-5 |
DC10526 |
BAY-1895344 HCl(Elimusertib)
Featured
BAY-1895344 is a potent and selective ATM inhibitor. BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride. |
1876467-74-1 |
DC11915 |
BAY-958
BAY-958 (BAY958, LDC526) is a potent, selective PTEFb/CDK9 inhibitor with IC50 of 5 nM against CDK9/CyclinT1. |
1335490-39-5 |
DC10860 |
BDP5290
Featured
BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively. |
1817698-21-7 |
DC11470 |
Belotecan hydrochloride(CKD-602)
Featured
Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic and water-soluble camptothecin derivative. |
213819-48-8 |
DC7905 |
beta-Lapachone (ARQ-501, CO-501)
Featured
Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2. |
4707-32-8 |
DC9832 |
Betulinic acid
Featured
Betulinic acid, a pentacyclic triterpene, selectively induces apoptosis in tumor cells, also is a inhibitor of HIV-1 with EC50 of 1.4 μ M. |
472-15-1 |
DC8571 |
BGP-15
Featured
BGP-15 is a PARP inhibitor and insulin sensitizer. |
66611-37-8 |
DC7083 |
Bi 2536
Featured
BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM, BI2536 shows 4- and 11-fold greater selectivity against Plk2 and Plk3; BI2536 also is a BRD4 inhibitor(IC50= 25 nM). |
755038-02-9 |
DC7085 |
BIBR-1532
Featured
BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM. |
321674-73-1 |
DC10434 |
Bisantrene
Featured
Bisantrene is a highly effective antitumor drug, targets eukaryotic type II topoisomerases. |
78186-34-2 |
DC4196 |
Bleomycin Sulfate
Featured
Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells. |
9041-93-4 |
DC7959 |
BMH-21
Featured
BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I transcription; does not cause phosphorylation of H2AX. |
896705-16-1 |
DC8453 |
Talazoparib(BMN-673)tosylate
Featured
Talazoparib, also known as BMN-673 and MDV-3800, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity (PARP1 IC50 = 0.57 nmol/L). Talazoparib acts as an inhibitor of poly ADP ribose polymerase(PARP) which aids in single strand DNA repair. Cells that have BRCA1/2 mutations are susceptible to the cytotoxic effects of PARP inhibitors because of an accumulation of DNA damage. Talazoparib is theorized to have a higher potency than olaparib due to the additional mechanism of action called PARP trapping. PARP trapping is the mechanism of action where the PARP molecule is trapped on the DNA, which interferes with the cells ability to replicate. Talazoparib is found to be ~100 fold more efficient in PARP trapping than olaparib. |
1373431-65-2 |
DC2008 |
Talazoparib(BMN-673)
Featured
BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM. |
1207456-01-6 |
DC8452 |
BMN-673 8R,9S
BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673. BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM(PARP1). It does not inhibit PARG and is highly sensitive to PTEN mutation. |
1207456-00-5 |
DC8762 |
BMS-265246
BMS-265246 is a potent and selective CDK1/2 inhibitor for CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 nM and 9 nM, respectively. |
582315-72-8 |
DC8513 |
BMS-3
Featured
BMS-3 is a potent inhibitor of the LIM kinase. It has IC50's of 5nM and 6 nM for LIMK1 and LIMK2 respectively. |
1338247-30-5 |
DC9846 |
BS-181
Featured
BS-181 is a highly selective CDK7 inhibitor with IC50 of 21 nM. ; >40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. |
1092443-52-1 |
DC8101 |
BS-181 hydrochloride
Featured
BS-181 is a highly selective CDK7 inhibitor with IC50 of 21 nM. ; >40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. |
1397219-81-6 |
DC8517 |
BS194
Featured
BS-194 is a selective and potent CDK inhibitor, which inhibits CDK2, CDK1, CDK5, CDK7, and CDK9 with IC50 values of 3, 30, 30, 250, and 90 nM respectively. |
1092443-55-4 |
DC7378 |
BSI-201
BSI-201 (Iniparib; NSC-746045) is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC). |
160003-66-7 |