Cat. No. | Product name | CAS No. |
DC7231 |
PHA-848125(Milciclib)
Featured
PHA-848125(Milciclib) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM; >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7. |
802539-81-7 |
DC8075 |
Purvalanol A(NG 60)
Featured
Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. |
212844-53-6 |
DC7256 |
Purvalanol B(NG-95)
Featured
Purvalanol B(NG-95) is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. |
212844-54-7 |
DC2068 |
R547
R547 is a potent and selective CDK inhibitor with Ki and IC50 of 1-3 nM and 80 nM respectively. |
741713-40-6 |
DC7768 |
RGB286638
Featured
RGB-286638 is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6. |
784210-88-4 |
DC3116 |
RO-3306
Featured
Ro-3306 is a potent and selective inhibitor of CDK1 with Ki value of 35 nM for CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D. |
872573-93-8 |
DC12353 |
Roniciclib (BAY 1000394)
Roniciclib is an orally bioavailable pan-cyclin dependent kinase (CDK) inhibitor, with IC50s of 5-25 nM for CDK1, CDK2, CDK3, CDK4, CDK7 and CDK9. |
1223498-69-8 |
DC4124 |
ROSCOVITINE(Seliciclib)
Featured
Roscovitine (Seliciclib, CYC202, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p53 with IC50 of 0.65 μM, 0.7 μM, 0.7 μM and 0.16 μM, respectively. |
186692-46-6 |
DC8737 |
SCH900776 S-isomer
Featured
SCH900776 (S-isomer) is the S-isomer form of SCH900776, which is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50 = 3 nM), highly selective against Chk2 (IC50 = 1500 nM) and cyclin-dependent kinase CDK2 (IC50 |
891494-64-7 |
DC10628 |
Senexin A
Senexin A is a potent and selective inhibitor of CDK8 and its nearest relative, CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19 ATP site binding, respectively. |
1366002-50-7 |
DC7297 |
SNS-032(BMS-387032)
Featured
SNS-032(BMS-387032) is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). |
345627-80-7 |
DC7928 |
SU9516
Featured
SU-9516 is a selective CDK2 inhibtor with IC50 of 22 nM; less potent for CDK1/CDK4(IC50=40/200 nM), no inhibition on PKC, EGFR, p38MAPK etc. |
377090-84-1 |
DC7653 |
THZ1 free base
Featured
THZ1 is a novel selective and potent covalent CDK7 inhibitor with IC50(binding affinity) of 3.2 nM; inhibits Jurkat cell's proliferation with IC50 of 50 nM. |
1604810-83-4 |
DC10042 |
THZ1 Hydrochloride
Featured
THZ1 is a novel selective and potent covalent CDK7 inhibitor with IC50(binding affinity) of 3.2 nM; inhibits Jurkat cell's proliferation with IC50 of 50 nM. |
1604810-83-4 |
DC10827 |
THZ531
Featured
THZ531 is a covalent CDK12 and CDK13 covalent inhibitor. |
1702809-17-3 |
DC10750 |
Voruciclib
Featured
Voruciclib is a protein kinase inhibitor specific for the cyclin-dependent kinase 4 (CDK4) with potential antineoplastic activity. |
1000023-04-0 |
DC8068 |
WHI-P180(Janex 3)
Featured
WHI-P180(Janex 3) is a potent inhibitor of IgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (CDK2; IC50 = 1µM) by blocking the ATP site |
211555-08-7 |
DC11254 | iCDK9 | 1263369-28-3 |
DC11253 | Amt-87 | 1609019-52-4 |
DC11282 |
THZ2
Featured
THZ2 is a potent and selective CDK7 inhibitor with IC50 of 13.9 nM. |
1604810-84-5 |
DC7493 |
SB1317(TG-02)
Featured
SB1317(TG-02) is a novel small molecule potent CDK2/JAK2/FLT3 inhibitor with IC50s of 13/73/56 nM respectively. |
937270-47-8 |
DC27001 |
SR-4835
Featured
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13. |
2387704-62-1 |