Cat. No. | Product name | CAS No. |
DC7158 |
IKK-16 HCl
Featured
IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
1186195-62-9 |
DC9485 |
IKK-16(free base)
Featured
IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
873225-46-8 |
DC9484 |
IKK-2 inhibitor VIII
Featured
IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM. |
406209-26-5 |
DC7802 |
IKK(epsilon)-IN-1 (IKKE-IN-1)
Featured
IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. |
1292310-49-6 |
DC10205 |
Ilaprazole
Featured
Ilaprazole (IY-81149) is a proton pump inhibitor; inhibits H+/K+-ATPase with an IC50 of 6.0 μM. |
172152-36-2 |
DC12631 |
IM176OUT05
Featured
IM176OUT05 is a novel, and safe small molecule that improves the acquisition and maintenance of stem cell pluripotency, inhibits electron transport chain (ETC) in the A549 lung carcinoma cell line with IC50 of 3.2 uM. |
1544871-16-0 |
DC9242 |
Imatinib(free base)
Featured
Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. Imatinib is used to treat chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. |
152459-95-5 |
DC4181 |
Imatinib mesylate
Featured
Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. |
220127-57-1 |
DC8770 |
IMD-0354
Featured
IMD-0354 is a synthetic selective NF-kB inhibitor. |
978-62-1 |
DC8890 |
Imidafenacin
Featured
Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). |
170105-16-5 |
DC22092 |
Imidazole ketone erastin(IKE)
Featured
Imidazole ketone erastin (IKE, Ferroptosis inducer IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications. |
1801530-11-9 |
DC8988 |
Imiquimod
Featured
Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas. |
99011-02-6 |
DC10027 |
Importazole
Featured
Importazole is an inhibitor of importin-β transport receptors. |
662163-81-7 |
DC9756 |
IMR-1
Featured
IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. |
310456-65-6 |
DC9785 |
IMR-1A
Featured
IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L. |
331862-41-0 |
DC12578 |
IMTPPE
Featured
IMTPPE (SID3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells. |
851688-13-6 |
DC10730 |
Inarigivir(ORI-9020,SB-9000)
Featured
Inarigivir(SB-9000) is a novel dinucleotide, evaluated in transgenic mice expressing hepatitis B virus (HBV), significantly reduced liver HBV DNA。 |
475650-36-3 |
DC7015 |
INCB024360 analogue(IDO-IN-1)
Featured
INCB024360 is a potent IDO1 inhibitor(IC50=10 nM) with desirable pharmaceutical properties, which is poised to start clinical trials in cancer patients. |
914471-09-3 |
DC20176 |
INCB057643
Featured
INCB057643 is a BET inhibitor that binds to the acetylated lysine recognition motifs found in the BRD of BET proteins, thereby preventing the interaction between the BET proteins and acetylated lysines on histones. |
1820889-23-3 |
DC26025 |
INCB086550(INCB-086550)
Featured
INCB086550 is an orally available, small molecule inhibitor of PD-L1 with potential immune checkpoint inhibitory and antineoplastic activities. In vitro, INCB086550 selectively and potently blocked the PD-L1/PD-1 interaction, induced PD-L1 dimerization and internalization, and induced stimulation-dependent cytokine production in primary human immune cells. In vivo, INCB086550 reduced tumor growth in CD34+ humanized mice and induced T-cell activation gene signatures, consistent with PD-L1/PD-1 pathway blockade. Preliminary data from an ongoing phase I study confirmed PD-L1/PD-1 blockade in peripheral blood cells, with increased immune activation and tumor growth control. |
2230911-59-6 |
DC7167 |
Capmatinib(INCB28060)
Featured
INCB28060 is a novel orally active inhibitor (IC50=0.13 nM) of c-MET kinase. |
1029712-80-8 |
DC7429 |
INCB 8761
Featured
INCB8761(PF-4136309) is a potent, Selective, and orally bioavailable CCR2 antagonist. |
1341224-83-6 |
DC8906 |
Indinavir
Featured
Indinavir(MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability. |
150378-17-9 |
DC4137 |
Indiplon
Featured
Indiplon is a novel sedative-hypnotic recently approved for the treatment of insomnia. |
325715-02-4 |
DC8838 |
Indirubin
Featured
Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM. |
479-41-4 |
DC20984 |
Indisulam
Featured
Indisulam (E7070) is potent, sulfonamide, cell-cycle inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines. |
165668-41-7 |
DCAPI1311 |
Indole-3-carbinol
Featured
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1). |
700-06-1 |
DC20276 |
Indotecan(LMP400)
Featured
Indotecan(LMP400) is a novel selective and potent topoisomerase I inhibitor with potential anticancer activitity. |
915303-09-2 |
DC10483 |
INF39
Featured
INF39 is an irreversible and noncytotoxic NLRP3 inhibitor. |
866028-26-4 |
DC21138 |
Inflachromene
Featured
Inflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells. |
908568-01-4 |
DC9651 |
Ingenol 3-angelate
Featured
Ingenol 3-Angelate is a PKC(protein kinase C)activator; anti-cancer drug and an active ingredient in Euphorbia peplus. |
75567-37-2 |
DC9646 |
Ingenol
Featured
Ingenol is an extremely weak protein kinase C (PKC) activator. |
30220-46-3 |
DC22212 |
RNF5 INHIBITOR INH-02
Featured
inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1. |
324579-65-9 |
DC7641 |
INH6
Featured
INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment. |
1001753-24-7 |
DC7487 |
Pyroxamide
Featured
Inhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells. |
382180-17-8 |
DC7479 |
Tiplaxtinin(PAI-039)
Featured
Inhibitor of plasminogen activator inhibitor-1 (PAI-1) |
393105-53-8 |
DC7197 |
ML 161
Featured
Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation. |
423735-93-7 |
DC7171 |
INK-128(Sapanisertib)
Featured
INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM; >200-fold less potent to class I PI3K isoforms. |
1224844-38-5 |
DC10555 |
inS3-54A18
Featured
inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties. |
328998-53-4 |
DC7430 |
Obeticholic acid (INT-747)
Featured
INT-747(Obeticholic acid; 6-ECDCA) is a potent and selective FXR agonist(EC50=99 nM) endowed with anticholestatic activity. |
459789-99-2 |
DC8328 |
IRAK-1/4 Inhibitor
Featured
Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor is a benzimidazole compound that acts as a cell-permeable, potent selective inhibitor of IL-1 kinases. |
509093-47-4 |
DC8124 |
ETH 2120(Sodium ionophore III)
Featured
Ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc. with a solvent polymeric membrane electrode. |
81686-22-8 |
DC5070 |
IOX2
Featured
IOX 2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). IOX 2 displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases. |
931398-72-0 |
DC7614 |
IOX1
Featured
IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. |
5852-78-8 |
DC10825 |
IOX4
Featured
IOX4 is a potent inhibitor of PHD2 (IC50 = 1.6 nM). |
1154097-71-8 |
DC21756 |
IP6K1 inhibitor TNP
Featured
IP6K1 inhibitor TNP is a potent, selective inositol hexakisphosphate kinase IP6K with IC50 of 0.47 uM (IP6K1), does not inhibit either human or yeast Vip/PPIP5K. |
519178-28-0 |
DC5072 |
Duvelisib (IPI-145, INK1197)
Featured
IPI-145 is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. |
1201438-56-3 |
DC9829 |
IPI-549
Featured
IPI-549 is an orally administered immuno-oncology development candidate that selectively inhibits PI3K-gamma. |
1693758-51-8 |
DCAPI1573 |
Ipragliflozin (ASP1941)
Featured
Ipragliflozin (ASP1941) is a Novel Selective Sodium-Dependent Glucose Co-Transporter 2 Inhibitor, on Urinary Glucose Excretion in Healthy Subjects |
761423-87-4 |
DC10295 |
IPSU
Featured
IPSU is a selective, orally available and brain penetrant OX2R antagonist with a pKi of 7.85. |
1373765-19-5 |
DC9952 |
IQ-1
Featured
IQ-1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on. |
331001-62-8 |
DC9694 |
IQ-1S
Featured
IQ-1S is a selective JNK3 inhibitor (IC50 values are 390, 360 and 87 nM for JNK1, 2 and 3 respectively). |
23146-22-7 |
DC9491 |
IRAK inhibitor 1
Featured
IRAK inhibitor 1 is an interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor. |
1042224-63-4 |
DC10584 |
IRAK4-IN-1
Featured
IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM. |
1820787-94-7 |
DC7173 |
Irbesartan
Featured
Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM. |
138402-11-6 |
DC8771 |
Tucatinib (Irbinitinib,ARRY-380)
Featured
Irbinitinib(ARRY-380; ONT-380) is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR. |
937263-43-9 |
DC23051 |
Irigenin
Featured
Irigenin, an α-glucosidase inhibitor, which has anti-inflammatory, anti-cancer, and anti-metastatic effects. Irigenin can inhibit the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins and mRNAs without an appreciable |
548-76-5 |
DC4180 |
Irinotecan Hydrochloride
Featured
Irinotecan hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. |
100286-90-6 |
DC8934 |
Irinotecan
Featured
Irinotecan(CPT-11) prevents DNA from unwinding by inhibition of topoisomerase 1. |
97682-44-5 |
DC10866 |
Irosustat(STX64)
Featured
Irosustat(STX64) is a potent steroid sulfatase inhibitor, with an IC50 of 8 nM, and exhibits anti-breast cancer activity. |
288628-05-7 |
DC10082 |
ISCK03
Featured
ISCK03 is a cell-permeable inhibitor of SCF-mediated c-kit activation, completely blocking phosphorylation of c-kit in human melanoma cells at a concentration between 1 and 5 µM. |
945526-43-2 |
DC23058 |
Corylifolinin(Isobavachalcone)
Featured
Isobavachalcone is a natural chalcone first isolated from P. corylifolia that displays antibacterial, antifungal, anticancer, anti-reverse transcriptase, antitubercular, and antioxidant activities in various research models. |
20784-50-3 |
DC23110 |
Isoliquiritin
Featured
Isoliquiritin has significant antidepressant-like, antifungal and anti-cancer activities. It induces apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells and inhibit the p53-dependent pathway and showed crosst |
5041-81-6 |
DC22328 |
Isomaltose
Featured
Isomaltose is a glucose disaccharide with an α-(1→6) linkage, as opposed to the α-(1→4) linkage found in maltose. |
499-40-1 |
DCAPI1242 |
Isoniazid(Tubizid)
Featured
Isoniazid is an antibacterial agent used primarily as a tuberculostatic.Target: AntibacterialIsoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG [1]. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824 [2, 3]. Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing [4]. |
54-85-3 |
DC23107 |
ISOQUERCITRIN
Featured
Isoquercitrin is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation; it is also a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. |
482-35-9 |
DC23018 |
Isoscopoletin
Featured
Isoscopoletin possesses inhibitory activity against hepatitis B virus (HBV) replication; it also shows substantial inhibition against multi-drug resistant CEM/ADR5000 cells and human CCRF-CEM leukaemia cells, with the IC50 value is 1.6 and 4.0 microM, res |
776-86-3 |
DC23053 |
Isosilybin
Featured
Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities.It inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM) and reduces ADP/Fe3+-induced malondialdehyde (MDA) production and lac |
72581-71-6 |
DC9824 |
Isosteviol
Featured
Isosteviol is a derivative of stevioside, a constituent of Stevia rebaudiana, which is commonly used as a noncaloric sugar substitute in Japan and Brazil. |
27975-19-5 |
DC23095 |
ISOVITEXIN
Featured
Isovitexin, a food phytochemical contained in dietary rice products, it exhibits in vivo α-glucosidase inhibition, it possesses antihyperglycemic, neuroprotective, anti-inflammatory and anti-oxidant activities. Isovitexin inhibited xanthine oxidase with a |
38953-85-4 |
DC5107 |
SB-715992 (Ispinesib)
Featured
Ispinesib (SB 715992) is a potent mitotic kinesin KSP (Eg5) inhibitor with a Ki and an IC50 of 0.6 and 4.1 nM, respectively. |
336113-53-2 |
DC8772 |
Isradipine
Featured
Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM. |
75695-93-1 |
DC7431 |
ISRIB
Featured
ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM. |
1597403-47-8 |
DC22333 |
iST2-2
Featured
iST2-2 is a novel ST2 (suppression of tumorigenicity 2) inhibitor active in vivo. |
|
DCAPI1080 |
Istradefylline (KW-6002)
Featured
Istradefylline(KW6002) is a very potent, selective and orally active adenosine A2A receptor antagonist(Ki=2.2 nM) in experimental models of Parkinson's disease. |
155270-99-8 |
DC8304 |
Isoxazole 9(ISX9)
Featured
ISX-9 is a small molecule inducer of adult neural stem cell differentiation both in vitro and in vivo. |
832115-62-5 |
DC10898 |
Protein kinase inhibitor 1
Featured
It is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM. |
1365986-44-2 |
DC10768 |
IT 901
Featured
IT 901 is a c-Rel inhibitor (IC50 = 3 μM). Inhibits IL-2 expression in activated T-cells in vitro. |
1584121-99-2 |
DC10283 |
IT1t dihydrochloride
Featured
IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. |
1092776-63-0 |
DC12378 |
Itacitinib(INCB039110)
Featured
Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis. |
1334298-90-6 |
DC8028 |
ITD-1
Featured
ITD-1 is a novel and highly selective TGFβ pathway inhibitor. ITD-1 molecule turns stem cells into heart cells. |
1099644-42-4 |
DC23662 |
ITI214 free base
Featured
ITI-214 is a potent, selective phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms. |
1160521-50-5 |
DC10220 |
ITSA-1 (ITSA1)
Featured
ITSA-1 (ITSA1) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors. |
200626-61-5 |
DC21157 |
ITX-5061 hydrochloride
Featured
ITX-5061 is a scavenger receptor B1 antagonist that promotes high-density lipoprotein (HDL) levels. |
1252679-52-9 |
DC26005 |
IU1
Featured
IU1 is a selective USP14 inhibitor. IU1 prevents ventilator-induced lung injury in rats. |
314245-33-5 |
DC23797 |
IU1-47
Featured
IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14; accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome; stimulates autophagic flux in primary neurons. |
670270-31-2 |
DC3153 |
Ivabradine hydrochloride
Featured
Ivabradine, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. |
148849-67-6 |
DC4128 |
Ivacaftor (VX-770)
Featured
Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
873054-44-5 |
DC7434 |
IWP-L6
Featured
IWP L6 is a Porcn inhibitor with EC50 of 0.5 nM. |
1427782-89-5 |
DC5028 |
IWP-2
Featured
IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. |
686770-61-6 |
DC5059 |
IWP-3
Featured
IWP-3 is a selective small molecule wnt inhibitor, prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity1. |
687561-60-0 |
DC7053 |
IWR-1
Featured
IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. |
1127442-82-3 |
DCAPI1510 |
Ixabepilone
Featured
Ixabepilone (Azaepothilone B; BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors. |
219989-84-1 |
DC7435 |
J-147
Featured
J-147 is a potent neuroprotective and neurotrophic compound. |
1146963-51-0 |
DC20641 |
J8-C8
Featured
J8-C8 is a small-molecule inhibitor of bacterial N-acyl-homoserine lactone synthase (acyl-HSLs) TofI with IC50 of 35 uM for toxoflavin production. |
1150565-77-7 |
DC11136 |
JAK2 inhibitor G5-7
Featured
JAK2 inhibitor G5-7 is a small molecule, allosteric JAK2 inhibitor that selectively inhibits JAK2-mediated phosphorylation and activation of EGFR and STAT3 by binding to JAK2. |
939681-36-4 |
DC8077 |
WHI-P131(Janex 1)
Featured
Janex 1 selectively inhibits the tyrosine kinase activity of JAK3 with an IC50 value of 78 µM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases (IC50 ≥350 µM). |
202475-60-3 |
DC10095 |
JD5037
Featured
JD5037 is an inverse agonist of peripheral cannabinoid 1 (CB1) receptors (Ki = 0.35 nM). |
1392116-14-1 |
DC9621 |
Jervine
Featured
Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo. |
469-59-0 |
DC8379 |
JH-II-127
Featured
JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor. |
1700693-08-8 |
DC22122 |
JI051
Featured
JI051(JI-051) is a specific compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression. |
2234281-75-3 |
DC10123 |
JI-101
Featured
JI-101 is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor β (PDGFR-β), and ephrin type-B receptor 4 (EphB4). |
900573-88-8 |
DC7437 |
JIB-04
Featured
JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. |
199596-05-9 |
DC9929 |
JK-184
Featured
JK-184 is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). |
315703-52-7 |
DC10595 |
JK-P3
Featured
JK-P3 is a VEGFR-2 inhibitor. |
942655-44-9 |
DC10971 |
JMS-17-2
Featured
JMS-17-2 is a potent and selective antagonist of CX3CR1 with IC50 of 0.32 nM, displays significant selectivity for CX3CR1 over other chemokine receptors such CXCR2, CXCR1, and CXCR4 (IC50>1 uM). |
1380392-05-1 |
DC21167 |
JMV 2959
Featured
JMV 2959 (AEZS-123) is a potent ghrelin receptor (GHS-R1A) antaognist with binding IC50 of 32 nM. |
925238-89-7 |
DC12804 |
JND3229
Featured
JND3229 is a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy (IC50 = 5.8 nM). |
2260886-64-2 |
DC7843 |
JNJ 42153605
Featured
JNJ 42153605 is a positive allosteric modulator of the metabotropic glutamate 2 receptor. |
1254977-87-1 |
DC11404 |
JNJ0966
Featured
JNJ0966 is a highly selective compound that inhibited activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. |
315705-75-0 |
DC12374 |
JNJ-10229570
Featured
JNJ-10229570 (JNJ10229570) is a novel potent, selective melanocortin receptor MC1R and MC5R antagonist with binding IC50 of 270 nM and 200 nM, respectively. |
524923-88-4 |
DC22665 |
JNJ18038683
Featured
JNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays. |
851376-05-1 |
DC7175 |
JNJ-26854165 (Serdemetan)
Featured
JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. |
881202-45-5 |
DC23567 |
JNJ303
Featured
JNJ303 is a potent, specific delayed rectifier potassium current I(Ks) blocker with IC50 of 64 nM, shows no effects on other cardiac channels (IC50=3.3, >10, 11.1 and 12.6 uM for Na, ICa, Ito and IKr currents). |
878489-28-2 |
DC8140 |
JNJ31020028
Featured
JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors. |
1094873-14-9 |
DC7177 |
JNJ 38877605
Featured
JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. |
943540-75-8 |
DC8617 |
JNJ-42041935
Featured
JNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. |
1193383-09-3 |
DC9662 |
JNJ-42165279
Featured
JNJ-42165279 is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 70nM. |
1346528-50-4 |
DC22125 |
JNJ4796
Featured
JNJ4796 (JNJ 4796, JNJ-4796) is an orally active small-molecule fusion inhibitor of influenza virus hemagglutinin (HA) with EC50 of 33 nM (H1N1 neutralization). |
2241664-16-2 |
DC21180 |
JNJ-47965567
Featured
JNJ-47965567 is a potent, selective, centrally permeable P2X7 receptor antagonist with pKi of 7.9 and 8.7 for human and rat P2X7, respectively. |
1428327-31-4 |
DC12166 |
JNJ-5207852
Featured
JNJ-5207852 is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively. |
398473-34-2 |
DC21182 |
JNJ-53718678
Featured
JNJ-53718678 (JNJ53718678, JNJ-678) is a potent (Kd=7.4 nM), small-molecule inhibitor of the F-glycoprotein-mediated complex membrane fusion process of the RSV. |
1383450-81-4 |
DC12271 |
JNJ-54175446
Featured
JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively. |
1627902-21-9 |
DC10882 |
JNJ-632
Featured
JNJ-632 is a novel and potent inhibitor of HBV replication in vitro across genotypes A-D. |
1572510-42-9 |
DC9271 |
JNJ-63533054
Featured
JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM. |
1802326-66-4 |
DC7178 |
JNJ-7706621
Featured
JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6; also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1. |
443797-96-4 |
DC8773 |
JNJ-7777120
Featured
JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors. |
459168-41-3 |
DC22516 |
Unii-cedo9qxyzk
Featured
JPH203 (KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2. |
1037592-40-7 |
DC12191 |
JQ-35-(S)
Featured
JQ-35, (S)- is an inhibitor of the Bromodomain and Extra-Terminal (BET) family bromodomain-containing proteins with potential antineoplastic activity. |
1349719-98-7 |
DC11421 |
JQEZ5
Featured
JQEZ5 is a novel and potent EZH2 inhibitor. |
1913252-04-6 |
DC12422 |
JSH-150
Featured
JSH-150 (JSH150) is a potent, highly selective inhibitor of CDK9 kinase with IC50 of 1 nM in the biochemical assays, displays 300-10000-fold selectivity over other CDK kinase family members (CDK7 IC50=1.72 uM). |
2247481-21-4 |
DC7741 |
JSH-23
Featured
JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM. |
749886-87-1 |
DC10607 |
JTE-013
Featured
JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM. |
383150-41-2 |
DC26081 |
JTE-852
Featured
JTE-852 is a novel potent, selective, ATP-competitive Syk kinase inhibitor with IC50 of 1.25/1.28 nM for human/rat Syk, respectively. |
909283-40-5 |
DC7169 |
JW55
Featured
JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW55 decreased auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9 uM and 830 nM respectively. |
664993-53-7 |
DC8352 |
JZL-195
Featured
JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50 = 2 and 4 nM, respectively). |
1210004-12-8 |
DC5143 |
JZL184
Featured
JZL184 is a strong and selective inhibitor of Monoglyceride Lipase |
1101854-58-3 |
DC9272 |
K 858
Featured
K 858 is an ATP-uncompetitive mitotic kinesin Eg5 inhibitor, which does not effect microtubule dynamics. |
72926-24-0 |
DC7742 |
K02288
Featured
K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA. |
1431985-92-0 |
DC9286 |
K03861
Featured
K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely. |
853299-07-7 |
DC7774 |
Ripasudil(K-115)
Featured
K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor; is in Phase II clinical development in patients with POAG or ocular hypertension. |
887375-67-9 |
DC9625 |
K145 (hydrochloride)
Featured
K145 is a selective SphK2 inhibitor with an IC50 of 4.30±0.06 μM , while no inhibition of SphK1 at concentrations up to 10 μM. IC50 value: 4.3 uM. |
1449240-68-9 |
DC21196 |
K-604
Featured
K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2. |
217094-32-1 |
DC23031 |
Astragalin
Featured
Kaempferol-3-glucoside is an orally bioavailable flavonoid that has been isolated from the leaves of D. kaki and R. agrestis and has anti-inflammatory activity. |
480-10-4 |
DC10495 |
KAI407
Featured
KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. |
1513879-18-9 |
DC21199 |
KAR-5585
Featured
KAR-5585 (Rodatristat) is the prodrug of the potent TPH1 inhibitor KAR5417, shows robust reduction of intestinal serotonin (5-HT) levels in mice. |
1673571-51-1 |
DC7669 |
Kartogenin (KGN)
Featured
Kartogenin(KGN) is a small molecule stimulator of chondrogenesis; promotes chondrocyte differentiation(EC50=100 nM) and binds to filamin A. |
4727-31-5 |
DC8084 |
kb NB 142-70
Featured
kb NB 142-70 is a selective protein kinase D (PKD) inhibitor. |
1233533-04-4 |
DC7717 |
kb-NB77-78
Featured
kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor). |
1350622-33-1 |
DC7832 |
KB-R7943 mesylate
Featured
KB-R7943 mesylate is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 mM). |
182004-65-5 |
DC10852 |
KBU2046
Featured
KBU2046, is a small molecule that attaches to tumor proteins involved in metastasis and disables them, so they can’t travel to distant organs. |
1143863-69-7 |
DC8447 |
KC7F2
Featured
KC7F2 is a potent HIF-1 pathway inhibitor and that its potential as a cancer therapy agent warrants further study. |
927822-86-4 |
DC10586 |
KDM4D-IN-1
Featured
KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM. |
2098902-68-0 |
DC23376 |
KDM5-C70
Featured
KDM5-C70 is the cell-permeable derivative of KDM5-C49, potent, selective and cell permeable KDM5 inhibitor with IC50 of 0.3, 0.3 and 0.58 uM for KDM5A, B and C, respectively. |
1596348-32-1 |
DC10285 |
KDM5-IN-1
Featured
KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor with an IC50 of 15.1 nM. |
1628210-26-3 |
DC20226 |
KDOAM25(GTPL8576)
Featured
KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC50 values < 60 nM. |
|
DC10746 |
KDU691
Featured
KDU691 is a PI4K inhibitor. |
1513879-19-0 |
DC11627 |
KEA1-97
Featured
KEA1-97 (KEA 1-97) is a small molecule that disrupts the interaction of thioredoxin with caspase 3. |
2138882-71-8 |
DC5093 |
NSC-664704(Kenpaullone)
Featured
Kenpaullone is an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β). |
142273-20-9 |
DC8326 |
Kevetrin HCl
Featured
Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. |
66592-89-0 |
DC10654 |
KG-501(Naphthol AS-E phosphate)
Featured
KG-501 is a small molecule inhibitor of Aldolase, Histochemical substrate for alkaline phosphatases. |
18228-17-6 |
DC22752 |
KGA-2727
Featured
KGA-2727 is a potent, selective SGLT1 inhibitor with Ki of 97.4 nM, >100-fold selectivity over SGLT2. |
666842-36-0 |
DC20009 |
KH7
Featured
KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. |
330676-02-3 |
DC12275 |
KHS101 hydrochloride
Featured
KHS101 hydrochloride could selectively induce a neuronal differentiation phenotype and interacts with transforming acidic coiled-coil-containing protein 3 (TACC3). |
1784282-12-7 |
DC12043 |
KHS-101
Featured
KHS101 is a selective inducer of neuronal differentiation; induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50 ~1 μM). |
1262770-73-9 |
DC8889 |
Ki16198
Featured
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activity at LPA4, LPA5, LPA6. |
355025-13-7 |
DC7179 |
Ki16425
Featured
Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA4, LPA5, LPA6. |
355025-24-0 |
DC7168 |
Ki20227
Featured
Ki-20227 is a highly selective c-Fms tyrosine kinase(CSF1R) inhibitor with IC50 value of 2 nM; 6 fold and > 100 fold selectivity over VEGFR2(IC50=12 nM) and c-Kit/PDGFR_beta_(IC50=451/217 nM), respectively. |
623142-96-1 |
DC7440 |
KI8751
Featured
Ki8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM, >40-fold selective for VEGFR2 than c-Kit, PDGFRα and FGFR-2, little activity to EGFR, HGFR and InsR. |
228559-41-9 |
DC10518 |
KIN1148
Featured
KIN1148, a small-molecule IRF3 agonist, is a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy. |
1428729-56-9 |
DC10542 |
KIRA6
Featured
KIRA6 is an ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC50 = 0.6 µM) and prevents oligomerization. |
1589527-65-0 |
DC20111 |
Kira8
Featured
Kira8 is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α’s RNase. |
1630086-20-2 |
DC10567 |
KKL-10
Featured
KKL-10 is a small-molecule ribosome rescue inhibitor with broad-spectrum antimicrobial activity against bacteria. |
952849-76-2 |
DC23779 |
KL001(KL-001;KL 001)
Featured
KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock. |
309928-48-1 |
DC11391 |
SEC inhibitor KL-1
Featured
SEC inhibitor KL-1 is a peptidomimetic inhibitor of super elongation complex (SEC) and transcription elongation by Pol II, disrupts cyclin T1-AFF4 interaction (Ki=3.48 uM) within SEC; disrupts the interaction between the SEC scaffolding protein AFF4 and P |
900308-84-1 |
DC11392 |
SEC inhibitor KL-2
Featured
SEC inhibitor KL-2 is a peptidomimetic inhibitor of super elongation complex (SEC) and transcription elongation by Pol II, disrupts cyclin T1-AFF4 interaction (Ki=1.50 uM) within SEC; disrupts the interaction between the SEC scaffolding protein AFF4 and P |
900308-51-2 |
DC9276 |
KM 11060
Featured
KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity. |
774549-97-2 |
DC10536 |
KML-29
Featured
KML29 is an O-hexafluoroisopropyl carbamate analog of JZL 184 that potently and selectively inhibits MAGL (IC50s = 15, 43, and 5.9 nM in mouse, rat, and human brain proteomes, respectively) over FAAH (IC50s >50 μM). |
1380424-42-9 |
DC20257 |
KMN-159
Featured
KMN-159 is a potent prostaglandin E2 type 4 (EP4) receptor agonist with Ki of 0.38 nM and shows five fold increase in potency versus KMN-80. |
|
DC2053 |
KN-62
Featured
KN-62 is a sective, cell-permeable inhibitor of CaM kinase II (IC50 = 0.9 μM). |
127191-97-3 |
DC7441 |
KN-92-hydrochloride
Featured
KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). |
1431698-47-3 |
DC7166 |
KN92 phosphate
Featured
KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). |
1135280-28-2 |
DC7180 |
KN-93 Phosphate
Featured
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). |
1188890-41-6 |
DC8247 |
KNK437
Featured
KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40. |
218924-25-5 |
DC8788 |
Ko 143
Featured
Ko 143 is a potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM), Ko 143 displays > 200-fold selectivity over P-gp and MRP-1 transporters. |
461054-93-3 |
DC10487 |
KO947
Featured
KO-947 is a small molecule inhibitor of extracellular-signal-regulated kinases 1 and 2 (ERK1/2), as a potential treatment for cancers in which the mitogen activated protein kinase (MAPK) pathway. |
1695533-89-1 |
DC7443 |
Kobe0065
Featured
Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD; exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM. |
436133-68-5 |
DC7444 |
kobe2602
Featured
kobe2602 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD; exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55 μM. |
454453-49-7 |
DC20097 |
Kojic acid
Featured
Kojic acid is a natural substance produced by Aspergillus oryzae, also used as an anti-oxidant and radio-protective agent. |
501-30-4 |
DC12108 |
KP-457
Featured
KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and 5050s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MM |
1365803-52-6 |
DC7181 |
KPT-276
Featured
KPT-276, analog of KPT-185, is an orally bioavailable selective inhibitors of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of CRM1. |
1421919-75-6 |
DC7067 |
KPT-330(Selinexor)
Featured
KPT-330, analog of KPT-185, is an orally bioavailable selective CRM1 inhibitor. |
1393477-72-9 |
DC11276 |
KPT-6566
Featured
KPT-6566 is a covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action. |
881487-77-0 |
DC10041 |
KR-33494
Featured
KR-33494 is a fluorescent-tagged and biotin-tagged probe of a potent inhibitor for Fas-mediated cell death (FAF1), KR-33493. |
1021497-97-1 |
DC7793 |
K RAS INHIBITOR-12
Featured
K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C). |
1469337-95-8 |
DC7722 |
K-RAS inhibitor 9
Featured
K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C). |
1469337-91-4 |
DC9906 |
K-Ras-IN-1
Featured
K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure. |
84783-01-7 |
DC8127 |
KRCA-0008
Featured
KRCA-0008 is a potent Ack1 and anaplastic lymphoma kinase (ALK) dual inhibitor (IC50 values are 4 and 12 nM respectively). |
1472795-20-2 |
DC9963 |
Kribb11
Featured
KRIBB11 is a Heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). |
342639-96-7 |
DC10454 |
KRN633
Featured
KRN633 is a potent and selective VEGFR inhibitor. which inhibits tyrosine phosphorylation of VEGFR-2 (IC50 = 1.16 nmol/L) in human umbilical vein endothelial cells. |
286370-15-8 |