Cat. No. | Product name | CAS No. |
DC21033 |
Trilaciclib hydrochloride(G1T28)
Featured
A novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 4 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively. |
1977495-97-8 |
DC22533 |
Eleclazine hydrochloride
Featured
A novel, potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF). |
1448754-43-5 |
DC20439 |
LXRβ agonist 17
Featured
LXRβ agonist 17 is a novel, potent, orally active liver X receptor β (LXRβ) agonist with Ki/EC50 of 3/21 nM, displays 27-fold selectivity over LXRα; also exhibits excellent selectivity against other nuclear hormone receptors (>3,000-fold); induces the expression of LXR target genes in vitro and in vivo. |
1878259-00-7 |
DC21050 |
FN1-8
Featured
FN1-8 is a novel, synthetic small molecule that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity (at 15 uM); inhibits non-canonical Gli activation and acts downstream of the canonical Hh pathway; suppresses cancer cell proliferation in vitro and inhibits tumor growth in vivo. |
1419258-63-1 |
DC10533 |
PKM2 inhibitor(compound 3k)
Featured
A novle PKM2 inhibitor inhibitor. |
94164-88-2 |
DC23940 |
NM107
Featured
NM-107, also known as 2'-C-Methylcytidine; 2'-C-MeC; 2-CMC; mCyd ; 2'CMeC; 2CMC, is a a potent and selective anti-viral drug. NM-107 showed activity to inhibit the replication of foot-and-mouth disease virus. NM-107 exerts potent anti-DENV activity in DENV subgenomic RNA replicon and infectious systems, with an IC50 value of 11.2±0.3μM. NM-107 may be a promising compound for the development of direct-acting antivirals against DENV infection. |
20724-73-6 |
DC39815 |
Tafluprost
Featured
Tafluprost(AFP-168) is an anti-glaucoma prostaglandin (PG) analog.A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma.1,2,3,4 Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency. |
209860-87-7 |
DC22989 |
BMS-204493
Featured
A pan-RAR inverse agonist that blocks RARα activity with IC50 of 114 nM. |
215030-90-3 |
DC23094 |
TRAP-6
Featured
A PAR1 peptide fragment (residues 42-47) that acts as a PAR1 agonist. |
141136-83-6 |
DC22373 |
Dexpramipexole dihydrochloride
Featured
Dexpramipexole 2Hcl(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value:Target: Dopamine ReceptorDexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity. |
104632-27-1 |
DC23934 |
FTI-277
Featured
A peptide mimetic of the C-terminal Cys-Val-Ile-Met of K-Ras4B that potently inhibits FTase (Farnesyltransferase) with IC50 of 0.5 nM. |
170006-73-2 |
DC20311 |
Apraglutide
Featured
A peptidic glucagon like peptide 2 (GLP-2) analogue for treatment of type2 diabetes.. |
1295353-98-8 |
DC22782 |
MDL-72527
Featured
A polyamine oxidase (PAO) inhibitor that inhibits spermine oxidase and N1-acetylpolyamine oxidase with IC50 of 6.1 and 0.02 uM, respectively. |
93565-01-6 |
DC20911 |
Omuralide
Featured
A potent 20S proteasome inhibitor with IC50 of 49 nM (inhibition of proteasomal chymotrypsin-like proteolytic activity).. |
154226-60-5 |
DC22960 |
ICA-105574
Featured
A potent and efficacious hERG channel activator steeply potentiates current amplitudes more than 10-fold with EC50 of 0.5 uM. |
316146-57-3 |
DC21158 |
JAK3-IN-2
Featured
A potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM. |
1443235-95-7 |
DC22627 |
Trametinib DMSO solvate
Featured
A potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM. |
1187431-43-1 |
DC23952 |
GR-79236
Featured
GR79236 is a highly potent and selective adenosine A1 receptor agonist (Ki = 3.1 nM) that has analgesic and anti-inflammatory actions in humans and animals. |
124555-18-6 |
DC22498 |
A-443654
Featured
A potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1. |
552325-16-3 |
DC22584 |
Mavorixafor(AMD-070)
Featured
A potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay. |
558447-26-0 |
DC22583 |
AMD-070 hydrochloride(Mavorixafor)
Featured
A potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay. |
880549-30-4 |
DC22691 |
MK-4618
Featured
A potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM. |
1190389-15-1 |