Cat. No. | Product name | CAS No. |
DC9482 |
17-AAG
Featured
17-AAG(NSC 330507; CP 127374) is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. |
75747-14-7 |
DC11919 |
Arimoclomol
Featured
A nontoxic heat shock protein (HSP) coinducer and potentiator of the heat shock response. |
289893-25-0 |
DC11920 |
Arimoclomol maleate
Featured
A nontoxic, orally active heat shock protein (HSP) coinducer and potentiator of the heat shock response. |
289893-26-1 |
DC12011 |
KU-32
A novel, novobiocin-based, C-terminal inhibitor of Hsp90 and a potent inducer of Hsp70. |
956498-70-7 |
DC11970 |
KU675
Featured
A novel, second-generation C-terminal Hsp90 inhibitor with Kd of 191 and 726 uM for Hsp90α and Hsp90β, respectively. |
1535221-75-0 |
DC11921 |
Bimoclomol
A potent heat shock protein coinducer. |
130493-03-7 |
DC11616 |
KUNG94
A potent, selective Grp94 inhibitor with IC50 of 8 nM. |
2134571-29-0 |
DC11619 |
KUNG29
A potent, selective Grp94 inhibitor with Kd of 0.2 uM. |
1887032-92-9 |
DC11618 |
KUNG38
A potent, selective Grp94 inhibitor with Kd of 0.44 uM. |
1887033-00-2 |
DC11617 |
PU-H54
Featured
PU-H54 is potent, selective Grp94 inhibitor. |
1454619-13-6 |
DC8167 |
Onalespib(AT13387,ATI13387X)
Featured
AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. |
912999-49-6 |
DC5202 |
Luminespib (NVP-AUY922)
Featured
AUY922 (NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 1/2. |
747412-49-3 |
DC7086 |
BIIB021(CNF2024)
Featured
BIIB021(CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. |
848695-25-0 |
DC10498 |
CCT251236
Featured
CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction. |
1693731-40-6 |
DC8477 |
VER-49009
Featured
Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis. |
558640-51-0 |
DC7390 |
CUDC-305(DEBIO 0932)
Featured
Debio 0932 ( CUDC-305 ) is a novel heat shock protein 90 (HSP90) inhibitor trong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L) . |
1061318-81-7 |
DC7320 |
Ganetespib(STA-9090)
Featured
Ganetespib(STA-9090) is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells. |
888216-25-9 |
DC7806 |
Geldanamycin (NSC122750)
Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. |
30562-34-6 |
DC10837 |
HS-10
Featured
HS-10 is a novel Hsp90 inhibitor increases the Tm of Hsp90 by 10.5°C. |
|
DC10831 |
HS-27
Featured
Hs-27 is a Novel Hsp90 Inhibitor, Exhibits Diagnostic and Therapeutic Potential in Triple Negative Breast Cancer. |
1562024-11-6 |
DC10614 |
HSF1A
Featured
HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1). |
1196723-93-9 |
DC10344 |
HSP70-IN-1
Featured
HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM. |
1268273-90-0 |