| DC70662 |
NPX-800
|
NPX-800 is a potent, selective, oral heat shock factor 1 (HSF1) pathway inhibitor. |
| DC8142 |
TAS-116
|
TAS-116 is a highly selective inhibitor of heat shock protein 90α and β, demonstrates potent antitumor activity and minimal ocular toxicity in preclinical models. |
| DC6307 |
XL888
|
XL888 is an orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. |
| DC8299 |
VER155008
|
VER-155008 is a novel, small molecule inhibitor of Hsc70/Hsp70 with GI50 of 5.3-14.4 uM in human breast and colon cancer cell lines. |
| DC9948 |
SNX-5422(PF04929113)
|
PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor (Kd of 41 nM). PF-04929113 also inhibits Her-2 degradation (IC50 of 37 nM). |
| DC4118 |
NVP-BEP800
|
NVP-BEP800 is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM. |
| DC9994 |
ML-346
|
ML346 is a novel activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay. |
| DC9963 |
Kribb11
|
KRIBB11 is a Heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). |
| DC8247 |
KNK437
|
KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40. |
| DC10852 |
KBU2046
|
KBU2046, is a small molecule that attaches to tumor proteins involved in metastasis and disables them, so they can’t travel to distant organs. |
