Cat. No. | Product name | CAS No. |
DC7478 |
Pacritinib
Pacritinib (SB1518) is a potent and selective JAK2 (IC50 = 23 and 19 nM for JAK2WT and JAK2V617F, respectively) and FLT3 (IC(50) = 22 nM) inhibitor with selectivity against JAK1 and JAK3 (IC50= 1280 and 520 nM, respectively). |
937272-79-2 |
DC8168 |
Peficitinib(ASP015K,JNJ-54781532)
Featured
Peficitinib(ASP015K,JNJ-54781532) is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats. |
944118-01-8 |
DC11734 |
PF-06263276
PF-06263276 (PF06263276, PF 6263276) is a potent, selective pan JAK inhibitor with IC50 of 2.2, 23.1, 59.9 and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively. |
1421502-62-6 |
DC10779 |
PF-06651600
Featured
PF-06651600 is a potent JAK3-selective inhibitor with an IC50 of 33.1 nM. |
1792180-81-4 |
DC12489 |
PF-06700841 free base
Featured
PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus. |
1883299-62-4 |
DC12488 |
PF-06700841 tosylate
Featured
PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus. |
2140301-96-6 |
DC9593 |
Pim1/AKK1-IN-1
PIM/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively; also inhibits MPSK1 and TNIK. |
1093222-27-5 |
DC10047 |
PIM-447 dihydrochloride
Featured
PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase. |
1820565-69-2 |
DC7236 |
Pimobendan
Featured
Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM. |
74150-27-9 |
DC9691 |
Piperlongumine
Featured
Piperlongumine induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53. |
20069-09-4 |
DC8604 |
Pim-1 Inhibitor 2
Potent Pim-1 kinase inhibitor (Ki = 91 nM). |
477845-12-8 |
DC4230 |
Ruxolitinib (INCB018424)
Featured
Ruxolitinib is a potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively and is relatively less selective for JAK3 (IC50 = 322 nM). |
941678-49-5 |
DC8309 |
Ruxolitinib Phosphate
Featured
Ruxolitinib Phosphate is a potent and selective Janus kinase (JAK1, IC50 = 5.9 nM and JAK2, IC50 = 5.7 nM) inhibitor. |
1092939-17-7 |
DC10823 |
SAR-20347
Featured
SAR-20347 is an inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50s of 0.6, 23, 26 and 41 nM, respectively. |
1450881-55-6 |
DC7160 |
SGI-1776
Featured
SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM; 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. |
1025065-69-3 |
DC7983 |
SH-4-54
Featured
SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively. |
1456632-40-8 |
DC10105 |
SH5-07
Featured
SH5-07 is a hydroxamic acid based Stat3 inhibitor with an IC50 of 3.9±0.6 μM in in vitro assay. |
1456632-41-9 |
DC10514 |
SMI-16a
Featured
SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively. |
587852-28-6 |
DC7503 |
SMI 4a
Featured
SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modest potent to Pim-2, does not significantly inhibit other serine/threonine- or tyrosine-kinases. |
438190-29-5 |
DC8169 |
Solcitinib(GLPG0778)
Featured
Solcitinib, also known as GSK2586184 or GLPG0778, is a Janus kinase 1 (JAK1) inhibitor. |
1206163-45-2 |
DC10139 |
Stat5 Inhibitor(STAT5-IN-1)
Featured
Stat5 Inhibitor is a cell permeable nonpetidic nicotinoyl hydrazone which suppresses Stat5 via binding to the SH2 domain. |
285986-31-4 |
DC7514 |
TCS PIM-1 1
Featured
TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM). |
491871-58-0 |