Cat. No. | Product name | CAS No. |
DC7153 |
CX6258
Featured
CX-6258 is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity. |
1202916-90-2 |
DC3107 |
Momelotinib (CYT387,CYT-387)
Featured
CYT387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC50 of 11 nM and 18 nM, respectively. |
1056634-68-4 |
DC10111 |
Debio 0617B
Debio 0617B has been developed as a first-in-class kinase inhibitor with a unique profile targeting phospho-STAT3 (pSTAT3) and/or pSTAT5 in tumors through combined inhibition of JAK, SRC, ABL, and class III/V receptor tyrosine kinases (RTK). |
1332329-27-7 |
DC8171 |
Decernotinib (VX-509,adelatinib)
Featured
Decernotinib(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays. |
944842-54-0 |
DC11890 |
Delgocitinib
Featured
Delgocitinib (JTE-052, LEO 124249) is a potent, selective, orally active, pan-JAK inhibitor with IC50 of 2.8, 2.6, 13 and 58 nM for JAK1,2,3 and Tyk2, respectively. |
1263774-59-9 |
DC8726 |
FLLL31
Featured
FLLK31 is a potent and selective inhibitor of the STAT3 signaling pathway. |
52328-97-9 |
DC7751 |
FLLL32
Featured
FLLL32, a novel curcumin analogue, is a potent STAT3 inhibitor. |
1226895-15-3 |
DC10826 |
FM-381
Featured
FM-381 is a JAK3 specific reversible covalent inhibitor with IC50 of 127 pM for JAK3 and demonstrates 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and TYK2, respectively. |
2226521-65-7 |
DC8375 |
GLPG0634 analogue
Featured
GLPG0634 (analog) is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3; more information can be found in the reference patents. |
1206101-20-3 |
DC7137 |
Filgotinib(GLPG0634)
Featured
GPLG0634 is a novel inhibitor of JAK1 and JAK2 with IC50 of 10nM and 28nM respectively. |
1206161-97-8 |
DC10171 |
Hispidulin
Featured
Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM. |
1447-88-7 |
DC10626 |
HJC0152
HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility. |
1420290-99-8 |
DC10918 |
INCB053914
INCB053914 (INCB-053914) is a novel potent, and selective ATP-competitive, pan-PIM kinase inhibitor with IC50 of 0.24/30.0/0.12 nM for PIM1/2/3, respectively. |
1620012-39-6 |
DC10555 |
inS3-54A18
Featured
inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties. |
328998-53-4 |
DC12378 |
Itacitinib(INCB039110)
Featured
Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis. |
1334298-90-6 |
DC11136 |
JAK2 inhibitor G5-7
Featured
JAK2 inhibitor G5-7 is a small molecule, allosteric JAK2 inhibitor that selectively inhibits JAK2-mediated phosphorylation and activation of EGFR and STAT3 by binding to JAK2. |
939681-36-4 |
DC8077 |
WHI-P131(Janex 1)
Featured
Janex 1 selectively inhibits the tyrosine kinase activity of JAK3 with an IC50 value of 78 µM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases (IC50 ≥350 µM). |
202475-60-3 |
DC7665 |
Gandotinib(LY2784544)
Featured
LY2784544 is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2. |
1229236-86-5 |
DC7195 |
JAK Inhibitor I(Merck 5, Pyridone 6)
Featured
Merck 5 is a potent and reversible ATP-competitive inhibitor of the JAK kinases (JAK1, JAK2, JAK3, and Tyk2). It also blocks IL2 and IL4 dependent proliferation of CTLL cells and inhibits the phosphorylation of STAT5. |
457081-03-7 |
DC8474 |
Napabucasin (BBI608)
Featured
Napabucasin (BBI608) is an orally-administered small molecule which can block cancer stem cell (CSC) self-renewal and induces cell death in CSCs as well as non-stem cancer cells. |
83280-65-3 |
DC10748 |
NSC31205
Featured
NSC 31205 is a PIM2/1 inhibitor. |
6320-51-0 |
DC7216 |
NVP-BSK805 dihydrochloride
Featured
NVP-BSK805 is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM; >20-fold selectivity towards JAK1, JAK3 and TYK2. |
1092499-93-8 |