TCS PIM-1 1|cas 491871-58-0|DC Chemicals|Price|Buy

Cas No.:	491871-58-0
Chemical Name:	SC 204330; TCS PIM 1-1
Synonyms:	SC 204330; TCS PIM 1-1
SMILES:	C1=C(Br)C=CC(O)=C1C1=CC(C2=CC=CC=C2)=C(C#N)C(=O)N1
Formula:	C₁₈H₁₁BrN₂O₂
M.Wt:	367.2
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

TCS PIM-1 1(sc-204330) is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).TCS PIM-1 1 bound convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism. Preliminary data further suggested that 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2 (IC50 > 20 lM). Hence, small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC11436	YLT-11	YLT-11 is a novel and specific PLK4 inhibitor with IC50 of 22 nM and Kd of 5.2 nM.
DC10031	TP-3654	TP-3654 is a small molecule pan-Pim (PIM) kinase inhibitor.
DC7514	TCS PIM-1 1	TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).
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DC7160	SGI-1776	SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM; 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin.
DC7236	Pimobendan	Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
DC10047	PIM-447 dihydrochloride	PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase.
DC10171	Hispidulin	Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.
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