| DC49316 |
L-Ornithine-15N2 hydrochloride |
L-Ornithine-15N2 hydrochloride is the 15N-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen. |
|
| DC49322 |
(S)-L-Cystine-15N2 |
(S)-L-Cystine-15N2 is the 15N-labeled L-Cystine. L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes. |
|
| DC49323 |
L-Histidine-15N3 hydrochloride hydrate |
L-Histidine-15N3 (H-His-OH-15N3) hydrochloride hydrate is the 15N-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite. |
|
| DC49324 |
L-Histidine-15N hydrochloride hydrate |
L-Histidine-15N (H-His-OH-15N) hydrochloride hydrate is the 15N-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite. |
|
| DC49335 |
L-Lysine-15N-1 dihydrochloride |
L-Lysine-15N-1 dihydrochloride is the 15N-labeled L-Lysine. L-lysine is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions. |
|
| DC49344 |
L-Tyrosine-3,5-13C2 |
L-Tyrosine-3,5-13C2 is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex. |
|
| DC49345 |
Octanoic acid-13C |
Octanoic acid-13C (Caprylic acid-13C) is the 13C labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes. |
|
| DC49352 |
Valienamine |
Valienamine is the alpha-glucosidase inhibitor. Valienamine is the key functional component of many natural glycosidase inhibitors including the crop protectant validamycin A and the antidiabetic agent acarbose. |
|
| DC49361 |
L-Tyrosine-13C |
L-Tyrosine-13C is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex. |
|
| DC49362 |
L-Tyrosine-1-13C |
L-Tyrosine-1-13C is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex. |
|
| DC49363 |
L-Tyrosine-4-13C |
L-Tyrosine-4-13C is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex. |
|
| DC49369 |
Endothall |
Endothall (Endothal) is a protein phosphatase 2A (PP2A) inhibitor with IC50s of 90 nM and 5 µM for PP2A and PP1, respectively. Endothall can be used as an herbicide. Endothall also is useful in cancer chemotherapy. |
|
| DC49378 |
rel-Tranylcypromine |
rel-Tranylcypromine (SKF 385) is a potent monoamine oxidase (MAO) inhibitor. |
|
| DC49380 |
L-Tyrosine-17O |
L-Tyrosine-17O is the 17O-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex. |
|
| DC49383 |
Pheniprazine |
Pheniprazine is a potent and long acting inhibitor of monoamine oxidase. Pheniprazine has the potential for the research of depression. |
|
| DC49398 |
Hippuric acid-15N |
Hippuric acid-15N (2-Benzamidoacetic acid-15N) is the 15N-labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food. |
|
| DC49409 |
Glucose oxidase |
Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O2) to produce hydrogen peroxide (H2O2) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation. |
|
| DC49720 |
Guanylyl imidodiphosphate lithium |
Guanylyl imidodiphosphate (Gpp(NH)p) lithium, a non-hydrolyzable GTP analogue, increases adenylate cyclase activity. |
|
| DC49721 |
ALDH1A1-IN-2 |
ALDH1A1-IN-2 is a potent inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1). Aldehyde dehydrogenases (ALDH) constitute a family of enzymes that play a critical role in oxidizing various cytotoxic xenogenic and biogenic aldehydes. ALDH1A1-IN-2 has the potential for the research of cancer, inflammation, or obesity (extracted from patent WO2019089626A1, compound 295). |
|
| DC49722 |
Aldose reductase-IN-3 |
Aldose reductase-IN-3 (Compound 5) is a potent and moderately selective inhibitor of aldose reductase (AR) with an IC50 of 3.99 μM. Aldose reductase has recently emerged as a molecular target that is involved in various inflammatory diseases, including sepsis. Aldose reductase-IN-3 has the potential for the research of sepsis. |
|
| DC49723 |
Aldose reductase-IN-2 |
Aldose reductase-IN-2 (Compound 5f) is a potent inhibitor of aldose reductase (AR). Aldose reductase-IN-2 has antioxidation capacity. Aldose reductase-IN-2 is a promising anti-diabetic complications agent. |
|
| DC49724 |
AD011 |
AD011 is a dual inhibitor of cACE/NEP. AD011 is synthesized based on the previously reported C-domain selective ACE inhibitor lisinopril-tryptophan. AD011 has the potential for providing the potent antihypertensive and cardioprotective benefits. |
|
| DC49725 |
AD012 |
AD012 is a dual inhibitor of cACE/NEP. AD012 is synthesized based on the previously reported C-domain selective ACE inhibitor lisinopril-tryptophan. AD012 has the potential for providing the potent antihypertensive and cardioprotective benefits. |
|
| DC49726 |
AD013 |
AD013 is a dual inhibitor of cACE/NEP. AD013 is synthesized based on the previously reported C-domain selective ACE inhibitor lisinopril-tryptophan. AD013 has the potential for providing the potent antihypertensive and cardioprotective benefits. |
|
| DC49727 |
Human carbonic anhydrase II-IN-1 |
Human carbonic anhydrase II-IN-1 (Compound S-13) is a potent human carbonic anhydrase II (hCA II) inhibitor with a Ki of 4.4 nM. Human carbonic anhydrase II-IN-1 also inhibits other hCAs isoforms I, IV and IX, with Ki values of 9.2 nM, 480.2 nM and 14.7 nM, respectively. Human carbonic anhydrase II-IN-1 can be used for glaucoma research. |
|
| DC49728 |
Human carbonic anhydrase II-IN-2 |
Human carbonic anhydrase II-IN-24 (Compound R-13) is a potent human carbonic anhydrase (hCA) inhibitor with Kis of 60.7, 320.7, 2298, and 35.2 nM for hCA I, II, IV and IX, respectively. |
|
| DC49729 |
Carbonic anhydrase inhibitor 11 |
Carbonic anhydrase inhibitor 11 (compound VI) is a potent, selective carbonic anhydrase inhibitor. Carbonic anhydrase inhibitor 11 shows Ki values of 40, 39, 200 and 900 nM against CA II, IX, and XII, respectively. |
|
| A724 |
Girentuximab
Featured
|
Girentuximab (G250) is a chimeric monoclonal antibody that binds carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC). |
|
| DC49731 |
Carbonic anhydrase inhibitor 9 |
Carbonic anhydrase inhibitor 9 is a potent carbonic anhydrase (CA) inhibitor with Kis of 56.4 and 56.9 nM for hCA II and IX, respectively. Antiproliferative activity. |
|
| DC49732 |
Carbonic anhydrase inhibitor 12 |
Carbonic anhydrase inhibitor 12 is a potent CA II inhibitor, also has inhibitory activity in CA I (Kis of 1.72 and 271 nM in CA II and CA I, respectively). Carbonic anhydrase inhibitor 12 has potent anticancer activity against different cancer cell lines. |
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