| DC48976 |
VULM 1457 |
VULM 1457 is a potent inhibitor of cholesterol acyltransferase (acyl-CoA). VULM1457 significantly reduces production and secretion of adrenomedullin (AM) and down-regulates AM receptors on human hepatoblastic cells. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM 1457 has the potential for the research of diabetes mellitus and hypercholesterolaemia. |
|
| DC48985 |
DX3-234 |
DX3-234 is an oxidative phosphorylation (OXPHOS) inhibitor. DX3-234 shows significant tumor suppression in the Pan02 syngeneic model of pancreatic cancer. |
|
| DC48995 |
BRD2889 |
BRD2889 is an analog of the alkaloid piperlongumine. BRD2889 is a robust modulator of the GSTP1-ISCU axis in pulmonary hypertension (PH). |
|
| DC49006 |
Varioxepine A |
Varioxepine A is a 3H-oxepine-containing alkaloid with a new oxa-cage found in the marine algal-derived endophytic fungus Paecilomyces variotii. Varioxepine A inhibits plant pathogenic fungus Fusarium graminearum. |
|
| DC49011 |
DX3-235 |
DX3-235 is an oxidative phosphorylation (OXPHOS) inhibitor. DX3-235 shows nanomolar inhibition of complex I function and ATP production in a galactose-containing medium resulting in significant cytotoxicity. |
|
| DC49014 |
Glycohyocholic acid |
Glycohyocholic acid(GHCA) is a glycine-conjugated form of the primary bile acid hyocholic acid. |
|
| DC49035 |
Terpendole I |
Terpendole I, a fungal indoloditerpene, is a ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor (IC50=145 µM). |
|
| DC49054 |
ATX inhibitor 8 |
ATX inhibitor 8 is a Autotaxin (ATX) inhibitor extracted from patent WO2018212534A1 compound 96. |
|
| DC49062 |
Tryptoquivaline D |
Tryptoquivaline D is a fungal metabolite from Aspergillus fumigatus. |
|
| DC49090 |
Setosusin |
Setosusin ((+)-Setosusin) is a fungal meroditerpenoid featuring a unique spiro-fused 3(2H)-furanone moiety. |
|
| DC49110 |
Avellanin B |
Avellanin B is a fungal metabolite with pressor effect. |
|
| DC49116 |
L-Ornithine-1,2-13C2 hydrochloride |
L-Ornithine-1,2-13C2 hydrochloride is the 13C-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen. |
|
| DC49117 |
D-Glucose-13C3-1 |
D-Glucose-13C3-1 (Glucose-13C3-1) is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response. |
|
| DC49118 |
D-Glucose-13C3 |
D-Glucose-13C3 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response. |
|
| DC49119 |
H-Tyr(3-I)-OH-13C6 |
H-Tyr(3-I)-OH-13C6 is the 13C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite. |
|
| DC49121 |
L-Tyrosine-13C6 |
L-Tyrosine-13C6 is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex. |
|
| DC49125 |
Toddacoumalone |
Toddacoumalone is a natural inhibitor of phosphodiesterase 4 (PDE4) with moderate potency and imperfect drug-like properties. Toddacoumalone has the potential for the research of inflammatory diseases such as psoriasis. |
|
| DC49129 |
AChE-IN-4 |
AChE-IN-4 shows the acetylcholine esterase inhibition (AChEI) with an IC50 value of 24.1 μM. |
|
| DC49135 |
Cytoglobosin D |
Cytoglobosin D, a cytochalasan derivative, displays cytotoxic activity toward the A-549 cell line (IC50=2.55 μM). |
|
| DC49136 |
Cytoglobosin C |
Cytoglobosin C, a cytochalasan derivative, shows potent cytotoxicity against both SGC-7901 and A549 cell lines (IC50<10 μM). |
|
| DC49164 |
Burnettramic acid A aglycone |
Burnettramic acid A aglycone is a fungal metabolite found in Aspergillus burnettii. |
|
| DC49181 |
Hydroxy ritonavir |
Hydroxy ritonavir is a metabolite of Ritonavir. Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS. |
|
| DC49190 |
Trichodecenin I |
Trichodecenin I, a fungal metabolite, is a peptaibol composed of 7 amino acid residues. |
|
| DC49201 |
Zaragozic acid B |
Zaragozic acid B, a fungal metabolite, is a potent inhibitor of both farnesyl-protein transferase (FPTase) and squalene synthases. Zaragozic acid B is a potential anticancer drug. |
|
| DC49202 |
β-Alanine-15N |
β-Alanine-15N (2-Carboxyethylamine-15N) is the 15N-labeled β-Alanine. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer. |
|
| DC49203 |
Sarcosine-15N |
Sarcosine-15N (N-Methylglycine-15N) is the 15N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia. |
|
| DC49204 |
L-Serine-15N |
L-Serine-15N ((-)-Serine-15N) is the 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation. |
|
| DC49205 |
Calcium glycerophosphate |
Calcium glycerophosphate is an inhibitor of intestinal alkaline phosphatase F3. Calcium glycerophosphate is a source of calcium and phosphorus in total parenteral nutrition solutions. |
|
| DC49210 |
Zaragozic acid E |
Zaragozic acid E, a fungal metabolite, is a potent inhibitor of squalence synthetase with IC50s of 2.3-28 nM. |
|
| DC49215 |
D-Glucose-13C2-4 |
D-Glucose-13C2-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response. |
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