Novel probe for neurofibrillary tangles (tau fibrils)

Novel potent and selective inhibitor of kynurenine aminotransferase II

Novel, systemically active kynurenine aminotransferase 2 (KAT2) inhibitor, significantly decreased escape latency in the Morris water maze, indicating improved performance in spatial and contextual memorynovel

Potent inhibitor of centrosomal clustering in malignant cells

Novel Aldose_reductase_inhibitor>aldose reductase (ALR2) inhibitor

Novel dual inhibitor of norepinephrine transporter (NET) function and thyrointegrin αvβ3 receptor

The first small-molecule substrate identified with high selectivity for BGT1 over the three other GAT subtypes; M1 muscarinic agonist

Cell-permeable apoptosis inducer, specifically preventing BH3 domain-mediated interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family

Reactive dark quencher used in a variety of Fluorescence Resonance Energy Transfer (FRET) DNA detection probe.

Novel photoactivatable form of serotonin

Novel PROTAC (proteolysis-targeting chimera) as a PTK2 protein degerader

Novel fluorophore substrate of the protease Cathepsin C (CatC), being highly selective versus the related proteases CatB, CatF, CatH, CatK, CatL and CatS

Novel potent inhibitor of human chymase with >100 fold selectivity against Cathepsin G

Novel highly selective, soluble and cellular permeable inhibitor of the P. falciparum protease dipeptidyl aminopeptidase 1 (DPAP1)

Novel inhibitor of HIV replication, preventing the formation of the capsid core structure that encapsulates the viral genome and its associated enzymes, reversing transcriptase and integrase

Novel potent and selective inhibitor of Alk5 (TGFßR1), blocking the phosphorylation of Smad2 and Smad3 in HaCaT cells

Novel potent and selective ATP-competitive inhibitor of glycogen synthase kinase (GSK-3), targeting both isoforms GSK-3α and GSK-3β

Novel highly potent dual inhibitor of BRD9/BRD7

Novel RORγ antagonist for the treatment of autoimmune diseases

Non-ATP competitive inhibitor of JNK, targeting the JNK-JIP interaction

Novel potent, highly selective, and orally bioavailable CATHEPSIN C (CTSC, CatC) inhibitor

Novel nonpeptide angiotensin II receptor antagonist

Novel, highly selective and potent irreversible BTK inhibitor

Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase

Triple reuptake inhibitor (TRI)

Antilipidemic agent

GABAA receptor antagonist

Novel inhibitor of the TGF-β pathway, blocking the epithelial to mesenchymal transition

Partial agonist at dopamine D2 and serotonin 1A receptors

Novel selective heat shock protein 90 inhibitor, prodrug of CF2772

Selective Syk inhibitor

Novel, Selective, Potent, Reversible Bruton's Tyrosine Kinase (BTK) Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases

Novel potent blocker of the NMDA receptor ion channel

Novel potent blocker of Nav1.2 sodium channels, protecting of brain tissue from ischemia

Natural Biliary Toxin, causing extrahepatic biliary atresia

Potent HNF4α antagonist

Novel USP28 inhibitor

Novel selective RORgamma inhibitor, selectively inhibiting Th17 differentiation and RORgamma signature gene expression

Novel heparanase inhibitor

Potent inhibitor of SHIP-2 catalytic activity; Novel inositol polyphosphate surrogate modulating Ca responses in rat hepatocytes

Potent peptide opioid receptor agonist, alleviating LPS-Induced activation in rat primary microglial cultures in opioid receptor-dependent and receptor-independent manners

Novel adjuvant to repurpose azithromycin for use against Pseudomonas aeruginosa, exhibiting a 1024-fold reduction in the minimum inhibitory concentration of azithromycin in vitro and displays activity in a Galleria mellonella model of infection

Novel anti-HIV active dimeric prodrug of 2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine monophosphate (d4TMP)

Class I antiarrhythmic agent with chronotropic, inotropic, dromotropic and coronary vasodilator effects, potently blocking sodium channel

Novel anti-HIV active dimeric prodrug of 2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine monophosphate (d4TMP)

Selective hAMCase Inhibitor

Novel inhibitor of angiogenesis by regulating STAT3 and VEGF in breast cancer cells

Novel and selective Wnt signaling inhibitor

Novel inhibitor of LPS-induced inflammation in macrophages, improving survival in sepsis

UV stabilizer

Potent activator of the Neh2-luc reporter

Novel Orally Efficacious Pan-HDAC Inhibitor

Inactivator of GSTP1>GST P1-1 through the covalent modification of two Cys47 residues per dimer and one Cys101

Novel potent antagonist of RORγt function, displaying an increased selectivity for RORγt over RORα and PPARγ compared to the purely orthosteric and allosteric non-PEG-linked parent compounds

Potent and selective dual inhibitor of MEK5 and ERK5

Potent inhibitor of recombinant human and mouse Transglutaminase enzyme activity, mainly TG2 and the close related enzyme TG1

Novel potent and selective covalent Pin1 inhibitor

Novel Bumped-Kinase Inhibitor (BKI) for Cryptosporidiosis Therapy

Novel Bumped-Kinase Inhibitor (BKI) for Cryptosporidiosis Therapy

Novel potent and selective bumped kinase inhibitor (BKI) CpCDPK1 IC 50 0.0025 µM

Novel potent and selective bumped kinase inhibitor (BKI) CpCDPK1 IC 50 0.005 µM

Novel inhibitor of survivin transcription through a signal transducer and activator of transcription 3 (Stat3)-dependent mechanism, inhibiting tissue expression of survivin and inducing apoptosis in C4-2 skeletal tumor

Novel effective inhibitor of survivin expression at both the mRNA and protein levels in vitro, significantly reducing survivin in bone metastatic C4-2 tumors

Novel inhibitor of the expression of anti-apoptotic protein survivin and membrane-bound efflux pump ATP binding cassette B 1 (ABCB1, p-glycoprotein), presumably via signal transducer and activator of transcription 3 (Stat3), inhibiting human prostate canc

Bradykinin antagonist, causing impressive growth inhibition of lung and prostate tumors, displaying superior in vivo inhibitory effects than convential chemotherapeutic drugs

Natural anti-coronavirus agent

Natural Potent 14-3-3 inhibitor

Potent 14-3-3 inhibitor

Novel ERK inhibitor, inducing breast cancer cell apoptosis via mitochondrial pathway but independent on Ras/Raf/MEK pathway

Inhibitor of calpain, cathepsin L and cathepsin B

Inhibitor of Marburg virus (MARV) growth at noncytotoxic concentrations

Original TXA2 modulator, inhibiting the action of thromboxane A2 and 8-iso-prostaglandin F2alpha

Dual thromboxane synthase inhibitor and thromboxane receptor antagonist

Novel potent EGFR inhibitor

Novel LRP5/6-sclerostin interaction inhibitor, recovering the downregulated activity of the Wnt/β-catenin signaling pathway by competitive binding to the LRP5/6-sclerostin complex

Novel inhibitor of RNA polymerase I, causing nucleolar stress and showing potent anticancer activity across many tumor types

Novel potent cyclin-dependent kinases (CDK) inhibitor, inducing a strong cell cycle alteration

Potent and selective inhibitor of Cdk5/p25, protecting large population of cells against non-A

Metabolite of BML277 which is a selective checkpoint kinase 2 inhibitor

Novel activator of BMP signaling, enhancing osteoblast differentiation, targeting HECT domain of ubiquitin ligase Smurf1, up-regulating the protein level of Smad1/5

Novel activator of BMP signaling, enhancing osteoblast differentiation, targeting HECT domain of ubiquitin ligase Smurf1, up-regulating the protein level of Smad1/5

Novel Highly Selective LRRK2 Inhibitor

Novel PD-L1 Inhibitor

Novel PD-1/PD-L1 Inhibitor

Novel potent, selective inhibitor of AAK1 (adaptor associated kinase 1), having the appropriate combination of solubility and charge required for microiontophoresis

5HT1B/1D agonist

Novel K channel opener; Glyburide-Reversible Cardioprotective Agent with Minimal Vasodilator Activity

Novel antifungal and fungicidal agent

Quantity (mg or Unit) Unit Price ($/mg or $/Unit) Final Price 100 $13.95 Total: $1,395.00 50 $16.12 Total: $806.00 25 $18.91 Total: $472.75 10 $22.32 Total: $223.20 5 $26.35 Total: $131.75

Novel selective inhibitor of RARγ

Squalene synthase inhibitor

Retinoic acid receptor (RAR) pan-antagonist

Novel and selective neuropeptide Y1 receptor antagonist

Novel potent inhibitor of the ATP hydrolase activity of mitochondrial F1F0 ATP synthase

Potent and selective β3 full agonist

Potent and selective p56(lck) inhibitor

Selective ATP hydrolase inhibitor

Potent and selective beta-lactam tryptase inhibitor, inhibiting factor XIa and producing antithrombotic efficacy with minimal bleeding time prolongation

Highly potent and selective phosphodiesterase 5 (PDE 5) inhibitor

Novel fluoro-substituted camptothecin, inducing topoisomerase I-mediated DNA breaks

Novel dissociated glucocorticoid receptor modulator

Novel Selective CYP17A1 Lyase Inhibitor

Prodrug of the novel fluoro-substituted camptothecin analog, BMS-286309

Novel Inhibitor of human immunodeficiency virus type 1 (HIV-1) attachment

Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor

Novel, potent, exceptionally selective inhibitor of TNF-α Converting Enzyme (TACE)

Novel Inhibitor of human immunodeficiency virus type 1 (HIV-1) attachment

Novel potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1)

Novel Novel γ-secretase modulator, decreasing Aß1-40 and Aß1-42 and increasing Aß1-37 and Aß1-38 in rat brain modulator, decreasing Aß1-40 and Aß1-42 and increasing Aß1-37 and Aß1-38 in rat brain

Novel potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1)

Novel potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1)

Potent, Orally Bioavailable, Metabolically Stable Thumb Site 1 Inhibitor of the Hepatitis C Virus NS5B RNA-Dependent, RNA Polymerase

Novel potent and selective P2Y1 purinergic receptor antagonist.

Novel inhibitor of the influenza nucleoprotein (INF-NP)

Potent alpha7 Nicotinic receptor partial agonist, improving cognition in preclinical rodent model

Potent and selective GPR119 agonist

Novel Agonist of Sphingosine-1-Phosphate (S1P1)

Selective RARγ agonist

Novel GPR119 agonist

Novel S1P1 receptor modulator

Novel γ-secretase modulator

Novel pan-genotype inhibitor of HCV NS5B polymerase via binding to the primer grip site

G-quadruplex ligand, decreasing oncogene expression

Novel fluorescent activity-based probe (ABP), being intrinsically dark and only emitting fluorescence after reaction with the target protease, are ideally suited for imaging techniques such as small animal noninvasive fluorescence imaging and live cell fl

Potent long-acting H2-receptor antagonist

Novel CD4 mimic, inhibiting HIV-1 entry into target cells with both significantly higher potency and neutralization breadth than previous congeners, while maintaining high selectivity for the target virus

Solvatochromic Nile Red Probe with FRET Quencher Reveal Lipid Order Heterogeneity in Living and Apoptotic Cells

Selective delta 1 opioid receptor antagonist

Inhibitor of topoisomerase I/II, inducing DNA cross-linking and significantly suppressing the growth of various NSCLC cell lines with or without mutations in epidermal growth factor receptor (EGFR)

Novel covalent substrate-competitive inactivator of AKT kinase

Novel Fluorescent, Highly Affine Histamine H3 Receptor Ligand

Fluorogenic dye for Live-Cell Fluorescence Microscopy

Novel fluorogenic dye for Live-Cell Fluorescence Microscopy

Natural inhibitor of protein tyrosine phosphatase 1B (PTP1B)

Potent Botulinum Neurotoxin A Light-Chain Inhibitor

Novel potent inhibitor of Botulinum neurotoxin/A light chain (BoNT/A LC)

Novel BOP-conjufated fluorescent dual α9β1/α4β1 integrin inhibitor

Novel. highly potent, selective, cell-permeable furin inhibitor, rescuing key features of cystic fibrosis airway disease

Proteolysis targeting chimeras (PROTAC), acting as a degrader of oncogenic BCR-ABL

Novel IKK-2 inhibitor, targeting the Ser177 and/or Ser181 residues in the kinase's activation loop domain.

Novel and highly potent histamine H3 receptor ligand

Potent and selective STAT5 inhibitor

Novel, Potential Dengue Virus NS2B/NS3 Protease Inhibitor

Histamine H3 receptor agonist prodrug

Novel modulator of TTD-PHD histone reader module, binding to the TTD groove, competing with linker binding and promoting open TTD-PHD conformations

Novel potent SQS inhibitor

Novel CrtM inhibitor

Squalene synthase (SQS) inhibitor, potently inhibiting CrtM

The first potent inhibitor of Burkholderia pseudomallei methionine aminopeptidase

Novel RBP4 antagonist with good in vitro potency and selectivity and optimal rodent pharmacokinetic (PK) and pharmacodynamic (PD) characteristics

Novel potent and selective dual FLT3/AURKA inhibitor

Potent direct PTEN inhibitor

Potent and se;rctive PTEN inhibitor, activating the insulin receptor kinase, inhibiting the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors of rat liver endosomes

Novel apoptosis signal-regulating kinase 1 (ASK1) inhibitor with IC50 of 0.52μM in vitro in kinase assay

Novel potent inhibitor of human neutrophil activations

Quantity (mg or Unit) Unit Price ($/mg or $/Unit) Final Price 100 $292.50 Total: $29,250.00 50 $338.00 Total: $16,900.00 25 $396.50 Total: $9,912.50 10 $468.00 Total: $4,680.00 5 $552.50 Total: $2,762.50

Monoamine Reuptake Inhibitor

Inhibitor of cyclobrassinin hydrolase, a unique enzyme from the fungal pathogen Alternaria brassicicola

Natural small molecule isolated from dried heartwood of Caesalpinia sappan L, exhibiting multi-pharmacological activities

Novel multistage antimalarial inhibitor

Novel Inhibitor of Clostridium difficile

Novel potent inhibitor of spCas9, disrupting spCas9-DNA binding and exerting dose and temporal control of spCas9 in human cell lines

Novel HDAC inhibitor, inhibiting multiple HDAC enzymes and modulates acetylation levels in cells

Positive control for HSPC toxicity; Inhibitor of STK33

Negative control for tubastatin A

Novel inhibitor of parasite phenylalanyl-tRNA synthetase (PheRS)

Novel non-histone nuclear substrate of histone deacetylase 8 (HDAC8)

Novel selective BET BD1 inhibitor with preferred binding to of BRD4 BD1

Novel potent inhibitor of BRD4 BD2

Novel potent BRD4 D1 inhibitor with over 500-fold selectivity against BRD2 D1 and BRD4 D2 via ITC

Negative control in HDAC1/2/3/8 assays

Novel HDAC8 inhibitor

Novel Mitochondrial Content Inducer

Novel dihydroorotate dehydrogenase (DHODH) inhibitor

Novel multistage antimalarial inhibitor for single-dose treatment of malaria in mouse models

Novel specific inhibitor of the hypomorph growth

Novel inhibitor of dihydroorotate dehydrogenase (DHODH), showing in vitro activity against multidrug-resistant blood-stage parasites

Novel specific inhibitor of the hypomorph growth of EfpA, a largely uncharacterized, but essential efflux pump in Mtb

Novel water-soluble, DNA-binding photosensitizer for the eradication of both Gram-negative and Gram-positive bacteria

Active-site-directed inactivator of bacterial beta-lactamases

Highly κ/μ-selective potent κ ligand

Reversible inhibitor of monoamine oxidase A, acting on epinephrine, norepinephrine, serotonin, and dopamine

Inhibitor of the reuptake of both dopamine and serotonin in the brain

Mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.

Antitumor agent

Novel PTP1B inhibitor

Novel Ca V channels blocker, binding in the central cavity of the pore on the intracellular side of the selectivity filter, physically blocking the ion-conducting pathway

Protein kinase C (PKC) activator

Novel proteasome inhibitor, protecting against cerebral ischaemia through HIF1A accumulation and enhanced angioneurogenesis

Fluorescent probe in vitro and in vivo aiming at a tau-based diagnosis of Alzheimer's disease

Fluorescent probe, binding to neurofibrillary tangles with high contrast and selectivity over amyloid

Fluorescent probe visualizing neurofibrillary tangles in Alzheimer's disease

Novel potent covalent inhibitor of gut bacterial bile salt hydrolases (BSH)

Novel potent inhibitor of both HIV-1 and HIV-2 replication, being also active against the erythrocytic stages of P. falciparum

Novel respiratory syncytial virus (RSV) fusion inhibitor

Novel cell-permeable modulator of cellular morphogenesis in yeast and mammalian cells; Inhibitor of SARS-CoV Mpro activity via intensive H-bond network and hydrophobic interactions

Novel cell-permeable modulator of cellular morphogenesis in yeast and mammalian cells

Novel activator of PC1/3 and inhibitor of PC2

Novel activator of BtGH84, the first experimentally discovered small molecule activator of a glycoside hydrolase

Novel selective and potent competitive inverse agonist of human GPR43