Liver specific thyromimetic agonist of thyroid hormone receptor-

Broad spectrum matrix metalloproteinase (MMP) inhibitor

Mutant firefly luciferase variant with enhanced light emission

Matrix metalloproteinase (MMP) inhibitor

Water soluble CycLuc3, mutant firefly luciferase variant with enhanced light emission

Benzodiazepine antagonist

Benzodiazepine receptor partial agonist

The first small-molecule based MCM2-targeted NIR-II probe

Novel Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitor

Novel microtubule polymerization inhibitor with little susceptible to transporter-mediated chemoresistance

Novel Hsp90 inhibitor

Potent Androgen_receptor>androgen receptor (AR) pure antagonist which did not produce the agonist metabolite

Novel Hsp90 inhibitor

Novel inhibitor of mitochondrial respiration, targeting drug-resistant cancer cells with stem-like features by inhibiting mitochondrial respiration complex I (NADH:ubiquinone oxidoreductase, complex I [CI])

The desmethyl precursor of CHDI-180R which is a first-in-class high-affinity PET imaging ligand specific for mHTT aggregates

Novel potent and selective kynurenine mono-oxygenase (KMO) inhibitor

Novel intracellular chelator, disrupting iron homeostasis in bacteria

Novel inhibitor against Lactate Dehydrogenase (LDH) of Cryptosporidium parvum

Inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase

Novel potent and orally active ChemR23 inhibitor (IC 80 = 12 nM), showing a long-acting effect in cynomolgus monkeys

Novel dual inhibitor of cholinergic dysfunction and amyloid deposition for AD treatment, penetrating the blood-brain barrier (BBB) and enhancing the cerebral acetylcholine level

Novel acetylcholinesterase inhibitor

Potent, tissue-selective estrogen receptor modulator

Potent, long-acting, and selective muscarinic M3 receptor antagonist

Novel Potent and Selective Chikungunya Virus Envelope Protein Inhibitor

Novel potent inhibitor of HIV-1 integrase

Antiviral and antifungal agent

Widely used biocidal agent

Sympathomimetic agent, facilitating the release of catecholamines, especially noradrenaline and dopamine, from nerve terminals in the brain and also inhibiting their uptake

Serotonin transporter substrate

Hydrophilic prodrug of CHM-1

Novel potent and highly selective irreversible Brutons tyrosine kinase (BTK) inhibitor, inhibiting BTK Y223 auto-phosphorylation

Potent and selective FLT3 inhibitor

Novel Potent Fms-like Tyrosine Kinase 3 Internal Tandem Duplications (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia

Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of c-KIT Kinase for Gastrointestinal Stromal Tumors

Antioxidant; Aldose reductase inhibitor

Natural phytosterol, showing antidiabetes activities

Potent and selective partial agonist of ecdysone receptor (EcR)

Novel potent BMP potentiator with osteogenic efficacy, enhancing canonical BMP outputs at the expense of TGFβ-Smads in an unprecedented manner

Novel inhibitor of 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via mitochondria protection and NF-κB modulation

Novel inhibitor of superoxide anion (O2(-)) generation; Inhibitor of phospholipase D activation; Modulator of immune cell migration via RhoA activity inhibition; Inhibitor of Rac2 activation in stimulated neutrophils

Novel Non-peptide GLP-1R Agonist, adopting a unique binding mode with a more open receptor conformation at the extracellular face

Novel chymase inhibitor, exhibiting concentration-dependent chymase inhibitory activity

Novel inhibitor of E3 ligase activity of cIAP1, antagonizing c-MYC by stabilizing MAD1 protein in cells

Novel SOCE modulator, displaying selectivity over other calcium channels, such as TRPV1, TRPM8, and voltage-operated calcium channels

Stimulator of nitric oxide release and scavenger of superoxide

Novel Selective Agonist of GPR55

Novel Selective Agonist of GPR55

HIV-1 Rev pre-integration inhibitor

Novel specific anti-VEEV (Anti-Venezuelan Equine Encephalitis Virus) agent

Novel inhibitor against the NS3/4A serine protease of Hepatitis C virus genotype 3

Novel Selective Agonist of GPR55

Antibacterial agent, being effective in treating dapsone resistant leprosy

Blocker of integrin binding to its endothelial receptor (VCAM-1)

Novel inhibitor of Cdc42 that act by blocking nucleotide binding with no effect on RhoA or Rac

Novel lopinavir analogue against COVID-19, forming the most stable complex with the Mpro

Novel Inhibitor of the Major Facilitator Superfamily (MFS) of Efflux Pump Transporters.

Potent inhibitor of cancer cell growth with microtubule-binding activity

Potent inhibitor of ROCK2 enzymatic activity

Novel Stimulator of Hepatitis C Virus NS3 Helicase-Catalyzed ATP Hydrolysis

Potent inhibitor of HIV-1 nucleocapsid (NC)-DNA interaction; specifically bound NC with nanomolar affinity, and showed modest anti-HIV-1 activity in ex vivo cell assays

Potent inhibitor of cancer cell growth with microtubule-binding activity

Novel specific inhibitor of bacterial AddAB helicase-nuclease DNA repair enzyme

Inhibitor of PLAP and TNAP

Inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1); Delayed death inhibitor of the malarial parasite plastid; Inhibitor of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1); Inhibit

Platelet activation inhibitor

Novel 3C-like protease inhibitor of SARS-CoV-2

Altered peptide ligand containing a novel CD4 T-cell epitope of human heat shock protein 60 (83-109)

Cell permeable caged inositol triphosphate, promoting Ca2+-release from internal stores under UV photolysis

Noncompetitive inhibitor of Candida albicans growth and activity of (1-3)-beta-glucan synthase

ß-Adrenergic agonist

5-HT2 antagonist

Agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors

Novel modulator of SLC6A19, robustly, selectively, and reproducibly inhibiting SLC6A19

Broad-spectrum antimicrobial carboxyfluoroquinoline, interfering with the bacterial DNA gyrase, inhibiting the DNA synthesis, and preventing bacterial cell growth

Non-Specific Anticoagulant Reversal Agent

Positive modulator of GABA A receptors

Potent inhibitor of MRSA PK

JBP923 analog, exerting potent therapeutic effect on inflammatory bowel disease (IBD)

Novel, natural auxin efflux inhibitor, promoting lateral root formation

Negative control for VZ185

Polo-like kinase 1 (Plk1) inhibitor

Novel Cell-Permeable STAT3 Inhibitor, targeting the SH2 domain

Biological Active Reagents

Potent and competitive antagonist at the human D3 receptor

Novel potent muscarinic antagonist wirh antimuscarinic antidepressant-like activities, showing modest affinity across the mAChRs when compared to L-687306 and scopolamine

SecA inhibitor, showing antiprotozoal, antibacterial and antifungal effects, inhibiting post-translational protein transport into the endoplasmic reticulum. also Inhibiting ATP-dependant translocation of precursor proteins acrossing a bacterial cell membr

Novel non-ATP competitive allosteric inhibitor of Aurora B kinase, binding in the allosteric site F

Anti-HIF-1alpha agent, inhibiting HIF-1alpha and cellular VEGF proteins

Novel inhibitor of STAT3 activation and dimerization through targeting the phosphotyrosine binding site within the SH2 domain

Stimulator of the production of growth hormone (GH) from the pituitary gland

Long-lasting stimulator of the production of growth hormone (GH) from the pituitary gland

Novel CK2 inhibitor, showing potent CSC inhibitory effects in A549 cells

Novel potent PfNDH2 inhibitor

Novel selective allosteric modulator of the protein kinase CK2, inducing apoptosis and cell death in 786-O renal cell carcinoma cells (EC50 = 5 µM) and inhibiting STAT3 activation even more potently than the ATP-competitive drug candidate CX-4945

Potent, reversible, and ATP-competitive inhibitor of casein kinase-2 (CK2)

Novel potent CK2 inhibitor

Novel CK2 inhibitor, targeting an allosteric pocket, exhibiting an IC50 of 3.4 μM against purified CK2α in combination with a favorable selectivity profile

Novel potent and selective inhibitor of CK2. modulating the aforementioned signaling cascades and counteracting 17-AAG-mediated up-regulation of HSP70 in brain cancer cells

Novel cell-permeable and selective inhibitor of human protein kinase CK2, inducing apoptosis in the prostate cancer cell line LNCaP

Novel inhibitor of CK2α, binding in the ATP pocket

Inhibitor of vascular adhesion molecule-1 (VCAM-1), HMGB1 phosphorylation, iNOS expression, NFkB activation; Antiinflammatory

Natural Dual Inhibitor for Wild Type and D816V Mutant of c-KIT Kinase

Negative control for CK156

Inhibitor of H5N1 avian influenza A virus infection

Inhibitor of respiratory syncytial virus (RSV)

Novel potent inhibutor of HIV-1 integrase

Novel protein tyrosine phosphatase-1B (PTP1B) inhibitor, neutralizing the toxicity of α-hemolysin, inhibiting β-secretase 1 (BACE1)-mediated insulin receptor cleavage

The most potent clathrin terminal domain-amphiphysin inhibitor reported to date

Natural modulator of voltage-gated sodium (NaV) channels

Novel two-photon polarity-sensitive lipid membrane probe

Antibiotic, acting as a mechanism-based β-lactamase inhibitor

Novel hypoxia-inducible factor (HIF)-1 inhibitor

Prostaglandin I2 analogue, dose-dependently inhibiting human and rabbit platelet aggregation and human platelet adhesion in vitro

Potent CLK1 and CLK2 inhibitor, also inhibiting SRPK1 and SRPK2

Potent and selective CLK1 and CLK2 inhibitor

Novel inhibitor of the human enzyme dimethylarginine dimethylaminohydrolase-1 (DDAH-1)

Corticosteroid Hormone Receptor Agonist

Hypolipaemic agent, reducing hypertriglyceridemia and hypercholesterolemia

Herbicide safener that is added to various herbicide formulations to reduce crop damage

Long-acting benzodiazepine, producing the active metabolite desmethyl-diazepam, which is a partial agonist of the GABAA receptor

Full agonist of GABAA receptors, acting as anxiolytic, sedative, hypnotic, amnesic, anticonvulsant and muscle relaxant agent

Precursor for tumor selective PET imaging (124I-CLR1404) or therapeutic radiation (131I-CLR1404)

Novel chromophore-linked metallo-β-lactamase (MBL) substrate as potential inhibitor against a panel of clinically relevant MBLs

Novel inhibitor of

Novel potent and selective dual inhibitor of c-Met and ALK, potently abrogating hepatocyte growth factor (HGF)-induced c-Met phosphorylation and cell migration, phosphorylation of ALK, EML4-ALK, and ALK resistance mutants in transfected cells

Novel selective agonist of cannabinoid CB2 receptors

Novel Matrix Metalloproteinase Inhibitor As a Potent Antihemorrhagic Agent

First-in-class dual PDE5 and HDAC6-selective inhibitor

Novel Epigenetic Inhibitor Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myeloma

Novel inhibitor of

Novel Hedgehog pathway inhibitor, revealing the receptor GPR39

Novel Potent and Specific Target Of Rapamycin Complex 2 (TORC2) Inhibitor

Novel ultrapotent and selective inhibitor of of human β-Factor XIIa

Novel peptide STAT5 inhibitor, blocking IL-2/sIL-2Rα signaling and inhibiting T reg cell development

Novel SARS-CoV Mpro inhibitor which has its P1-phenylalanine residue bound to the relatively hydrophilic S1 pocket of the enzyme and yet exhibits a high inhibitory activity against SARS-CoV Mpro, with Ki = 2.24 ± 0.58 μM

Potent dual 5-lipoxygenase (5-LOX) inhibitor and platelet-activating factor (PAF) receptor antagonist

Inhibitor of DprE1, an epimerase required for cell wall biosynthesis

Novel allosteric modulator of the β2 adrenergic receptor (β2AR), binding to a pocket formed primarily by the cytoplasmic ends of transmembrane segments 1, 2, 6 and 7 as well as intracellular loop 1 and helix 8

Selective and potent potentiator of nAChRs containing an α4

Novel TRPV1 modulator, also modulating both CB1 and CB2 receptors

Novel Inhibitor for RNA-Dependent RNA Polymerase of Norovirus

Novel Potent Inhibitor of the HIV-1 Nucleocapsid Protein

Novel Zika virus (ZIKV) NS2B-NS3pro protease inhibitor

Novel blocker of binding of CXCL12 to CXCR4

Novel partial blocker of GluK1, with GluK2 being unaffected

Novel potent and selective blocker of the calcineurin-NFAT interaction (KD=16nM), preventing acute lung injury, being a promising novel treatment for ARDS and other inflammatory diseases

N-methyl-D-aspartate (NMDA) receptor ligand, selectivity targeting the intrachannel PCP/ketamine/MK-801 site of NMDA receptor

Novel and selective noncompetitive antagonist of the NMDA

Novel potent RIPK1/necroptosis ligand, penetrate the blood-brain barrier

Novel inhibitor of mitogen-activated protein kinase (MAPK)

Bioluminescent probe

Natural lariat depsipeptide, inhibiting VEGFA/VEGFR2 expression and suppressing tumor growth in glioblastoma xenografts, targeting Sec61 to prevent biogenesis of secretory and membrane proteins

Novel potent and selective inhibitor of the interaction between Hsp47 and collagen

Novel potent and selective inhibitor of the interaction between Hsp47 and collagen

Novel potent and selective inhibitor of the interaction between Hsp47 and collagen

Natural differentiation inducer of human promyelocytic leukemia cells

Inhibitor of tubulin polymerization, preventing cancer cells from producing microtubules

Inhibitor of tubulin polymerization; vascular disrupting agent (VDA)

Inducer of G2/M-phase cell cycle arrest and cell death in cancer cell lines

Dual inhibitor of phospholipid transfer protein and microsomal triglyceride transfer protein

Novel inducer of Klotho (KL) expression

Natural triketide pyrone, functioning as a sulfate shuttle and its sulfated derivative being accepted as donor molecules by the PAPS-independent arylsulfate sulfotransferase (ASST) Cpz4 to yield sulfated caprazamycin intermediate

A mixture of estrogen hormones used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women, being also used to replace estrogen in women with ovarian failure or other conditions tha

Novel fluorescent copper probe

Novel potent and selective melanocortin-4 receptor inhibitor, possessing 15-fold selectivity for the MC4R versus the MC3R

Novel positive allosteric modulator of the GABA(B) receptor

Novel positive allosteric modulator of the GABA(B) receptor

Natural potent cytotoxic agent against multiple cancer cell lines, acting on cells as a protein synthesis inhibitor, targeting the eukaryotic translation elongation factor 1A (eEF1A), a target shared by other lipophilic cyclic peptide natural products

Novel photoCORM, exhibiting good cellular uptake and real-time monitoring ability of CO uncaging by a color change approach in cancerous B16F10 cells

Novel class I mutation corrector, rescuing CFTR mutations in nucleotide-binding domain 1 (NBD1) by modulating proteostasis

Selective glucocorticoid receptor antagonist

Preformed water-soluble complex of corticosterone and 2-hydroxypropyl-β-cyclode​xtrin

Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling#212121; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; whi

Novel Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis

Novel Potent Mitochondria-Targeted Photodynamic Therapy Anticancer Agent

Novel viral propagation inhibitor, binding to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE), stabilizing the hairpin's folded state and reducing frameshifting efficiency in cells

Potent and selective leukotriene B4 antagonist

Novel potent and selective p38alpha inhibitor

Inhibitor of glycogen phosphorylase; Antidiabetic

Inhibitor of Kv1.3 potassium ion channels

Novel selective α5 GABA A receptor agonist

Novel Mdr1 P-glycoprotein substrate

Potent PPARα agonist with a Ki of 10.8 nM

Novel nonnucleoside reverse transcriptase inhibitor (NNRTI)

Novel inhibitor of against human liver FBPase (IC50, 0.029±0.006 μM) and high selectivity relative to the other six AMP-binding enzymes, producing significant glucose-lowering effects on both type 2 diabetic KKAy mice and ZDF rats

Novel non-RBD binding modulator to inhibit SARS-CoV-2 by prohibiting the conformational change of the spike (S) protein

Novel potent inhibitor of CpFIKK catalytic activity

Novel selective inhibitor of the CREB binding protein (CBP)

Unique inhibitor of MDM2, inhibiting MDM2-p53 interaction and promoting MDM2 degradation

Novel CpIMPDH inhibitor

Novel selective NADPH oxidase 2 (Nox2) inhibitor, attenuating endothelial cell inflammation and vessel dysfunction and restoring mouse hind-limb flow

Novel selective NADPH oxidase 2 (Nox2) inhibitor, attenuating endothelial cell inflammation and vessel dysfunction and restoring mouse hind-limb flow

Novel positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGlu5)

Novel inhibitor of death-associated protein kinase 1 (DAPK1), also inhibiting VEGF-receptor 2 and tyrosine-protein kinase SRC

Novel endothelin receptor antagonist, suppressing the upregulation of matrix metalloproteinases and connexin 43 in hyperthyroid myocardium

Novel potent and selective fluorescent inhibitor of glutaminase (GLS1)

Liposomal-encapsulated combination of daunorubicin and cytarabine for the treatment of newly diagnosed tAML or AML with myelodysplasia-related changes (AML-MRCs)

Novel RORγt inhibitor, suppressing Th17 cell differentiation, reducing the severity of experimental autoimmune disease models such as EAU, EAE, and type 1 diabetes

Novel RORγt inhibitor, suppressing Th17 cell differentiation, reducing the severity of experimental autoimmune disease models such as EAU, EAE, and type 1 diabetes