| DC7368 |
AZD5363
Featured
|
AZD5363, a novel pyrrolopyrimidine-derived compound, inhibits all AKT isoforms (IC50 <10 nM). |
|
| DC20716 |
AZD5576 |
AZD5576(AZD 5576) is a potent, highly selective, and orally bioavailable inhibitor of CDK9 with IC50 of < 5 nM, decreases phosphorylation of Ser2-RNAPII in cells with an IC50 of 96 nM. |
|
| DC22009 |
AZD5718
Featured
|
AZD5718 (AZD-5718, AZD 5718) is a novel potent 5-lipoxygenase activating protein (FLAP) inhibitor with binding IC50 of 6.3 nM; exhibits LTB4 inhibition in human whole blood assays with IC50 of 39 nM; reduce the production of pro-inflammatory and vasoactive leukotrienes both in vitro and in vivo. |
|
| DC20728 |
AZD-5718 |
AZD-5718 is an orally available small molecule, 5-lipoxygenase activating protein (FLAP) inhibitor.. |
|
| DC22007 |
AZD5904 |
AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM, similar potency in mouse and rat. |
|
| DC12553 |
AZD6088 |
AZD6088 (AZD-6088) is a potent and selective, orally bioavailable partial agonist of the M1 muscarinic receptor, reduces heat hyperalgesia in SNL rats with an EC50 of 46.6 nM.. |
|
| DC20731 |
AZD-7325
Featured
|
AZD-7325 is a potent, α2/3 functionally selective, partial GABAA receptor modulator with pKi of 9.51. |
|
| DC8837 |
AZD-7547
Featured
|
AZD7545 is a novel, selective small-molecule inhibitor of PDHK2 (PDH kinase2) with an IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2 respectively. |
|
| DC20714 |
AZD-7594
Featured
|
AZD-7594 (AZ-13189620) is a potent, nonsteroidal, selective glucocorticoid receptor modulator (SGRM) with binding IC50 of 0.9 nM, shows no affinity for AR, PR, MR and ERα/β. |
|
| DC20242 |
AZD-7624
Featured
|
AZD-7624 a potent, selective, inhaled p38α MAPK inhibitor for the treatment of chronic obstructive pulmonary disease. |
|
| DC20733 |
AZD-8165 |
AZD-8165 is a potent, selective and oral thrombin inhibitor for treatment of thrombosis.. |
|
| DC20734 |
AZD-8309 |
AZD-8309 (AZD8309) is a potent and orally bioavailable CXCR2 antagonist that has been proposed to regulate the transmigration of neutrophils. |
|
| DC20735 |
AZD 8329 |
AZD8329 is a potent, selective 11β-HSD1 inhibitor with IC50 of 9 nM, displays excellent selectivity versus relatedd 11β-HSD2, 17β-HSD1 and 17β-HSD3 (IC50>30 uM). |
|
| DC23437 |
AZD-8529
Featured
|
AZD8529 is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes. |
|
| DC23408 |
AZD-8529 mesylate
Featured
|
AZD8529 is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes. |
|
| DC10202 |
AZD8797
Featured
|
AZD8797 is an allosteric non-competitive modulator of the human CX3CR1 receptor; antagonizes CX3CL1 with IC50 values of 6 and 300 nM in B-lymphocyte cell line and human whole blood, respectively. |
|
| DC20737 |
AZD-9819 |
AZD-9819 is an inhibitor of human neutrophil elastase for potential treatment of chronic obstructive pulmonary disease.. |
|
| DC10245 |
Azelaic acid |
Azelaic acid is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. |
|
| DC8338 |
Azeliragon（PF-04494700,TTP488）
Featured
|
Azeliragon is an oral, small-molecule inhibitor of RAGE. |
|
| DCAPI1590 |
Azelnidipine |
Azelnidipine is an L-type calcium channel protein inhibitor |
|
| DC20156 |
Azetidine-2-carboxylic acid
Featured
|
Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent. |
|
| DC4141 |
Azocosterol 2HCL |
Azocosterol is a potential avian reproductive inhibitor. |
|
| DCAPI1225 |
Azomycin (2-Nitroimidazole) |
Azomycin (2-Nitroimidazole) |
|
| DC9818 |
Azoramide
Featured
|
Azoramide is a small-molecule modulator of the unfolded protein response with antidiabetic activity. |
|
| DC12497 |
(Z)-Azoxystrobin
Featured
|
Azoxystrobin is a systemic, broad-spectrum fungicide belonging to the class of methoxyacrylates,which are derived from the naturally-occurring strobilurins. |
|
| DC22953 |
AZSMO-23 |
AZSMO-23 (AZSMO 23, AZSMO23) is a potent hERG potassium channel (Kv11.1) activator that activates WT hERG pre-pulse and tail current with EC50 of 28.6 and 11.2 μM respectively. |
|
| DCAPI1341 |
Aztreonam (Azactam, Cayston) |
Aztreonam (Azactam, Cayston) |
|
| DC21570 |
Azvudine
Featured
|
Azvudine (RO 0622) is a potent HCV NS5B RNA polymerase inhibitor, inhibits HCV replication in the replicon system with IC50 of 24 nM; inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations (IC50=10-100 nM). |
|
| DC23756 |
Aβ polymerization stimulator O4 |
Aβ polymerization stimulator O4 is an orcein-related small molecule can drive polymerization of amyloid-β (Aβ). |
|
| DC12114 |
B I09 |
B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM. |
|
