AZD8529 mesylate| CAS 1314217-69-0|DC Chemicals

Cas No.:	1314217-69-0
Chemical Name:	7-methyl-5-(3-(piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl)-2-(4-(trifluoromethoxy)benzyl)isoindolin-1-one methanesulfonate
Synonyms:	AZD 8529 mesylate;AZD-8529;AZD8529
SMILES:	CC1=CC(=CC2=C1C(=O)N(C2)CC3=CC=C(C=C3)OC(F)(F)F)C4=NC(=NO4)CN5CCNCC5.CS(=O)(=O)O
Formula:	C₂₅H₂₈F₃N₅O₆S
M.Wt:	583.583
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AZD8529 is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes; potentiates agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus and striatum; decreases nicotine self-administration at doses (0.3-3 mg/kg) in monkeys, also reduces nicotine priming- and cue-induced reinstatement of nicotine seeking, decreases nicotine-induced accumbens dopamine release in rats. Schizophrenia Phase 2 Discontinued

References:

References 1. Justinova Z, et al. Biol Psychiatry. 2015 Oct 1;78(7):452-62. 2. Caprioli D, et al. Biol Psychiatry. 2015 Oct 1;78(7):463-73. 3. Li X, et al. Psychopharmacology (Berl). 2016 May;233(10):1801-14. 4. Augier E, et al. Neuropsychopharmacology. 2016 Nov;41(12):2932-2940. View Related Products by Target mGluR Schizophrenia

MSDS

COA

LOT NO.	DOWNLOAD
2018-0101

2018-0101

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AZD-8529 mesylate