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Cat. No. Product name CAS No.
DC20774 VTP 37948

A potent, selective, orally active BACE1 inhibitor for the treatment of Alzheimer's disease..

DC20665 AMG 8718

A potent, selective, orally active BACE1 inhibitor with IC50 of 0.7 nM, demonstrates limited selectivity for over BACE2 and high selectivity both renin and pepsin.

1215868-94-2
DC20324 BRS-3 agonist Compound A

A potent, selective, orally active bombesin receptor subtype-3 (BRS-3) agonist with EC50 of 250/100 nM for human/rat BRS-3, resp+H1437+M1438.

DC20325 BRS-3 agonist Compound A racemate

A potent, selective, orally active bombesin receptor subtype-3 (BRS-3) agonist with EC50 of 270/130 nM for human/rat BRS-3, respectively.

DC21187 JTE907 Featured

A potent, selective, orally active cannabinoid CB2 receptor inverse agonist with Ki of 35.9, 1.55 and 0.38 nM for human, mouse and rat CB2, respectively.

282089-49-0
DC21793 VER-250840

A potent, selective, orally active Chk1 inhibitor with IC50 of < 1 nM, Ki=69 pM.

DC22898 L-365260

A potent, selective, orally active cholecystokinin receptor 2 (CCK2) antagonist with IC50 of 2 nM.

118101-09-0
DC22485 Gefitinib hydrochloride Featured

A potent, selective, orally active EGFR inhibitor with IC50 of 23 nM.

184475-55-6
DC21443 ONO-5334

A potent, selective, orally active inhibitor of cathepsin K with Ki of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively.

868273-90-9
DC23340 CCT-251455

A potent, selective, orally active monopolar spindle 1 (MPS1) inhibitor with IC50 of 3 nM, with no activity for CDK2 and Aurora A (IC50>40 uM).

1400284-80-1
DC25200 PF-1355 Featured

PF-1355 is a potent, selective, orally active Myeloperoxidase (MPO) inhibitor with EC50 of 1.47 uM.

1435467-38-1
DC22900 MLE-4901 Featured

A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia.

941690-55-7
DC22664 Fezolinetant Featured

Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.

1629229-37-3
DC22686 SCH 221510

A potent, selective, orally active nociceptin opioid receptor (NOP) agonist with EC50 of 12 nM, Ki of 0.3 nM.

322473-89-2
DC21276 Seltorexant

A potent, selective, orally active orexin-2 receptor (OX2R) antagonist with pKi of 8.0 and 8.1 for human and rat OX2R, respectively.

1293281-49-8
DC21148 IPI-443

A potent, selective, orally active p110δ/γ PI3K dual inhibitor with cellular IC50 of 0.29 and 7.1 nM, respectively.

DC20681 AS1940477

A potent, selective, orally active p38α/p38β inhibitor with IC50 of 11.2/36.5 nM respectively, with no effect on p38γ and δ isoforms (IC50>1 uM).

928344-12-1
DC23441 CS-0777

A potent, selective, orally active S1P receptor-1 (S1P1) agonist with EC50 of 1.1 nM, 320-fold selectivity over S1P3.

827344-05-8
DC25065 NIBR 0213 Featured

A potent, selective, orally active S1P1 antagonist with IC50 of 2.5 nM Ca2+ mobilization assays, without activity on S1P2, S1P3 and S1P4 (IC50>10 uM).

1233332-14-3
DC21287 MK-4256

A potent, selective, orally active somatostatin receptor SSTR3 antagonist with binding Ki of 0.66 nM, >500-fold selectivity over SSTR1/2/4/5.

1104599-69-0
DC21295 MK-1421

A potent, selective, orally active somatostatin receptor SSTR3 antagonist with binding Ki of 2.3 nM, >2,500-fold selectivity over SSTR1/2/4/5 (IC50>5 uM).

1235995-16-0
DC21579 RO 5073012

A potent, selective, orally active TAAR1 partial agonist with Ki of 6 nM, EC50 of 23 nM (hTAAR1), 140-fold selectivity over β2 adrenergic receptors.

1020814-70-3
DC20654 AM-0902 Featured

A potent, selective, orally active TRPA1 channel antagonist with IC50 of 71 and 131 nM for rTRPA1 and hTRPA1 in Ca2+ flux assays respectively, without agonist activity (EC50>40 uM).

1883711-97-4
DC21179 JNJ 41876666

A potent, selective, orally active TRPM8 channel antaognist with IC50 of 0.8 nM, .

1259026-14-6
DC23198 Adomeglivant

A potent, selective, orally active, small-molecule antagonist of human glucagon receptor with Ki of 6.66 nM.

1488363-78-5
DC22681 E 6130

A potent, selective, orally available CX3C chemokine receptor 1 (CX3CR1) modulator that inhibits the fractalkine-induced chemotaxis of human peripheral blood NK cells with IC50 of 4.9 nM.

1427058-33-0
DC23581 TASP0315003

A potent, selective, orally available GlyT1 inhibitor with IC50 of 1.6 nM, weakly inhibits rat GlyT2 (IC50=138 nM).

1007109-16-1
DC23611 DCCCyB

A potent, selective, orally available GlyT1 inhibitor with IC50 of 29 nM, demonstrates excellent in vivo occupancy of GlyT1 transporters in vivo..

1236046-15-3
DC23599 PF-0346275 Featured

PF-0346275 is a potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM).

1173239-39-8
DC23486 DS-1558

A potent, selective, orally available GPR40 agonist with EC50 of 3.7 nM.

1202575-67-4
DC23300 T-3256336

A potent, selective, orally available IAP antagonist with IC50 of 1.3, 2.2 and 200 nM for cIAP-1, cIAP-2 and XIAP, respectively.

1266227-69-3
DC24182 Nilotinib monohydrochloride monohydrate Featured

A potent, selective, orally available inhibitor of both native and mutant Bcr-Abl with IC50 of 20-80 nM.

923288-90-8
DC23925 Vaniprevir

A potent, selective, orally available inhibitor of HCV NS3/4A protease with Ki of 0.05 and 0.9 nM for GT1b and 2a protease, respectively.

923590-37-8
DC23358 CD 161

A potent, selective, orally bioavailable BET bromodomain inhibitor with IC50 of 7.2 and 28.2 nM for BRD4 BD2 and BRD4 BD1, respectively.

1627716-22-6
DC21177 JNJ 39758979 Featured

JNJ-39758979 is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity.

1046447-90-8
DC24048 NVP-BKM120 hydrochloride Featured

A potent, selective, orally bioavailable inhibitor of class I PI3K isoforms with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively.

1312445-63-8
DC22882 KRH-3955

A potent, selective, orally bioavailable inhibitor of CXCR4 that efficiently inhibits SDF-1α binding to CXCR4 with IC50 of 0.61 nM.

1097732-62-1
DC24065 EPZ-011989 trifluoroacetate

A potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM.

1598383-41-5
DC23552 AS-2444697 HCl Featured

A potent, selective, orally bioavailable IRAK-4 inhibitor that potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1.

1287665-60-4
DC22941 AZD-9056

A potent, selective, orally bioavailable P2X7 receptor antagonist.

345304-65-6
DC21607 SB-649868 Featured

SB-649868 is a potent and selective orally active orexin (OX) 1 and OX2 receptor antagonist (pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).

380899-24-1
DC21598 RWJ-56110

A potent, selective, peptide-mimetic PAR-1 antagonist with binding IC50 of 0.44 uM, with no effect on PAR-2, PAR-3, or PAR-4.

252889-88-6
DC20691 ASP 3652

A potent, selective, peripherally active and orally available FAAH inhibitor for treatment of chronic prostatitis/chronic pelvic pain syndrome..

DC23043 Tpl2-IN-2p

A potent, selective, reversible and ATP-competitive inhibitor of Tpl2 kinase with IC50 of 50 nM.

871307-18-5
DC23933 MK-0893

A potent, selective, reversible and competitive antagonist of glucagon receptor with high binding affinity (IC(=50=6.6 nM) and functional cAMP activity (IC50=15.7 nM).

870823-12-4
DC20412 II-B08

A potent, selective, reversible inhibitor of PTP SHP2 with IC50 of 5.5 uM, exhibits >3-fold selectivity for SHP2 over other PTPs.

1143579-78-5
DC11875 GlpG inhibitor 11

A potent, selective, reversible rhomboid proteases inhibitor with Ki of 45 nM for GlpG .

DC22892 KNT-127

A potent, selectove δ-opioid receptor agonist with Ki of 0.16 nM, dispalys 133.5-fold and 960.5-fold selectivity over μOR and κOR respectively.

1256921-89-7
DC22563 TN1

A potent, small molecule fetal hemoglobin (HbF) inducer with EC50 of 100 nM.

289479-94-3
DC20606 8-Thioquinoline

A potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 2.5 uM..

491-33-8
DC21321 ML349 Featured

A potent, specific acyl protein thioesterase 2 (APT-2, LYPLA2) inhibitor with IC50 of 144 nM and Ki of 120 nM, >20-fold selectivity over APT-1 and serine hydrolase enzyme family.

890819-86-0
DC22529 FPTQ

A potent, specific and allosteric mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1, respectively..

864863-72-9
DC25075 Sivelestat sodium

A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM.

150374-95-1
DC23074 Sivelestat

A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM.

127373-66-4
DC23494 GRI 977143 Featured

A potent, specific and nonlipid agonist of LPA2 receptor with EC50 of 3.3 uM, does not activate any of the other LPA GPCRs (>10 uM).

325850-81-5
DC24105 MK-0591(Quiflapon ) Featured

A potent, specific and orally active 5-Lipoxygenase-activating protein (FLAP) inhibitor with IC50 of 1.6 nM in FLAP binding assay.

136668-42-3
DC11556 trans-AUCB

A potent, specific and orally bioavailable soluble epoxide hydrolase (sEH) inhibitor with IC50 of 1.3 nM.

885012-33-9
DC21802 VU 0364849

A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM.

1206711-14-9
DC21807 VU 0465350 Featured

VU 0465350 is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM; shows no activity for ALK2/4/5, also shows affinity for TGFBR2, VEGFR2 and AMPK; blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy.

1414843-61-0
DC21693 SRI-29329

A potent, specific CDC-like kinase (CLK) inhibitor with IC50 of 78, 16 and 86 nM for CLK1, 2 and4, respectively.

2086809-58-5
DC21794 VH 298 Featured

A potent, specific cell-active VHL E3 ubiquitin ligase inhibitor that inhibits VHL/HIF-α interaction with Kd of 90 nM in ITC assays.

2097381-85-4
DC23985 CHIR-99021 trihydrochloride

A potent, specific GSK-3 inhibitor with IC50 of 5 nM and 10 nM for GSK3β and GSK3α, respectively.

1782235-14-6
DC21150 PR-924

A potent, specific immunoproteasome LMP7 subunit inhibitor with IC50 of 25 nM, >100-fold selectivity over β5c, β1i, β1c, β2i and β2c subunits (IC50>3 uM).

1416709-79-9
DC21773 UK-101

A potent, specific immunoproteasome β1i (LMP2) subunit inhibitor with IC50 of 104 nM, 144- and 10-fold selectivity over β1c and β5 subunit respectivey.

1000313-40-5
DC21527 PR-893

A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 17 nM, 21-fold and 13-fold selectivity for β5 over LMP7 and LMP2 subunits, respecitvely..

1426305-23-8
DC21365 NC-005

A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely.

1237540-74-7
DC21528 PR-825

A potent, specific immunoproteasome β5 subunit inhibitor..

935888-08-7
DC24007 R-1479 Featured

A potent, specific inhibitor of HCV NS5B polymerase and HCV replication (IC50=1.28 uM, replicon assay).

478182-28-4
DC22758 SI-113

A potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells.

1392816-46-4
DC20998 ES 936

A potent, specific mechanism-based human NAD(P)H: quinone oxidoreductase 1 (NQO1) inhibitor that demonstrates efficient inactivation of NQO1 at 100 nM in in cellular systems.

192820-78-3
DC22823 Tariquidar methanesulfonate hydrate

A potent, specific P-gp inhibitor with Kd of 5.1 nM.

625375-83-9
DC21849 YU-101

A potent, specific proteasome β5 subunit inhibitor with IC50 of 0.26 uM, 7.3 and 17.3-fold selectivity over β2i and β1i subunit, respecitvely..

254888-42-1
DC26068 BMS-753

A potent, specific RARα agonist with Ki of 2 nM, displays no significant effects on RARγ in reporter based assays..

215307-86-1
DC22661 AB1

A potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 3 nM, with no agonistic or antagonistic activities on other S1PRs.

1463912-49-3
DC24060 YM-155 hydrochloride Featured

A potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM.

355406-09-6
DC22864 KSP-IA

A potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM.

639074-49-0
DC22865 CK-0106023 Featured

A potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM.

336115-72-1
DC21318 ML 171

A potent, specific, cell-active NADPH oxidase1 (Nox1) inhibitor that strongly blocks ROS generation in HT29 cells with IC50 of 0.129 uM.

6631-94-3
DC20890 ChoK-α inhibitor CK37 Featured

A potent, specific, competitive inhibitor of choline kinase-α (Chok-α) by targeting the choline binding site; significantly increases LC3II expression in MCF-7 and MCF-7/TAM cells, increases the size and number of autophagosome, causes MCF-7 and MCF-7/TAM

1001478-90-5
DC21110 HCI-2389

A potent, specific, irreversible NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 16.65 nM.

DC26079 GW 803430 Featured

A potent, specific, orally active melanin concentrating hormone receptor 1 (MCHR1) inhibitor with kI of 3.8 nM, >100-fold selectivity over a battery of GPCRs, ion channels and enzymes.

515141-51-2
DC20928 CRT0066101 Featured

A potent, specific, orally active pan-PKD (protein kinase D) inhibitor with biochemical IC50 of 1, 2.5 and 2 nM for PKD1, 2, and 3 respectively.

1883545-60-5
DC22550 TAK-220

A potent, specific, orally bioavailable CCR5 antagonist that blocks the binding of MIP-1α to CCR5 with IC50 of 1.4 nM.

333994-00-6
DC22540 Pasireotide Featured

Pasireotide (SOM230), a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide also exhibits antisecretory, antiproliferative, and proapoptotic activity. At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Pasireotide acetate) usually boasts enhanced water solubility and stability.

396091-73-9
DC22539 Pasireotide L-aspartate salt

A potent, stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (pKi=8.2/9.0/9.1/<7.0/9.9 for sst1/2/3/4/5, respectively).

396091-77-3
DC22746 TROX-1

A potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM, compared with hyperpolarized conditions (IC50>20 uM).

1309601-26-0
DC23782 4-Br-BnIm

A potent, subtype-selective Grp94 inhibitor with Kd of 0.96 uM, 13-fold selectivity over Hsp90α.

1654775-71-9
DC23519 PF-06462894

A potent, subtype-selective mGluR5 negative allosteric modulator with Ki of 6.1 nM.

1622291-66-0
DC22939 NS3861 fumarate Featured

NS3861 fumarate is an agonist of nicotinic acetylcholine receptors (nAChRs) and binds with high affinity to heteromeric α3β4 nAChR. The binding Ki values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively.

216853-60-0
DC22923 HXJ 42

A PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70, as assessed by Erk and Lat phosphorylation, as well as by proliferative responses of mature CD4+ cells.

1428640-39-4
DC22471 Pantoprazole sodium hydrate

A proton pump inhibitor that inhibits gastric acid secretion.

164579-32-2
DC23928 Esomeprazole magnesium salt

A proton pump inhibitor that reduces stomach acid secretion by inhibition of the H+/K+-ATPase in the parietal cells.

1198768-91-0
DC25089 Esomeprazole agnesium trihydrate

A proton pump inhibitor that reduces stomach acid secretion by inhibition of the H+/K+-ATPase in the parietal cells.

217087-09-7
DC24176 Esomeprazole potassium salt

A proton pump inhibitor that reduces stomach acid secretion by inhibition of the H+/K+-ATPase in the parietal cells.

161796-84-5
DC23938 Esomeprazole sodium Featured

A proton pump inhibitor that reduces stomach acid secretion by inhibition of the H+/K+-ATPase in the parietal cells.

161796-78-7
DC23004 PSMA-ligand-1 Featured

A PSMA (prostate-​specific membrane antigen) ligand-​tubulysin compound..

1610413-97-2
DC20605 Enexasogaol

A pungent agent isolated from Zingiber officinale Roscoe, has been known to have anti-tumor and anti-inflammatory effects.

23513-13-5
DC22348 Zalcitabine Featured

A pyrimidine analog reverse transcriptase inhibitor (NRTI) for the treatment of HIV/AIDS.

7481-89-2
DC22388 Mefloquine hydrochloride

A quinoline antimalarial drug that is structurally related to the antiarrhythmic agent quinidine.

51773-92-3
DC21407 AG-1295

A quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGFR kinase in vitro and in Swiss 3T3 cells with IC50 of 0.3-1 uM.

71897-07-9
DC23472 TASP0434299

A radioligand candidate for arginine vasopressin 1B (V1B) receptor that exhibits high binding affinities for human and rat V1B receptors with IC50 of 0.526 and 0.641 nM, respectively.

1520893-08-6
DC26104 UVI 2008

A RARβ/γ agonist originated from TTNPB, is also a selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10) with IC50 of 6.1 uM.

1504556-86-8
DC22985 BMS-948

A RARβ-selective agonist that exhibits a full transcriptional agonistic activity and activating RARβ as efficiently as the reference agonist TTNPB.

168901-49-3
DC7350 9-methyladenine

A receptor adenine derivative binding membrane brain animal cell line.For the detailed information of 9-methyladenine, the solubility of 9-methyladenine in water, the solubility of 9-methyladenine in DMSO, the solubility of 9-methyladenine in PBS buffer, the animal experiment (test) of 9-methyladenine, the cell expriment (test) of 9-methyladenine, the in vivo, in vitro and clinical trial test of 9-methyladenine, the EC50, IC50,and Affinity of 9-methyladenine, Please contact DC Chemicals..

700-00-5
DC23842 L-783277

A resorcylic lactone type covalent kinase inhibitor that inhibits ALK1 with IC50 of 125 nM, also inhibits FLT3, VEGFR2, VEGFR3, MEK2 with IC50 of 1-10 nM..

791807-02-8
DC24096 Dabigatran ethyl ester

A reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.

429658-95-7
DC22367 Bromethalin

A rodenticide that poisons the central nervous system by uncoupling mitochondrial oxidative phosphorylation, which causes a decrease in adenosine triphosphate (ATP) synthesis..

63333-35-7
DC21011 KP-1019 sodium salt

A ruthenium complex anticancer agent that is useful for metastatic tumors and cis-platin resistant tumors.

DC20822 BMT-052

A second generation, orally biovailable pan-genotypic HCV NS5B polymerase inhibitor with EC50 of 1-10 nM.

1628720-84-2
DC24180 Cetirizine

A second-generation antihistamine that acts as a selective H1 receptor antagonist.

83881-51-0
DC22589 Eltanexor

A second-generation SINE, orally bioavailable Exportin 1 (XPO1,CRM1) inhibitor with markedly reduced brain penetration compared to selinexor (30-fold less).

1642300-52-4
DC23944 K-7174 Featured

A selctive small molecule inhibitor of the transcription factor GATA-binding protein 2 (GATA2).

191089-59-5
DC23943 K-7174 dihydrochloride Featured

K-7174 dihydrochloride is a selctive small molecule inhibitor of the transcription factor GATA-binding protein 2 (GATA2).

191089-60-8
DC20568 Tec Kinase-IN-6

A selecitve small molecule toward Tec kinase-mediated tyrosine phosphorylation of FGF2 with IC50 of 8.9 uM.

923762-87-2
DC23996 Capadenoson Featured

Capadenoson is a selective agonist of adenosine-A1 receptor.

544417-40-5
DC22954 MG-624 Featured

MG624 is a potent and selective neuronal α7 nAChR antagonist with a Ki of 106 nM.

77257-42-2
DC21853 Ogerin Featured

A selective GPR68 positive allosteric modulator (pEC50=6.83) with minimal PAM activity at the related proton-sensing GPCRs GPR4 and GPR65.

1309198-71-7
DC20596 O-phenanthroline

A selective inhibitor of 26S proteasome subunit Rpn11 with IC50 of 10±2 uM.

66-71-7
DC22980 ND-336

A selective inhibitor of the gelatinases MMP2 and MMP9 and MMP13 with Ki of 85, 150 and 120 nM, respectively.

1807453-83-3
DC21127 HT-0411

A selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 1.4 uM, with less potency for MT-1 and MT-2.

947539-81-3
DC23235 Flupirtine

A selective neuronal potassium channel (KCNQ/KV7 channel) activator that also has indirect NMDA receptor antagonist and GABAA receptor modulatory properties.

56995-20-1
DC26069 SR-11237 Featured

SR-11237 is a selective pan retinoid X receptor (RXR) agonist with no retinoid A receptor (RAR) activity. .

146670-40-8
DC22616 CJ-42794 Featured

A selective prostaglandin E receptor subtype 4 (EP4) antagonist with pKi of 8.5.

847728-01-2
DC20567 Tec Kinase-IN-21

A selective small molecule toward Tec kinase-mediated tyrosine phosphorylation of FGF2 with IC50 of 11.7 uM.

931664-41-4
DC20566 Tec Kinase-IN-14

A selective small molecule toward Tec kinase-mediated tyrosine phosphorylation of FGF2 with IC50 of 7.0 uM.

852838-07-4
DC25014 Cysmethynil

A selective small-molecule inhibitor of tisoprenylcysteine carboxyl methyltransferase (Icmt) with IC50 <200 nM, does not inhibit other enzymes (farensyltransferase, geranylgeranyltransferase type I, and Rce1) at concentrations up to 50 uM.

851636-83-4
DC22924 3M-002

A selective TLR8 agonist that induces activation of NF-κB at 0.4 uM.

256922-53-9
DC20306 AMTB hydrochloride Featured

A selective TRPM8 channel blocker with pEC50 of 6.91 in Ca(2+) influx assay, with no activity for TRPV4 (pEC50<4.6).

926023-82-7
DC23226 Guanfacine

A selective α2A receptor agonist that can reduce peripheral sympathetic outflow and thus cansues a reduction in peripheral sympathetic tone.

29110-47-2
DC24156 Metoprolol

A selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension..

51384-51-1
DC7029 SC-26196 Featured

A selective Δ6 desaturase inhibitor that displays selectivity over Δ5 and Δ9 desaturases

218136-59-5
DC26107 TRV0109101 hydrochloride

A selective, G protein-biased µ-opioid receptor agonist, does not promote the development of opioid-induced mechanical allodynia (OIMA) and rapidly reverses allodynia in vivo..

2101210-22-2
DC26103 TRV0109101

A selective, G protein-biased µ-opioid receptor agonist, does not promote the development of opioid-induced mechanical allodynia (OIMA) and rapidly reverses allodynia in vivo..

1401027-29-9
DC21728 TAK-070

A selective, nonpeptidic, noncompetitive BACE1 inhibitor with IC50 of 3.15 uM in cell-free assays.

365276-12-6
DC20995 EP009

A selective, orally active JAK3 inhibitor that reduces IL-2-mediated JAK3 tyrosine phosphorylation with cellular IC50 of 10-20 uM.

1462951-30-9
DC20287 δ-secretase inhibitor 11

A selective, orally bioactive and brain permeable δ-secretase (AEP.

842964-18-5
DC22971 CDE 096

A selective, reversible, high-affinity PAI-1 inhibitor that prevents PAI-1 from inactivating tPA and uPA with similar potency (IC50=30 and 25 nM, respectively).

1228357-04-7
DC21780 UNC-3230

A selective, small molecule inhibitor of PIP5K1C with IC50 of 41 nM, does not ihibits other lipid kinases including PI3Ks.

1031602-63-7
DC21400 NS-1209

A selective, water-soluble, in vivo long-lasting AMPA antagonist with Ki of 43 nM.

245063-59-6
DC22451 AQX 1125 acetate

A sepecific, orally bioavailable SHIP1 activator with no effect on functional androgen, oestrogen, oestrogen-related receptor α, glucocorticoid, mineralocorticoid and progesterone receptor at 30 uM.

782487-29-0
DC23981 BCX-1470 methanesulfonate Featured

A serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM).

217099-44-0
DC22666 Levosalbutamol

A short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD)..

34391-04-3
DC23231 Levalbuterol tartrate

A short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD)..

661464-94-4
DC22828 DBCO-Amine

A simple DBCO-containing building block used to derivatize carboxyl groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) with DBCO moiety through a stable amide bond.

1255942-06-3
DC23011 Shz-1

A small cardiogenic molecule that potently induces Nkx2.5 and a subset of other cardiac markers, including myocardin, troponin-I, and sarcomeric α-tropomyosin (SαTM) in a variety of different stem/progenitor cells.

326886-05-9
DC25018 Shz-3

A small cardiogenic molecule that potently induces Nkx2.5 and a subset of other cardiac markers, including myocardin, troponin-I, and sarcomeric α-tropomyosin (SαTM) in a variety of different stem/progenitor cells.

1033831-23-0
DC21818 MIN-117

A small molecule 5-HT1A and 5-HT2A receptor antagonist and inhibitor of serotonin and dopamine reuptake, also possess affinity for the α1A- and α1B-adrenergic receptors..

310392-93-9
DC22831 VU 0038882

A small molecule activator of S. aureus HssRS (heme sensor system) that induces endogenous heme biosynthesis by perturbing central metabolism.

429653-28-1
DC23648 TKN2

A small molecule allosteric inhibitor of TREK channels with IC50 of 3.8, 1.7 and 10.3 uM for TREK-1, TREK-2 and TRAAK, respectively..

886636-57-3
DC23585 28NH

A small molecule allosteric inhibitor of TREK channels with IC50 of 5.0, 5.0 and 11.8 uM for TREK-1, TREK-2 and TRAAK, respectively..

1082816-22-5
DC23582 TKN1

A small molecule allosteric inhibitor of TREK channels with IC50 of 6.5, 4.4 and 15.7 uM for TREK-1, TREK-2 and TRAAK, respectively..

432533-28-3
DC23241 TAME

A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1).

901-47-3
DC11655 ABO dihydrochloride

A small molecule ANXA7 GTPase activity inhibitor, induces mouse ESCs differentiation to VECs.

896126-03-7
DC24017 SMER-18

A small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein.

944153-47-3
DC23190 LM22A-4

A small molecule BDNF mimetic that act as a direct and specific partial agonist of TrkB (EC50=200-500 pM), but not p75.

37988-18-4
DC25021 Endosidin-2 Featured

A small molecule binds to the EXO70 (exocyst component of 70 kDa) subunit of the exocyst complex (Kd=253 uM), resulting in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking..

1839524-44-5
DC22842 DMJ-I-228

A small molecule CD4-mimetic that binds gp120 and blocks CD4 binding, inhibits HIV-1 entry with IC50 of 86.9 uM..

1374035-59-2
DC22524 ZSET1446

A small molecule cognitive enhancer that potentiates acetylcholine-mediated facilitation of inhibitory synaptic transmission in the hippocampal neurons.

887603-94-3
DC20445 Me6TREN

A small molecule Cu complexing ligand used for atom transfer radical polymerization (ATRP).

33527-91-2
DC21067 TB-03

A small molecule Grb2 SH2 domain binding antagonist that synergistically enhances inhibition of K562 leukemia cell proliferation by imatinib (CI=0.774).

491831-49-3
DC22843 DDX3-IN-16d Featured

A small molecule inhibitor (IC50=0.3 uM) of DEAD-box polypeptide 3 (DDX3), a human host factor required for the replication of several DNA and RNA viruses.

1919828-83-3
DC23010 R-59949(R-59-949) Featured

A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets.

120166-69-0
DC23017 R 59022 Featured

A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 2.8 uM, inhibits the phosphorylation of OAG to OAPA with IC50 of 3.8 uM in intact platelets.

93076-89-2
DC24022 NSC-305787 hydrochloride

A small molecule inhibitor of Ezrin with Kd of 5.85 uM.

53868-26-1
DC23826 UC-857993

A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction.

487001-04-7
DC23810 UC-773587

A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction.

116679-69-7
DC25040 Heclin

A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively.

890605-54-6
DC22838 SCH 351125

A small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor.

370893-06-4
DC25031 C2-8

A small molecule inhibitor of polyglutamine (polyQ) aggregation in Huntington's disease neurons.

300670-16-0
DC22761 NCI-83633 Featured

A small molecule inhibitor of PP2C that activates extensive 3' cleavage at a concentration 50-fold below that required by fluoride or CP..

732-85-4
DC22552 IC-87201 Featured

A small molecule inhibitor of PSD-95/nNOS interaction with IC50 of 31 uM, without inhibiting nNOS catalytic activity.

866927-10-8
DC20360 DIDS

A small molecule inhibitor of RAD51-mediated homologous recombination.

304655-84-3
DC25034 Lin28-IN-1632

A small molecule inhibitor of RNA binding protein Lin28 that blocks the Lin28/let-7 interaction, rescues let-7 processing and function in Lin28-expressing cancer cells.

108825-65-6
DC23774 MS-444

A small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 7 nM.

150045-18-4
DC23773 Okicenone

A small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 90 nM.

137018-54-3
DC22852 Sortase-IN-6e

A small molecule inhibitor of Staphylococcus aureus sortase with IC50 of 9.3 uM.

1809545-62-7
DC22984 IT-603 Featured

A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays.

292168-90-2
DC22833 KKL-35 Featured

A small molecule inhibitor of trans-translation that has broad-spectrum antibiotic activity.

865285-29-6
DC21166 JK-273

A small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin.

187723-38-2
DC22832 Filastatin Featured

Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect.

431996-53-1
DC23982 Navoximod (GDC-0919; NLG-​919) Featured

Navoximod (GDC-0919; NLG-​919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.

1402837-78-8
DC21415 Ferristatin II

A small molecule iron transport inhibitor that promotes degradation of transferrin receptor-1 in vitro and in vivo, through a nystatin-sensitive lipid raft pathway.

1937-37-7
DC23314 UNC-2170 maleate

A small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain.

2173992-60-2
DC20453 MitoBloCK 6

A small molecule mitochondrial protein import blocker that inhibits Erv1 oxidase activity.

303215-67-0
DC21795 VJ115

A small molecule NADH oxidase ENOX1 inhibitor with IC50 of 10 uM.

929256-79-1
DC23762 PDI inhibitor 16F16 Featured

PDI inhibitor 16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.

922507-80-0
DC21395 NPD926

A small molecule ROS inducer that induces rapid cell death in cancer cells, induces reactive oxygen species via cellular glutathione depletion.

384361-79-9
DC23505 JVW-1009

A small molecule sigma receptor ligand with Ki of 96 and 70 nM for sigma 1 and sigma 2, respectively.

2089059-30-1
DC23210 SZL P1-41 Featured

A small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro.

222716-34-9
DC20527 Ractopamine Featured

A small molecule TAAR1 agonist and β adrenoreceptor agonist that stimulates β1 and β2 adrenergic receptors.

97825-25-7
DC21557 RB-011

A small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells.

1425049-26-8
DC25050 LCL204

A small molecule that inhibits N-myristoyltransferase (NMT1) with IC50 of 8.7 uM, 10-fold enhanced inhibitory potency than LCL4.

366487-89-0
DC21123 NSC624548

A small molecule that inhibits the activities of E. coli DNA polymerase I and calf thymus DNA polymerase alpha..

105128-93-6
DC21418 NSC 243928 Featured

NSC243928(NSC-243928 ) is a small molecule that potently inhibit ovarian cancer stem-like cells (CSC) growth with GI50 of 0.83 uM, which os consistent with cell death/apoptosis..

59988-01-1
DC22777 FPH 2(BRD9424) Featured

A small molecule that promotes differentiation of iPS-derived hepatocytes.

957485-64-2
DC20356 DFPM

A small molecule that rapidly downregulates abscisic acid (ABA)-dependent gene expression (IC50=3 and 1.5 uM for RD29B and RAB18 promoters), also inhibits ABA-induced stomatal closure.

301338-95-4
DC25025 Compound A5

A small molecule that specifically inhibits the clathrin adaptor complex AP-1-dependent traffic, does not significantly affect other pathways through the trans-Golgi network (TGN).

938071-78-4
DC22839 TCA-1

A small molecule with activity against drug-resistant and persistent tuberculosis.

864941-32-2
DC20387 Galiellalactone

A small molecule, direct STAT3 inhibitor that inhibits the IL-6-induced SEAP expression with IC50 of 200-500 nM, blocks the binding of the activated STAT3 dimers to DNA.

133613-71-5
DC22841 NBD-11021

A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction.

1427304-84-4
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