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Cat. No.	Product Name	Field of Application
DC21314	ML316 Featured	ML316 is a specific antifungal agent that fungal-selectively inhibits the mitochondrial phosphate carrier Mir1, exhibits potent antifungal activity against the moderatelyazole-resistant C. albicans strain CaCi-2 with MIC of 0.05 ug/ml.
DC26087	ML350	ML350 (CYM 50202) is a highly potent and selective Opioid kappa receptor (OPRK1/KOR) antagonist with IC50 of 9-16 nM.
DC21809	ML352	ML352 (VU-0476201) is a potent, selective choline transporter (CHT) inhibitor with Ki of 92 nM.
DC21804	ML354 Featured	ML354 (VU0099704) is a novel potent and selective PAR4 antagonist with IC50 of 140 nM, displays 71-fold selectivity versus PAR-1.
DC21315	ML358	ML358 is a first in class, selective small molecule inhibitor of the SKN-1 pathway with IC50 of 0.24 uM.
DC23760	ML359 Featured	ML359 is a small molecule, specific inhibitor of Protein disulfide isomerase (PDI) with IC50 of 250 nM; displays >100-fold selectivity over other thiol isomerases (Erp5, Thioredoxin, Thioredoxin reductase); shows no cytotoxicity in three human cell lines, and some activity in inhibiting platelet aggregation in vitro.
DC21688	ML368	ML368 (SR 9186) is a potent, selective cytochrome P450 enzyme CYP3A4 inhibitor with IC50 of 4 nM (convert testosterone to hydroxytestosterone), displays >2,000-fold selectivity over CYP3A5..
DC23748	ML372 Featured	ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM; possesses good potency, pharmacokinetics, tolerance, and CNS penetration that are able to increase levels of SMN protein in several model cell lines; increase SMN protein levels in vivo, restore motor function, and prolong survival of SMNΔ7 SMA Mice; improves the righting reflex and extended survival of a severe mouse model of SMA.
DC23445	ML375	ML375 (VU-0483253) is a potent, highly selective M5 NAM with submicromolar potency (human M5 IC50=300 nM, rat M5 IC50=790 nM, M1-M4 IC50> 30 uM), exhibts excellent multispecies PK, high CNS penetration, and enantiospecific inhibition..
DC21327	ML377	ML377 (MLS 0472732) is a small molecule probe that selectively inhibits TAG (Triacylglyceride) accumulation with an IC50 of 1.1 uM, show >45-fold selectivity versus DGAT inhibition and cytotoxicity..
DC20901	ML378	ML378 (CID71710938, JJH-254) is an in vivo active carbamate-based dual inhibitor of lysophospholipase LYPLA1 (APT1) and LYPLA2 (APT2) with IC50 of 122 nM and 245 nM, repectively.
DC23285	ML379	ML379 (CID71576758) is a potent, selective TP53 mutant cancer cells inhibitor with IC50 of 13 nM in sensitive HeLa cells (TP53 mutant).
DC23512	ML381 (VU0488130) Featured	ML381 (VU0488130) is a highly mAChR subtype selective M5 orthosteric antagonist with IC50/Ki of 450/340 nM for hM5, has no inhibitory activity on hM1-4 (IC50>30 uM).
DC20900	ML382 Featured	ML382 is a potent, selective, positive allosteric modulator of Mas-related G protein-coupled receptor X1 (MrgprX1) with EC50 of 190 nM in cell based Ca2+ imaging assay.
DC20897	ML387	ML387 (CID3474778) is a potent, selective NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD) inhibitor with IC50 of 19 nM.
DC20899	ML388	ML388 is a potent, selective NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD) inhibitor with IC50 of 34 nM.
DC23446	ML389	ML389 is a highly potent, selective vasopressin receptor 1a (V1a-R) antagonist with IC50 of 40 nM.
DC21808	ML395	ML395 is a potent, selective, allosteric phospholipase D2 (PLD2) inhibitor with cellular IC50 of 360 nM, shows >80-fold selectivity over PLD1 (IC50>30 uM).
DC23488	ML398	ML398 (CID72737723) is a potent, selective, highly brain penetrant dopamine 4 (D4) receptor antagonist with IC50/Ki of 130 nM/60 nM.
DC21810	ML399	ML399 (VU0516340) is a potent and cell penetrant menin-MLL inhibitor with IC50 of 90 nM.
DC20903	ML401 (CID73169083) Featured	ML401 (CID73169083) is a potent, functional antagonist of EBI-2 (Epstein-Barr virus-induced gene 2) with IC50 of 1 nM, displays activity in a chemotaxis assay (IC50=6 nM).
DC20902	ML404	ML404 is a small molecule inhibitor of mtPTP, inhibits mitochondrial swelling with EC50 of 4.9 nM, shows no effect on mitochondrial coupling at >100 uM.
DC20456	ML-406 Featured	ML406 is a small molecule Mtb bioA (DAPA synthase) enzyme inhibitor (IC50=30 nM) that shows anti-tubercular activity, dispalys >100-fold selectivity over bioD.
DC21322	ML-60218 Featured	ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively.
DC2052	ML-7 Hydrochloride Featured	ML-7 Hydrochloride is a selective inhibitor of myosin light chain kinase (MLCK) (Ki = 0.3 μM).
DC20457	ML-9 hydrochloride Featured	ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation.
DC22158	MLAF50	MLAF50 is the first small-molecule inhibitor of the REV1 UBM2-Ubiquitin interaction, directly binds to REV1 UBM2 with Kd of 37 uM in SPR assays.
DC23469	MLN 3897	MLN 3897 is a potent, specific and orally active antagonist of CCR1 with IC50 of 0.8 nM in competition binding assays, 500-fold selectivity over CCR5.
DC7469	MLN0905	MLN0905 is a mall-molecule and potent inhibitor of PLK1 with IC50 of 2 nM.
DC7198	MLN-120B Featured	MLN120B is a potent and effective IKKbeta inhibitor.

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