| DC37800 |
7-Hydroxymethotrexate |
7-Hydroxymethotrexate is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases. Elimination of 7-hydroxy MTX is associated with the multi-drug transporters Abcc2, Abcc3, and Abcg2 in transgenic mouse models. It and the parent compound rapidly accumulate when all three transporters are absent.2 Formulations containing methotrexate have been used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. Various methods have been described to quantify 7-hydroxy MTX levels during cancer therapy to avoid toxicity. |
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| DC37801 |
Folcysteine |
Folcysteine is a cysteine derivative with potential antitumor agent, a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. |
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| DC37802 |
Methotrexate 1-methyl ester |
Methotrexate 1-methyl ester is an impurity of Methotrexate, a folic acid antagonist. Used as a antineoplastic and antirheumatic. |
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| DC37803 |
Methotrexate 5-methyl ester |
Methotrexate 5-methyl ester is an impurity of Methotrexate, a folic acid antagonist. Used as a antineoplastic and antirheumatic. |
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| DC37805 |
LY-338979 |
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| DC37806 |
L-Saccharopine |
L-Saccharopine is a product of breakdown of essential amino acid Lysine. Saccharopine is also part of the α-aminoadipate pathway of fungal lysine biosynthesis. |
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| DC37807 |
N-Benzoyl-L-glutamic acid |
N-Benzoyl-L-glutamic acid is an amino acid. |
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| DC37808 |
Glutamyl-glutamic acid |
Glutamyl-glutamic acid is an α-amino acid. |
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| DC37809 |
Aceglutamide |
Aceglutamide is a psychostimulant, nootropic, and antiulcer agent that is marketed in Spain and Japan. It is an acetylated form of the amino acid L-glutamine, the precursor of glutamate in the body and brain. Aceglutamide functions as a prodrug to glutamine with improved potency and stability. Aceglutamide is used as a psychostimulant and nootropic, while aceglutamide aluminum is used in the treatment of ulcers. Aceglutamide can also be used as a liquid-stable source of glutamine to prevent damage from protein energy malnutrition. The drug has shown neuroprotective effects in an animal model of cerebral ischemia. |
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| DC37810 |
Phenylacetylglutamine |
Phenylacetylglutamine is used as biomarker for metabolic age. |
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| DC37811 |
Alanylglutamine |
Alanylglutamine is used in cell culture as alternative delivery forms of stabilized L-glutamine. The primary advantage of using L-alanylglutamine in place of L-glutamine is that it reduces the level of ammonia generated during cell culture. |
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| DC37812 |
n-Hexyl acetate |
n-Hexyl acetate is an ester. It is mainly used as a solvent for resins, polymers, fats and oils. It is also used as a paint additive to improve its dispersion on a surface.
n-Hexyl acetate is also used as a flavoring because of its fruity odor, and it is naturally present in many fruits (such as apples and plums) as well as alcoholic beverages. |
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| DC37813 |
Diglycyl-histidine |
Diglycyl-histidine is a tripeptide complexed with cupric ion designed to mimic specific Cu(II) transport site of ascorbate on albumin molecule; glycylglycylhistamine is An amine derived by enzymatic decarboxylation of histidine. |
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| DC37814 |
Pyroglutamylhistidine |
Pyroglutamylhistidine is a dipeptide. |
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| DC37815 |
Homoarginine |
Homoarginine is an amino acid. |
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| DC37816 |
S-Adenosyl-L-homocysteine |
S-Adenosylhomocysteine is an amino acid derivative used in several metabolic pathways in most organisms. It is an intermediate in the synthesis of cysteine and adenosine. |
|
| DC37817 |
O-Succinylhomoserine |
O-Succinylhomoserine is an intermediate in the formation of cystathionine, and consequently of methionine by E. coli. |
|
| DC37818 |
Hyprolose |
Hyprolose is a derivative of cellulose with both water solubility and organic solubility. It is used as an excipient, and topical ophthalmic protectant and lubricant. |
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| DC37819 |
Hyoscyamine hydrobromide |
Hyoscyamine hydrobromide is an anticholinergic. |
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| DC37820 |
L-6-Hydroxydopa |
Levadopa Related Compound A is the 6-hydroxy derivative of the amino acid L-DOPA with neurotoxic properties. Studies show that exogenously administered 6-Hydroxy-L-DOPA is biotransformed by amino acid decarboxylase to the highly potent and catecholamine-selective neurotoxin, 6-Hydroxydopamine. The treatment of 6-Hydroxy-L-DOPA in rats resulted in the stimulation of acetylcholinesterase. |
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| DC37821 |
Iditol |
Iditol is a rare sugar alcohol (polyol). |
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| DC37822 |
(-)-Isopinocampheol |
(-)-Isopinocampheol is a monoterpene and a component of several plant essential oils, showed dual viricidal activity against herpes simplex virus 1 (HSV-1). |
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| DC37823 |
Prolylisoleucine |
Prolylisoleucine is a derivative of isoleucine, an α-amino acid that is used in the biosynthesis of proteins. |
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| DC37824 |
(-)-Isoproterenol tartrate |
Isoproterenol tartrate, (-)- is a β-Adrenoceptor agonist; increases cytosolic cAMP. |
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| DC37825 |
Ethyl L-isoleucinate hydrochloride |
L-Isoleucine ethyl ester HCl is a bioactive chemical. |
|
| DC37826 |
L-Kynurenine |
L-Kynurenine is a key intermediate in the breakdown of L-tryptophan and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway. It is involved in a variety of neurological processes and diseases. L-Kynurenine is a substrate for kynureninase/kynurenine hydrolase; kynurenine 3-monooxygenase and kynurenine-oxoglutarate transaminase. |
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| DC37827 |
Leucyl-leucyl-tyrosine |
Leucyl-leucyl-tyrosine is a bioactive chemical. |
|
| DC37828 |
N-Benzyloxycarbonylserylleucinamide |
N-Benzyloxycarbonylserylleucinamide is a bioactive chemical. |
|
| DC37829 |
Ici 216140 |
ICI 216140 is a GRP/bombesin receptor 2 antagonist (IC50 = 2 nM in vitro). At 2 mg/kg, it can reduce bombesin-stimulated pancreatic amylase secretion in rats. At 1 mM, it has been shown to attenuate bombesin-stimulated increases in blood pressure in rats.
Bombesin is a peptide, originally isolated from the skin of the European fire-bellied toad, with pressor and sympathoexcitatory activity. Its three receptors are distributed throughout the central and peripheral nervous system and are involved in gastric acid secretion, emotional response, temperature control, learning, and memory. Neuromedin B and gastrin-releasing peptide (GRP) are mammalian homologs of bombesin. |
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| DC37830 |
gamma-Methylleucine |
gamma-Methylleucine is an auxiliary for copper-catalyzed asymmetric Michael reactions. |
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