| DC74556 |
JKF-034 |
JKF-034 is an effective,blood-brain barrier (BBB) permeable small molecule inhibitor of hippocampal Rac1 activity, rescues learning deficits in APP/PS1 mice. |
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| DC74557 |
PREX-in1
Featured
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PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic DH domain. |
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| DC74558 |
BAY 2686013 |
BAY 2686013 is a selective, allosteric antagonist of human pituitary adenylate cyclase activating polypeptide receptor (hPAC1-R) with IC50 of 0.92 and 0.4 uM in cAMP HTRF and Ca2+ release assays, respectively. |
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| DC74559 |
PA-915 |
PA-915 (PA915) is a small-molecule, non-peptide antagonist of the PACAP type I (PAC1) receptor, inhibits PACAP (1 nM)-induced phosphorylation of CREB in PAC1/CHO cells with IC50 of <10 pM. |
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| DC74560 |
Ro 25-1553 |
Ro 25-1553 is a potent, selective VIPR2 agonist and a cyclic peptide analog of vasoactive intestinal peptide (VIP), displaces the radioligand 125I-VIP from rat forebrain membranes with IC50 of 4.98 nM. |
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| DC74229 |
Zenuzolac |
Zenuzolac (GLS1027, VGX-1027) is a small molecule immunosuppressant and an orally available isoxazole compound, inhibits toll-like receptor 4 (TLR4) activity, has shown promise for the treatment of several neuroinflammatory disorders. |
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