IRES-J007 ia an improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.

An impurity of Roflumilast, which is a selective and long-acting inhibitor of PDE-4 with IC50 value of 0.8 nM..

An indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells, directly inhibits Src kinase activity (IC50=0.43 uM) in vitro.

An inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM.

An inhibitor of aldose reductase with IC50 of 28.9 pM.

An inhibitor of histone demethylase..

An inhibitor of the IMP-selective cytosolic 5'-nucleotidase (IC50=2-6 mM).

An insecticide agent that is approved for application on high-value crops such as grapes, tomatoes and other vegetables..

An insecticide agent..

An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells.

An irreversible local anesthetic.

An irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively.

PK 11195 is a ligand of translocator protein. It targets Leishmania chemotherapy (IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively).

An non-competitive, allosteric inhibitor of PTP1B with Ki of 0.6 uM for PTP1B1-405.

Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1.

An oral glucocorticoid agonist for the treatment of rheumatoid arthritis..

An orally active adenosine receptor agonist that can induce acute cardiovascular toxicity and coronary vascular injury in vivo..

An orally active anabolic-androgenic steroid and a 19-nortestosterone derivative that has been widely used in scientific research as a hot ligand in androgen receptor (AR) ligand binding assays (LBAs) and as a photoaffinity label for the AR..

An orally active pterocarpanquinone that exhibits antitumoral and antileishmanial activity both in vitro and in vivo.

An orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo.

An orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI.

An orally active, non-peptide, selective antagonist for the NK1 receptor with Ki of 0.8 nM.