Cat. No. | Product name | CAS No. |
DC21448 |
Apicidin
Featured
Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay. |
183506-66-3 |
DC8276 |
Apilimod mesylate
Featured
Apilimod(STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM. |
870087-36-8 |
DC23406 |
Aplaviroc
Aplaviroc (GSK-873140. |
461443-59-4 |
DC23522 |
Aplaviroc HCl
Featured
Aplaviroc, also known as AK-602; GW-873140; GW873140A; ONO-4128, is a CCR5 entry inhibitor for the potential treatment of HIV infection. Aplaviroc (GW873140) binds specifically to human cellular CC chemokine receptor 5 (CCR5) and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5. |
461023-63-2 |
DC25100 |
Apogossypol
Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively. |
66389-74-0 |
DC23901 |
R-(-)-Apomorphine
Featured
Apomorphine hydrochloride hemihydrate is a non-selective dopamine agonist which activates both D1-likeand D2-like receptors, with some preference for the latter subtypes.. |
41372-20-7 |
DC10122 |
Apoptozole
Featured
Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. |
1054543-47-3 |
DC7003 |
Apricitabine
Apricitabine is a novel nucleoside reverse transcriptase inhibitor for the treatment of HIV infection that is refractory to existing drugs |
160707-69-7 |
DC10207 |
Aprotinin
Aprotinin is a serine protease inhibitor isolated from bovine lung which inhibits trypsin and chymotrypsin with Ki values of 0.06 pM and 9 nM, respectively. |
9087-70-1 |
DC9809 |
APS-3-77 HCl
Featured
APS-3-77 is the negative binder of KSR2. |
|
DC21999 |
APTO-253 hydrochloride
APTO-253 is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels. |
1422731-37-0 |
DC20672 |
APX001A
Featured
APX001 (APX 001A;E1210) is a novel broad-spectrum antifungal agent that inhibits the fungal protein Gwt1, demonstrates significantly acitive MIC50 and MIC90 values of 0.004 and 0.031 ug/ml (16 strains of C. auris). |
936339-60-5 |
DC11194 |
APX2009
APX2009 (APX-2009) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.45 uM for redox EMSA inhibition. |
1415030-15-7 |
DC11195 |
APX2014
APX2014 (APX-2014) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.2 uM for redox EMSA inhibition. |
1415030-17-9 |
DC23311 |
AQ-101
AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53. |
1353384-61-8 |
DC12155 |
AQ-13 dihydrochloride
AQ-13 dihydrochloride is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum. |
169815-40-1 |
DC20673 |
AQW-051
AQW-051 is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56. |
669770-29-0 |
DC23139 |
AQX 1125
AQX 1125 (Rosiptor) is a specific, orally bioavailable SHIP1 activator. |
782487-28-9 |
DC20674 |
AR03
AR03 (AR-03, AR 03, Ape1 repair inhibitor 03) is a novel small molecule inhibitor of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) endonuclease activity with IC50 of 5 uM. |
510721-85-4 |
DC8764 |
AR 231453
Featured
AR231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release; Antidiabetic agent. |
733750-99-7 |
DC22493 |
ARA-290(Cibinetide)
Featured
ARA-290 (Cibinetide) is a non-erythropoietic erythropoietin (EPO) derivative. |
1208243-50-8 |
DC8888 |
Ara-G
Featured
Ara-G (9-β-D-Arabinofuranosyl guanine) is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic. |
38819-10-2 |