| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC20482 | Opigolix | A novel potent gonadotrophin releasing hormone (GnRH) antagonist.. |
|
| DC22861 | CRT-0105950 | A novel potent LIMK inhibitor with IC50 of 0.3 nM and 1 nM for LIMK1 and LIMK2, respectively. |
|
| DC22862 | CRT-0105446 | A novel potent LIMK inhibitor with IC50 of 8 nM and 32 nM for LIMK1 and LIMK2, respectively. |
|
| DC23393 | BETi-211 | A novel potent small-molecule BET bromodomain (BRD) inhibitor that binds to BET proteins with Ki values of <1 nM. |
|
| DC22798 | ADA-07 | A novel potent TOPK inhibitor that effectively suppresses SUV-induced activation of MAPKs signal transduction resulting in reduced SUV-induced skin carcinogenesis. |
|
| DC21354 | MT47-100 | A novel potent, allosteric, simultaneously direct activator and inhibitor of AMPK complexes containing the β1 or β2 isoform, respectively. |
|
| DC23525 | AAT-008 | A novel potent, and selective prostaglandin EP4 receptor antagonist with binding IC50 of 2.4 nM. |
|
| DC22688 | AZD 3676 | A novel potent, combined serotonin 5-HT1A and 5-HT1B receptor antagonist with Ki of 0.13 and 2.4 nM in brain homogenates, respectively. |
|
| DC11986 | OX03050 | A novel potent, competitive squalene synthase inhibitor that upregulate the LDLR in mouse and human liver cell lines with EC50 of 26 nM. |
|
| DC20692 | ASP 8477 | A novel potent, highly selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 0.99, 1.65 and 57.3 nM for human FAAH-1, FAAH-1 (P129T) and FAAH-2, respectively. |
|
| DC21507 | PHA-408 | A novel potent, highly selective, ATP-competitive IKK-2 inhibitor with IC50 of 40 nM, 350-fold selectivity over IKK-1. |
|
| DC23309 | BCL6 inhibitor 8c | A novel potent, in vivo-active BCL6 inhibitor with IC50 of 0.1 uM in ELISA assays. |
|
| DC21209 | KW-2581 | A novel potent, irreversible and orally active inhibitor of steroid sulfatase (STS) with IC50 of 13 nM in ZR-75-1 cells. |
|
| DC11769 | MPO-IN-28 Featured | A novel potent, irreversible Myeloperoxidase (MPO) inhibitor with IC50 of 44 nM. |
|
| DC21058 | GNS-1481 | A novel potent, irreversible, T790M mutant-selective inhibitor of mutant EGFR with IC50 of 6.2, 3.4 and 4.2 nM for L858R-T790M, T790M and Del19-T790M, respectively. |
|
| DC21059 | GNS-1486 | A novel potent, irreversible, T790M mutant-selective inhibitor of mutant EGFR with IC50 of 8.3, 4.2 and 4.3 nM for L858R-T790M, T790M and Del19-T790M, respectively. |
|
| DC24024 | Z-360 | A novel potent, orally active CCK-2/gastrin receptor antagonist with Ki of 0.47 nM. |
|
| DC21707 | STX-681 | A novel potent, orally active, dual-acting aromatase and steroid sulfatase (STS) inhibitor with ICI0 of 0.82 nM and 39 nM, respectively. |
|
| DC20806 | BMS-852927 | A novel potent, partial LXRβ-selective agonist (EC50=9 nM) with 20% LXRα and 88% LXRβ activity compared to a full pan agonist in transactivation assays. |
|
| DC22745 | SLx-4090 Featured | A novel potent, selective and orally active enterocytic microsomal triglyceride transfer protein (MTP) inhibitor that inhibits only MTP localized to enterocytes with IC50 of 6 nM. |
|
| DC21667 | SMM-295 | A novel potent, selective cannabinoid receptor 2 (CB2) agonist with Ki of 12 nM, >30-fold selectivity over CB1. |
|
| DC20841 | BRD6989 Featured | A novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex. |
|
| DC22940 | SKF-32802 | A novel potent, selective hERG potassium channel (Kv11.1) activator that induces a leftward shift in the voltage dependence of activation.. |
|
| DC21703 | STAT5 inhibitor 17f Featured | A novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation. |
|
| DC22938 | ICA-027243 Featured | A novel potent, selective KCNQ2/Q3 (Kv7.2/Kv7.3) potassium channel opener/activator with EC50 of 0.38 uM.. |
|
| DC22741 | RY796 R-form | A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively. |
|
| DC22744 | RY796 racemate | A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively. |
|
| DC22886 | TASP 0433864 | A novel potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity. |
|
| DC20441 | MAO-B inhibitor 8f | A novel potent, selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 29-56 nM. |
|
| DC20467 | mTOR inhibitor 10 | A novel potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM. |
|
