| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC23862 | MET inhibitor Compound 1 | A novel potent, selective orally bioavailable MET tyrosine kinase inhibitor with IC50 of <1 nM and 12 nM for unphosphorylated and phosphorylaed MET, respectively. |
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| DC22977 | Lu AF-58027 | A novel potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively. |
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| DC21458 | (S)-PBMC | A novel potent, selective TRPM8 antagonist with IC50 of 15.6 nM (hTRPM8). |
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| DC20951 | DFL 23448 | A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold. |
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| DC21747 | tBPC | A novel potent, selective Y4R positive allosteric modulator (EC50=5.1 uM) that potentiates Y4R activation in G-protein signaling and arrestin3 recruitment experiments. |
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| DC22700 | DETQ | A novel potent, selective, allosteric and orally active dopamine D1 receptor potentiator with Kb of 26 nM. |
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| DC22857 | Pyr-1 | A novel potent, selective, cell permeable and ATP competitive LIMK inhibitor. |
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| DC23672 | Gemigliptin Featured | A novel potent, selective, competitive and orally active DPP4 inhibitor with potential for the treatment of type 2 diabetes. |
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| DC20685 | AS2795440 | A novel potent, selective, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=2 nM). |
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| DC20782 | BI 689648 | A novel potent, selective, orally active aldosterone synthase inhibitor with IC50 of 2 nM, displays 150-fold selectivity over related cortisol synthase. |
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| DC22673 | SCH 486757 | A novel potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors. |
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| DC21441 | ONO-2952 | A novel potent, selective, orally active translocator protein 18 kDa (TSPO/PBR) antagonist with Ki of 0.33-9.3 nM for both rat and human TSPO. |
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| DC22740 | RO 5126946 | A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM. |
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| DC20690 | ASP 2905 Featured | A novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM. |
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| DC21522 | Balixafortide(POL6326) Featured | Balixafortide(POL 6326) is a novel potent, selective, peptidic CXCR4 antagonist that interferes with the tumor-protective microenvironment and sensitizes tumor cells to chemotherapy. |
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| DC22600 | HI-TOPK-032 Featured | A novel potent, specific TOPK inhibitor that has no effect on ERK1, JNK1, or p38 kinase activity. |
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| DC23487 | AS2575959 | A novel potent, specific, orally available GPR40 agonist that influences glucose-dependent insulin secretion both in vitro pancreas β-cell-derived cells and in vivo. |
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| DC23450 | SAS-1121 | A novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 16.2 nM, 574-fold selectivity over sigma 1 receptors.. |
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| DC23465 | DKR-1051 | A novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 61 nM, 9-fold selectivity over sigma 1 receptors (Ki=556 nM). |
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| DC22370 | Meptyldinocap | A novel powdery mildew (Erysiphe necator) fungicide that shows protectant and post-infective activities. . |
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| DC22592 | Amiselimod hydrochloride (MT-1303 hydrochloride) Featured | A novel prodrug S1P receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators. |
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| DC26112 | SLMP53-1 Featured | SLMP53-1 is a novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells. |
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| DC25071 | PDE6δ inhibitor 8 | A novel selective small molecule inhibitor of PDE6δ/KRas interaction with Kd of 358 pM.. |
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| DC23742 | Rac1-IN-6 | A novel selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 88±48 nM. |
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| DC23749 | Rac1-IN-1 | A novel selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 95±21 nM. |
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| DC21702 | SC-99 Featured | A novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation but has no effects on other transcription factors such as NF-κB, and kinases such as AKT, ERK, and c-Src. |
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| DC22660 | Tenovin-D3 | A novel selective, small-molecule inhibitor of sirtuin SITR2 with IC50 of 21.8 uM. |
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| DC22961 | ITP-2 | A novel small molecule activator of Kv 11.1 (hERG) channel (216% over control at 3 uM for hERG1a activation). |
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| DC22982 | Aldi-6 | A novel small molecule ALDH inhibitor with IC50 of 600 nM, 800 nM and 1000 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. |
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| DC20650 | AKI603 Featured | AKI-603 is a novel small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent; disrupts normal spindle structure, and induces cell-cycle arrest; t; suppresses stem cell properties in breast cancer cells, and also suppresses the expression of self-renewal genes (β-catenin, c-Myc, Sox2, and Oct4); reduces xenograft tumor growth after intragastric administration. |
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