| DC49847 |
BSB |
BSB is a Congo red-derived fluorescent probe. BSB binds not only to extracellular amyloid β protein, but also many intracellular lesions composed of abnormal tau and synuclein proteins. BSB acts as a prototype imaging agent for Alzheimer's disease. |
|
| DC49848 |
Immune initiator-1 |
Immune initiator-1 (Compound 1a) is an amino acid-modified near-infrared Aza-BODIPY photosensitizer, acts as an immune initiator for potent photodynamic therapy in melanoma. |
|
| DC49849 |
ETZ |
ETZ (C3-CA-DTZ) is a promising luciferase substrate (prosubstrate) activatable in vivo by nonspecific esterase to enhance the brain delivery of the luciferin. |
|
| DC49850 |
Glucosylceramide synthase-IN-1 |
Glucosylceramide synthase-IN-1 (T-036) a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research. |
|
| DC49851 |
AAK1-IN-3 TFA |
AAK1-IN-3 TFA, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC50 of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research. |
|
| DC49852 |
Deoliosyl-3C-α-L-digitoxosyl-MTM |
Deoliosyl-3C-α-L-digitoxosyl-MTM, a compound, shows decreased anti-cancer activity compared to mithramycin. |
|
| DC49853 |
ZL-Pin01 |
ZL-Pin01 is a high potent covalent Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) inhibitor. ZL-Pin01 shows potent disruption of the Pin1-substrate interaction with an IC50 of 1.33 μM. |
|
| DC49854 |
Allyl (2-aminoethyl)carbamate hydrochloride |
Allyl (2-aminoethyl)carbamate hydrochloride is a cleavable linker. |
|
| DC49855 |
12-Hydroxystearic acid |
12-Hydroxystearic acid is a structurally simple and cost-effective low molecular weight organogelator, and its metal salts and derivatives find roles in many important applications. |
|
| DC49856 |
ST638 |
ST638 is a potent tyrosine kinase inhibitor with an IC50 of 370 nM. |
|
| DC49857 |
ANKRD22-IN-1 |
ANKRD22-IN-1 is a potent inhibitor of ANKRD22. ANKRD22-IN-1 promotes the expansion of gastrointestinal mucosal epithelial stem cells and indirectly activates the Wnt classical pathway, which helps the recovery of damaged gastrointestinal mucosal tissues in the body (extracted from patent CN111205231B). |
|
| DC49858 |
Dodecyltrimethylammonium bromide
Featured
|
Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction. |
|
| DC49859 |
1-Myristin-2-Olein-3-Butyrin |
1-Myristin-2-Olein-3-Butyrin (1-Myristoyl-2-Oleoyl-3-Butyryl-rac-glycerol) is a triacylglycerol. |
|
| DC49860 |
RJ-34 |
RJ-34, an aristolactam analogue, exhibits potent antitumor activities against a broad array of cancer cell lines with GI50 values in the subnanomolar range (GI50 <0.1 nM for A431, MES-SA, MES-SA/DX5, HCT-15, and HCT-15/CLO2 cells). |
|
| DC49861 |
Pseudouridine 5'-triphosphate
Featured
|
pseudouridine-5’-triphosphate (Pseudo-UTP) is one of the most commonly used modified nucleoside for the polymerase-mediated synthesis of RNA molecules. Compared with uridine-containing unmodified mRNAs, the application of pseudouridine-containing modified mRNAs exhibits better nuclease stability, immunogenicity, and translational properties. |
|
| DC49862 |
(E)-UK122 TFA |
(E)-UK122 TFA is the isomer of UK122 TFA. UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. |
|
| DC49863 |
Drisapersen |
Drisapersen, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations. |
|
| DC49864 |
(Rac)-Neurodegenerative Disorder-Targeting Compound 1 |
(Rac)-Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor (extracted from patent WO2010128102A1, compound 63) . |
|
| DC49865 |
Butyryl-Coenzyme A sodium |
Butyryl-Coenzyme A (Butyryl CoA) sodium is a coenzyme A-containing derivative of Butyric acid. Butyryl-Coenzyme A sodium is responsible for the final step of Butyrate production in bacteria. |
|
| DC49866 |
MK-1903 |
MK-1903 is a potent and selective hydroxycarboxylic acid receptor 2 (HCA2, GPR109A) full agonist. |
|
| DC49867 |
AP24600 |
AP24600 is an inactive metabolite of Ponatinib. |
|
| DC49868 |
11β-HSD1-IN-6 |
11β-HSD1-IN-6 is a an 11β-HSD-1 inhibitor. The 11β hydroxysteroid dehydrogenase enzymes (11β-HSDs) mediate the interconversion of the glucocorticoid (GC) corticosterone or cortisol to an inactive form, 11-dehydrocorticosterone (11-DHC) or Cortisone, respectively. |
|
| DC49869 |
Bismuth subnitrate |
Bismuth subnitrate (Bismuth(III) oxynitrate) is a bismuth(III) compound that bears significant medical uses (e.g., as an antidiarrheic agent). Bismuth subnitrate is a simple, readily available and effective catalyst for the Markovnikov-type hydration of terminal acetylenes. |
|
| DC49870 |
ML089 |
ML089 is a potent, selective, and orally available phosphomannose isomerase (PMI) inhibitor with an IC50 of 1.3 µM. ML089 can be used for the research of congenital disorder of glycosylation Ia. |
|
| DC49871 |
hGPR91 antagonist 3
Featured
|
hGPR91 antagonist 3 (Compound 5g) is a potent, selective, and orally active antagonist of hGPR91 (%F: 26). hGPR91 antagonist 3 has the potential for the research of hypertension, autoimmune disease and retinal angiogenesis. |
|
| DC49872 |
GSK854
Featured
|
GSK854 is a potent Inhibitor of Troponin I-Interacting Kinase (TNNI3K). GSK854 is a suitable lead for identifying new cardiac medicines and have been employed as in vivo tools in investigational studies aimed at defining the role of TNNI3K within heart failure. |
|
| DC49873 |
XA-E |
XA-E is a compound purified from a methanol-ethyl acetate extract from A. keiskei. XA-E displays anti-ZIKV activity with an IC50 value of 22.0 µM. |
|
| DC49874 |
JW480 |
JW480 is a potent and selective inhibitor of a serine hydrolase enzyme KIAA1363. |
|
| DC49875 |
N-Palmitoyl dopamine |
N-Palmitoyl dopamine (PALDA) is a endogenous, long-chain, linear fatty acid dopamide, which is inactive on TRPV1. N-Palmitoyl dopamine displays 'entourage' effects on endovanilloids N-arachidonoyl-dopamine (NADA) and anandamide. |
|
| DC49876 |
2'-Deoxy-5-formylcytidine |
2'-Deoxy-5-formylcytidine is an effective internal triplet photosensitizer in DNA. 2'-Deoxy-5-formylcytidine could act as a new hot spot in DNA photodamage. |
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