| DC50298 |
Trypacidin |
Trypacidin is the conidia-bound metabolite with antiprotozoal activity. Trypacidin has a protective function against phagocytes both in the environment and during the infection process. |
|
| DC50299 |
epi-Progoitrin |
epi-Progoitrin is the major thioglucoside of Crambe abyssinica seed. |
|
| DC50300 |
Stachybotrysin B |
Stachybotrysin B is a phenylspirodrimane derivative. Stachybotrysin B is isolated from Stachybotrys chartarum CGMCC 3.5365. |
|
| DC50301 |
Diallyl disulfide |
Diallyl disulfide inhibits human squalene monooxygenase with an IC50 of 400 μM for squalene epoxidation. |
|
| DC50302 |
2,3-Dihydro-3-methoxywithaferin A |
2,3-Dihydro-3-methoxywithaferin A is an analogue of 2,3-dihydrowithaferin-A. 2,3-Dihydro-3-methoxywithaferin A inhibits proiiferation of P388 cells. |
|
| DC50303 |
Methyl tetracosanoate |
Methyl tetracosanoate is used as an analytical standard in chromatographic assays. |
|
| DC50304 |
Gluconapin potassium |
Gluconapin potassium is the precursor of sulforaphane. Sulforaphane is a potent anti-cancer isothiocyanate. |
|
| DC50305 |
OB3 |
OB3, a derivative of Leptin, show more effective than leptin in reducing obesity and diabetes in mouse models. OB3 can reduce Leptin-related inflammation and proliferation in hepatocellular carcinoma cells. |
|
| DC50306 |
Hortein |
Hortein is a natural product from the fungus Hortaea werneckii associated with the sponge Aplysina aerophoba. |
|
| DC50307 |
Tajixanthone |
Tajixanthone is the fungus metabolite from Aspergillus variecolor. |
|
| DC50308 |
Mycestericin C |
Mycestericin C is a compound isolated from the culture broth of Mycelia sterilia ATCC 20349. Mycestericin C suppresses the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction. |
|
| DC50309 |
Muristerone A |
Muristerone A is a phytoecdysteroid analog of ecdysone and a potent agonist of ecdysteroid receptor with a Kd of 1 nM. |
|
| DC50310 |
(-)-(E)-Guggulsterone |
(-)-(E)-Guggulsterone is the metabolite of Z-guggulsterone. Guggulsterone is an active constituent of guggulipid, an ayurvedic drug derived from Commiphora mukul. Guggulsterone has hypolipidaemic activity. |
|
| DC50311 |
Agonodepside B |
Agonodepside B is a compound isolated from a nonsporulating filamentous fungus, F7524. |
|
| DC50312 |
Anhydroophiobolin A |
Anhydroophiobolin A is a potent inhibitor of photosynthesis with IC50s of 77 and 14 mM in the photosynthesis of chlorella and spinach, respectively. Anhydroophiobolin A is an analog of Ophiobolin A. |
|
| DC50313 |
Glucoarabin |
Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity. |
|
| DC50314 |
Choline oxidase |
Choline oxidase catalyzes the oxidation of choline to glycine betaine via betaine aldehyde in glycine betaine biosynthesis and betaine acts as an osmolyte. Choline oxidase has potential in enzymatic betaine production. |
|
| DC50315 |
Aspulvinone O |
Aspulvinone O is a natural inhibitor of aspartate transaminase 1 (GOT1). GOT1 plays an important role in energy metabolism and Reactive Oxygen Species (ROS) balance. GOT1 may serve as an important target in PDAC. Aspulvinone O suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism. |
|
| DC50316 |
11-O-Methylpseurotin A |
11-O-Methylpseurotin A is a compound of mixed polyketide synthase–nonribosomal peptide synthetase (PKS/NRPS) origin. 11-O-Methylpseurotin A selectively inhibits a Hof1 deletion strain. |
|
| DC50317 |
γ-AA peptide P6 (Cyclic γ-AA Peptide 6)
Featured
|
γ-AA peptide P6 (Cyclic γ-AA P6) is a potent activator of E6 associated protein (E6AP). γ-AA peptide P6 can stimulate the self-ubiquitination of E6AP and E6AP-catalyzed substrate ubiquitination in reconstituted reactions in vitro. γ-AA peptide P6 can also enhance the ubiquitination of E6AP substrates in the cell and accelerate their degradation by the proteasome. |
|
| DC50318 |
3-(2-Hydroxyethyl) thio withaferin A |
3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding. |
|
| DC50006 |
Cinobufagin (Cinobufagine)
Featured
|
Cinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer. IC50 value: Target: In vitro: Cinobufagin inhibited proliferation of cancer cells at doses of 0.1, 1, or 10 μM after 2–4 days of culture. Cytotoxicity of cinobufagin on the DU145 and LNCaP cells was dose-dependent. Cinobufagin increased [Ca2+]i and apoptosis in cancer cells after a 24-hr culture as well as caspase 3 activities in DU145 and PC3 cells and caspase 9 activities in LNCaP cells [1]. Cinobufagin suppresses cell proliferation and causees apoptosis in prostate cancer cells via a sequence of apoptotic modulators, including Bax, cytochrome c and caspases [2]. |
|
| DC50007 |
Etoposide
Featured
|
>98%,Standard References |
|
| DC50008 |
Colchicine
Featured
|
Colchicine is a potent therapeutic tool against COVID-19. Colchicine is a tricyclic alkaloid that is extracted from the plant Colchicum autumnale. Colchicine acts as a potent inhibitor of tubulin polymerization. |
|
| DC70002 |
Diquat dibromide |
Diquat dibromide is a comprehensive herbicide commonly used in the cultivation of cotton, soybeans, and other crops to combat unwanted weeds. Diquat dibromide has an IC50 of 60 mg/L in the Allium root growth inhibition test. |
|
| DC70003 |
SLEC-11 |
SLEC-11 acts as a potential synthetic lethal lead for the treatment of gastric cancer. AL-GDa62 shows EC50 of 12.2 μM and 8.2 μM for isogenic mammary epithelial cells MCF10A-WT (wild-type) and MCF10A-CDH1-/-. |
|
| DC70004 |
Custirsen |
Custirsen is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance. |
|
| DC70005 |
Triton X-100 |
Triton X-100 is a non-denaturing detergent that solubilizes lipid membranes. Triton X-100 is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Triton X-100 is listed as an excipient in certain vaccines including split virus influenza vaccines. Triton X-100 is a nonionic surfactant. |
|
| DC70006 |
Anticancer agent 37 |
Anticancer agent 37 (compound 18), a sulfonylurea derivative, is a potent anticancer agent. Anticancer agent 37 inhibits HePG2 cell growth with an IC50 of 17.2 µg/mL. |
|
| DC70007 |
Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine
Featured
|
Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine alters the lifespan of a eukaryotic organism. |
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