| DC49976 |
3CPLro-IN-2 |
3CPLro-IN-2 (compound C1) is a potent and orally active inhibitor of SARS-CoV-2 3CLpro with an IC50 and Ki of 1.55 and 6.09 μM, respectively. 3-Chymotrypsin-like cysteine protease (3CLpro) is an indispensable protein in viral replication and represents an attractive drug target for fighting COVID-19. |
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| DC49977 |
SC-435 |
SC-435 is an apical sodium-dependent Bile acid (BA) transporter inhibitor. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations. |
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| DC49978 |
Tidiacic |
Tidiacic is a hepatoprotective agent that acts as an antioxidant and a sulfur donor. |
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| DC49979 |
2-Nitro-5-thiocyanatobenzoic acid |
2-Nitro-5-thiocyanatobenzoic acid (NTCB) is a highly reactive reagent that transfers its cyano group rapidly to a nucleophilic thiolate. 2-Nitro-5-thiocyanatobenzoic acid has been proposed as a reagent for converting thiol groups in proteins into their S-cyano derivatives. |
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| DC49980 |
APF |
APF is a fluorescence probe that can selectively, and dose dependently detect certain species among ROS and that are highly resistant to autoxidation. APF can be used in enzymatic and cellular systems. |
|
| DC49981 |
BMPO |
BMPO (BocMPO) is a cyclic nitrone spin trap. BMPO offers several advantages over the existing spin traps in the detection and characterization of thiyl radicals, hydroxyl radicals, and superoxide anions in biological systems. |
|
| DC49982 |
Isaxonine |
Isaxonine acts as a modifier of the surface pH of the bilayer. Isaxonine accelerates the rate of peripheral nerve regeneration, stimulate axonal sprouting and promote motor and sensory function recovery. Isaxonine is a neurotrophic agent. |
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| DC49983 |
NFAT Inhibitor-2 |
NFAT Inhibitor-2 is a potent inhibitor of calcineurin NFAT signalling. Calcineurin is a serine/threonine protein phosphatase regulated by Ca2+ and calmodulin. NFAT Inhibitor-2 has the potential for the research of inflammatory disease, an autoimmune disorder, a cardiovascular disease, a neurodegenerative disease, a disease occurring with uncontrolled cell proliferation and/or differentiation, an angiogenesis-related disease, an allergy, anaphylaxis and alopecia (extracted from patent WO2016207212A1, compound 17). |
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| DC49984 |
KDdiA-PC |
KDdiA-PC is a kind of oxidized LDL (oxLDL), and is a ligand for the macrophage scavenger receptor CD36. |
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| DC49985 |
Buramate |
Buramate exhibits neuroprotective and anticonvulsant activities. |
|
| DC49986 |
Salacetamide |
Salacetamide (N-Acetylsalicylamide) is the stable isomer of O-Acetylsalicylamide, is a product for proteomics research. |
|
| DC49987 |
5β-Cholanic acid
Featured
|
5β-Cholanic acid can be used for 5β-Cholanic acid derivatives synthesis. |
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| DC49988 |
BMS-566419 |
BMS-566419 is an acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase (IMPDH). Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme in the de novo synthesis of guanosine nucleotides. BMS-566419 has clinical utility for the research of transplant rejection. |
|
| DC49989 |
DCVJ |
DCVJ (9-(2,2-Dicyanovinyl)julolidine), a molecular rotor and unique fluorescent dye, binds to tubulin and actin, and increases its fluorescence intensity drastically upon polymerization. DCVJ also binds to phospholipid bilayers and increases its fluorescence intensity. DCVJ can detect the kinetic process of degranulation of mast cells. |
|
| DC49990 |
Tilomisole |
Tilomisole (Wy 18251) is a benzimidazothiazole experimental drug with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation. |
|
| DC49991 |
1,2-Dilauroyl-sn-glycerol
Featured
|
1,2-Dilauroyl-sn-glycerol is a saturated diacylglycerol and may play a role in second messenger signal transduction. |
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| DC49992 |
Dioctanoylglycol |
Dioctanoylglycol (Ethylene glycol dicaprylate), a diacylglycerol analog, is a diacylglycerol kinase (DGK) inhibitor (Ki of 58 μM). |
|
| DC49993 |
Chrysamine G |
Chrysamine G, a carboxylic acid analogue of Congo Red, can be used as a probe of amyloid deposition in Alzheimer's disease. Chrysamine G also can inhibit Aβ-induced toxicity in PC12 cells. |
|
| DC49994 |
Anticancer agent 38 |
Anticancer agent 38 (compound 19), a sulfonylurea derivative, is a potent anticancer agent. Anticancer agent 38 inhibits A431 cell growth with an IC50 of 5.2 µg/mL. |
|
| DC49995 |
Pyruvate Carboxylase-IN-1 |
Pyruvate Carboxylase-IN-1 (compound 37) is a potent inhibitor of pyruvate carboxylase (PC) with IC50s of 0.204 and 0.104 μM in cell lysate-based and cell-based PC activity, respectively. Pyruvate Carboxylase-IN-1 is a natural analog of erianin. Pyruvate Carboxylase-IN-1 inhibites the enzymatic activity of PC, mediating the anticancer effect in human hepatocellular carcinoma (HCC). |
|
| DC49996 |
Coelenteramine 400a
Featured
|
Coelenteramine 400a (Bisdeoxycoelenterazine), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm. |
|
| DC49997 |
GYKI-13380 |
GYKI-13380 is an appetite suppressant. GYKI-13380 has the potential for the research of neurology diseases. |
|
| DC49998 |
Quin C1 |
Quin C1 is a highly specific and potent agonist for formyl peptide receptor 2 (FPR2/ALX). Quin-C1 significantly reduces the neutrophil and lymphocyte counts in BALF, diminishes expression of TNF-α, IL-1β, KC, and TGF-β1, and decreases collagen deposition in lung tissue. Quin C1 has the potential for the research of lung injury. |
|
| DC49999 |
TASIN-1 |
TASIN-1 is a selective inhibitor of truncated APC gene (adenomatous polyposis coli gene) and exerts cytotoxic effects through inhibition of cholesterol biosynthesis. TASIN-1 represents a potential therapeutic strategy for prevention and intervention in CRC with mutant APC. |
|
| DC50000 |
m7GpppApG |
m7GpppApG is a trinucleotide mRNA 5' cap analog that can be used for RNA synthesis in vitro. |
|
| DC50003 |
MIF-IN-1
Featured
|
MIF-IN-1 (compound 14) is a potent macrophage migration inhibitory factor (MIF) inhibitor (pIC50=6.87). |
|
| DC50009 |
Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine
Featured
|
Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine is an active compound. |
|
| DC50014 |
S(-)-Bisoprolol |
S(-)-Bisoprolol is a S(-)-enantiomer of Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research. |
|
| DC50015 |
2-Hydroxyestradiol-13C6 |
2-Hydroxyestradiol-13C6 is the 13C-labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity. |
|
| DC50016 |
WH-10417-099 |
WH-10417-099 is a degrader that could collectively induce degradation of the largest number of unique kinases (>125 unique kinases). |
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