Natural inhibitor of the autophagy pathway, enhancing immune function, suppressing MAPK and NFκB, showing anti-inflammatory, hypoglycemic, vasorelaxative, and antiproliferative activities

Selectiveγ

Selectiveγ

Selectiveγ‑Aminobutyric Acid(C) (GABAC) Antagonist

Natural selective estrogen receptor modulator, showing higher binding affinity to ER-β than ER-α with both estrogenic and antiestrogenic effects depending on the E2 concentration

Mutually Orthogonal Bioorthogonal Amino Acid, Enabling Efficient Protein Dual-Labeling in Cells

Clickable fluorescent probe, enabling dynamic imaging of cell surface and intracellular fucosylation of glycoproteins and glycolipids.

Photoreactive L-phenylalanine derivative, being as a photo cross-linking probe to incorporate into proteins, including ion channels, transporters and GPCRs

Ca ionophore. potentiating responses to NMDA, but not quisqualate

Novel Transthyretin (TTR) Amyloidogenesis Inhibitor, stabilizing the TTR tetramer by binding to the allosteric sites on the molecular surface of the TTR tetramer

Prodrug of 7-Cl-kynurenic acid (7-Cl-KYNA), a potent, selective antagonist of the NMDA/glycine receptor

Novel selective ligand of the Transport Inhibitor Resistant 1 (TIR1)

Potent Antifungal Inhibitor of Chitin Synthesis

Potent agonist of tropomyosin-receptor-kinase B (TrkB) receptor, possessing robust anti-apoptotic activity, promoting neurogenesis, and exhibiting potent antidepressant effect

Dopamine reuptake inhibitor

Novel Potent and Selective Kappa Opioid Receptor Antagonist

Novel ligand for LTA4H, dose responsively reducing LTB4 production in human neutrophils

Novel anti-austerity agent, inducing PANC-1 human pancreatic cancer cell death under nutrition starvation via inhibition of Akt/mTOR pathway

Inhibitor of Androgen_receptor>androgen receptor (AR) transcriptional activity, more effective than resveratrol in inhibiting AKT>Akt phosphorylation

Useful pharmaceutical building block

Useful pharmaceutical building block

Bulding Block

Inhibitor of T-type voltage-gated calcium channels (Cav3), inhibiting isoforms Cav3.1, Cav3.2, and Cav3.3, decreasing nifedipine-resistant phenylephrine-induced vasoconstriction via Cav3.2 blockade

Novel inhibitor of HCV NS3-NS4A Serine Proteinase

Novel Inducer of G2/M arrest, Apoptosis and Autophagy in Cancer Cells

5-alpha-hydroxy-laxogenin is a derivative of the spirostane-type steroid, laxogenin. 5α-Hydroxy-laxogenin can be used as a plant-based anabolic agent as a dietary supplement.

Adenosine kinase inhibitor

Brominated luciferin, being more cell permeant than luciferin

Novel potent δ-selective allosteric modulator, Ki(α4β1δ) 0.06 µM

Novel potent δ-selective allosteric modulator, Ki(α4β1δ) 0.14 µM

Novel HIV-1 integrase inhibitor

HIV-1 integrase inhibitor

Rare base found in mammalian DNA, having functional roles in DNA that go beyond being a demethylation intermediate

Novel palladium-activated 5-FU prodrug, being completely innocuous to cells and highly resistant to metabolization by primary hepatocytes and liver S9 fractions (the main metabolic route for 5-FU degradation), and rapidly converted into 5-FU in the presen

Serotonin metabolite, systemically inhibiting RAS/MAPK signaling in different organs of C. elegans

Novel selective 5-HT 2C agonist with >300-fold functional selectivity over 5-HT 2B and >70-fold functional selectivity over 5-HT 2A , reducing food intake in an acute rat feeding model

5-HT3 antagonist 4 is a 5-HT3 receptor (5HT3R) antagonist. 5-HT3 antagonist 4 prevents diabetes-induced depressive phenotypes in mice.

Novel potent and selective G protein-biased 5-HT 7 R Antagonist, significantly reducing self-grooming duration time to the level of wild-type mice

Metabolite of dantrolene

Morin isomer, antioxidant

Active metabolite of diclofenac, targeting COX and CaMKIIα hub domain

Melatonin analogue, selectively binding on MT3 subsites

Natural proangiogenic agent, downregulating the cellular uptake of all- trans-retinoic acid (atRA) under hypoxia

Novel potent δ-selective allosteric modulator, displayed at least 60-fold selectivity for α4β1δ over α4β1γ2 receptor subtypes, Ki(α4β1δ

Neutral allosteric site ligand of the metabotropic glutamate receptor subtype 5 (mGlu5), blocking the effects of both the allosteric antagonist MPEP and potentiator CDPPB

Novel highly potent nonsteroidal antiandrogen (NSAA)

Inducer of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells

PhIP metabolite

Natural inhibitor of hedgehog (Hh) signal transduction, diminishing characteristics of cancer stem cells, leading to decreasing production of the Hh target proteins BCL2, PTCH1, and BMI1

Blocker of the formation of the FAK/Mdm-2 complex; subsequently, activating p53 and caspase-8 and leading to increase detachment and apoptosis in breast and colon cancers

Novel O-GlcNAc transferase (OGT) inhibitor, inducing dose- and time-dependent decreases in O-GlcNAc levels

Novel FUdR prodrug. possessing a better tumor inhibition rate and a better metabolic stability than FUdR through a ATB0, -mediated prodrug approach

Metabolite of soy isoflavone; Antioxidant

Metabolite of soy isoflavones

Metabolite of soy isoflavones

Potent and selective nociceptin opioid receptor (NOP) agonist

Novel potent MtbCoaBC inhibitor (IC50: 0.08 µM)

Antioxidant, inhibiting Cu(2+)-mediated oxidation of human low density lipoprotein (LDL)

Novel methuselah (Mth)-specific antagonist

Novel fluorescent probe for near-IR live-cell super-resolution imaging

Widely used fucosylation probe, strongly inhibiting fucosylation and GDP-fucose synthetase FX, halting hepatoma invasion

Broad-spectrum metabolic inhibitor, inhibiting glucose uptake, decreasing glycolysis and ATP with minimal changes in ROS and mitochondrial respiration

Natural blocker of Kv1.2 channels, not involving direct occlusion of the outer pore but depending on C-type inactivation

Precursor for radio-labelled triphosphate to be used in chemical genetics approach

ATP analog for specific interaction with modified receptor proteins in chemical genetics approach

Novel inhibitor of STAT3 activation, suppressing proliferation, inducing cell cycle arrest and apoptosis in breast cancer

Membrane-permeant activator of cAMP-dependent protein kinase (PKA), selectively for site A-I of PKA

Novel selective ligand of the Transport Inhibitor Resistant 1 (TIR1)

Novel potent activator of insulin receptor (IR) signaling in cell models and insulin-responsive tissues, alleviating diabetes

Novel potent blocker of ZIKV infection at a pre-fusion step or during fusion

Novel probe for detecting tryptophan metabolites in ex vivo tissue samples via 19F nuclear magnetic resonance

Nornicotine metabolite

Novel inhibitor of Lipid II with less cytotoxicity and improved pharmacokinetic profile

Novel cationic antimicrobial peptide (CAP)

Selective agonist of protein kinase A, strongly preferring the A site of cAK II

Novel high-affinity NR5A probe for fluorescence polarization competition assays, tightly binding the NR5A receptors and detecting direct binding of synthetic and phospholipid ligands

Novel highly potent agonist of GPR84

Metabolite of soy isoflavone, preventing bone loss and reversing the unfavorable changes of lipid metabolism

The precursor for preparing 11C-PiB, a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis

Novel inhibitor of 6-phosphogluconate dehydrogenase (6PGD)

Novel potent inhibitor of chikungunya virus (CHIKV) replication

Thiopurine metabolite, blocking activation of GTPase Rac1 in T lymphocytes

Glucocorticoid with anti-inflammatory and immunosuppressive activities

Novel potent cell growth inhibitor, suppressing the cytokine-Induced β-cell apoptosis

Agonist of tyrosine receptor kinase B (TrkB)

Novel NIR fluorescent heptamethine cyanine dye IR-780 and 5FU conjugate, exhibiting enhanced CSCs-targeting therapeutic effects

Natural antiplasmodial agent

Ligand binding to the orthosteric site of D2 receptor

Useful pharmaceutical building block

Novel Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist, Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells

Fluorescent amino acid for protein labeling

Natural hypoxia-inducible factor-1α (HIF-1α) inhibitor, targeting the protein activity which could stabilize HIF-1α

Potent inhibitor of AChE in treatment of cognitive manifestation of AD

Non-selective NOS inhibitor

Potent and selective calcium sensing receptor agonist

Potent dual PKCθ/δ inhibitor, efficiently inhibiting tumor growth in pancreatic cancer (PC) by inducing cellular apoptosis and suppressing the NF-κB/p-P65 pathway

Precursor of paclitaxel, a anti-tumor agent

Novel tumor-targeting NIR fluorophore-conjugated hypoxic tumor inhibitor, preferentially accumulating in hypoxic tumor cells, sensitively outlining the tumor contour, and effectively inhibiting tumor growth synergistically by chemotherapy and radiotherapy

Carcinogenic adduct, covalently binding DNA bases and promoting mutagenesis near the adduct site

Novel activator of cAMP-dependent protein kinase (PKA) with high selectivity for site B-I of PKA

Building block for syntheses of 8-BuS-AMP, ADP, ATP, and c-AMP

Potent and selective inhibitor of NTPDase1

Potent and selective inhibitor of NTPDase1

Potent and selective inhibitor of NTPDase1

Building Block

Inhibitor of RNA synthesis

Specific non-nucleoside RT inhibitor (NNRTI) of HIV-1 RT

Novel inhibitor of nitric oxide formation in macrophages independent of effects on TNF

Antitumor agent, displaying cytotoxicity against the human cancer cell lines, including MDA231, T-47D, Hs578t, SaoS2, K562, SKHep1,and Hep3B

Unique cytoprotective mediator, inhibiting oxidative stress; Novel probe of the protein S-guanylation

Potent activator of cGMP-dependent protein kinase Ia, Ib and type II as well as of cGMP- gated ion channels

Potent and selective activator of protein kinase A (PKA) type I and II

Dual human A2a antagonist/MAO-B inhibitor

Endogenous peripheral TRPV1 ligand

Novel ATP-competitive GSK-3ß inhibitor, exhibiting potent antiproliferative activity

Inhibitor of cyclin-dependent kinases

Novel, potent, mutant-selective BET bromodomain inhibitor, showing >100-fold selectivity for the L/V mutant over wild-type and excellent DMPK properties

Novel natural anticancer agent, exhibiting potent cytotoxicity against PANC-1 human pancreatic cancer cell line under the normoglycemic condition

Natural IDO1 inhibitor, cytotoxic and antiplasmodial agent

Selective TRPV1 antagonist

Fluorogenic A9 Peptide Probe, Interacting with Its Receptor Model HER2-DIVMP

Temperature-Neutral Transient Receptor Potential Vanilloid-1 (TRPV1) Antagonist with Analgesic Efficacy

Novel blocker of the activation of the TRPV1 channel by capsaicin, inducing hypothermia involving tail-skin, vasodilation at thermoneutrality, decreasing body temperature

Selective adenosine kinase (AK) inhibitor

Negative control for A-192621

Novel potassium channel opener, more potent enantiomer

Novel potent and orally active adenosine kinase inhibitor

Novel adenosine A2A receptor (A2AR) antagonist

Multidrug Resistance (MDR) Modulator

Novel and selective H3 receptor antagonist

Selective nonimidazole H3 receptor inverse agonist

Nicotinic acetylcholine receptor agonist

Novel Bcl-XL antagonist

Multidrug Resistance (MDR) Modulator

Cannabinoid agonist; Analgesic

Selective H3 antagonist

Novel α4β2 neuronal nicotinic receptor positive allosteric modulator

Novel transient receptor potential type V1 receptor antagonist

Potent and selective AKT>Akt kinases inhibitor

Potent and selective α7 nAChR partial agonist

Potent CCK1 agonist

Negative control for A-745

Potent and selective cannabinoid CB2 receptor agonist

High affinity α2-adrenoceptor antagonist and selective 5-HT uptake inhibitor

Selective α7 nicotinic acetylcholine receptor (nAChR) agonist

Highly selective agonist of α4β2 subtype of neural nicotinic acetylcholine receptors

Potent and selective α4β2 nACh receptor agonist

Selective dopamine receptor D1 agonist

Inactive enantiomer of A-908292 with approximately 50-fold less activity against ACC2, also causing a similar reduction in glucose and triglycerides

Selective TRPV1 antagonist

Potent and selective histamine H4 receptor antagonist

Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist

Potent and selective histamine H4 receptor antagonist

Selective TRPV1 antagonist

Novel potent MDM2 degrader

Novel potent agonist and positive allosteric modulator (Ago-PAM) of δ-GABAARs

Ultrapotent in vivo-active serine hydrolase inhibitor

Novel selective Inhibitor for AAA (ATPase associated with diverse cellular activities) Proteins

Novel inhibitor of adaptor associated kinase 1 (AAK1), demonstrating improved activity against dengue virus both in vitro and in human primary dendritic cells and the unrelated Ebola virus

Novel selective dual inhibitor of Aurora/PLK, significantly inhibiting the development of the colon cancer growth and prolonging the median survival time

Photoswitchable Kv channel blocker

Novel inhibitor of the in vivo aggregation of Aβ1-42

Atypical antipsychotic, potently binging to D2 receptors and 5-HT2 receptors

Novel Trojan Horse Prodrug for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity

Novel Trojan Horse Prodrug for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity

Potent fluorescent agonist of the human A1 or A3 adenosine receptors, (dissociation constants: A1 and A3 receptors were approximately 50 and 10 nM, respectively)

Novel GHS-R1a biased ligand, acting as a Gαq/11 inverse agonist

Novel ligand of the dimerization interface of survivin monomers

Novel fluorescent highly potent agonist at the adenosine A3 receptor in both reporter gene (pEC50 = 8.48 ± 0.09) and internalization assays (pEC50 = 7.47 ± 0.11)

Novel fluorescent A3 adenosine receptor (A3‐AR) agonist

ABI-231 analogue, disrupting tubulin polymerization, promoting microtubule fragmentation, inhibiting cancer cell migration, overcoming paclitaxel resistance in a taxane-resistant PC-3/TxR model

Novel potent colchicine binding site inhibitor (CBSI) and tubulin inhibitor

Novel potent type II ABL/c-KIT dual kinase inhibitor

Novel potent and selective inhibitor of ABHD10 (IC50 value ~ 30 nM)

Peptide substrate for Abl Kinase (Abl protein tyrosine kinase), a partner in the gag-Abl fusion protein of the Abelson murine leukemia virus

Inhibitor of ribonucleotide reductase (RNR)

Novel cyanine-5 containing probe for cathepsin K, showing selective visualization in complex proteomes, and live cell imaging of a human osteosarcoma cell line

Natural TMPRSS2 inhibitor

Natural hACE2 inhibitor with strong affinity for the exopeptidase site of hACE2

Potent and selective histamine H3 receptor antagonist

Agonist of neural nicotinic acetylcholine receptors

Novel PARP inhibitor

Hghly selective antagonist for endothelin ET A receptor

Potent nicotinic acetylcholine receptor agonist

Orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction

Selective dopamine D3 receptor antagonist

Inhibitor of protein synthesis with potent activity against multidrug-resistant Gram-positive bacterial strains

Novel agonist of STING (stimulator of interferon genes) with enhanced binding to STING and cellular function

Novel potent and selective KOR antagonist, potentially stabilizing the bioactive conformation and enhancing its metabolic stability

Novel potent, nontoxic, and highly selective breast cancer resistance protein (BCRP) inhibitor

Novel blocker of HOX antisense intergenic RNA (HOTAIR) by abrogating the scaffold interaction with EZH2

Selective NPFF(1) receptor ligand

Novel potent, nontoxic, and highly selective breast cancer resistance protein (BCRP/ABCG2) inhibitor

Orally bioavailable M(1) muscarinic receptor allosteric agonist improving cognitive performance in an animal model

Novel inhibitor of Mycobacterium tuberculosis (Mtb) growth at acidic pH, killing Mtb by selectively depleting free thiols at acidic pH

Novel inhibitor of Mycobacterium tuberculosis (Mtb), selectively killing Mtb at acidic pH and potentiating the bactericidal activity of isoniazid, clofazimine, and diamide

Novel potent, nontoxic, and highly selective breast cancer resistance protein (BCRP) inhibitor

Prodrug of 4FGalNAz to label a variety of proteins in mammalian cells without perturbing endogenous glycosylation pathways and primarily act as a substrate for O-GlcNAc transferase (OGT)

Novel potent, nontoxic, and highly selective breast cancer resistance protein (BCRP) inhibitor

Novel benzodiazepine receptor partial inverse agonist