Novel novel anti-tuberculosis (TB) agent, possessing improved safety properties compared to bedaquiline

Metabolite of Telmisartan

Negative control for TH1760

Novel potent and selective NUDT15 inhibitor (MG IC50 = 35 nM), potentiating the anti-HCMV efficacy of ganciclovir

Negative control for THPP-1

Negative control for TP-040

Negative control for TP-238

Negative control for TP-004

Cell impermeant homolog of UCD38B, inhibitor of uPA (urokinase plasminogen activator)

Negative control for UCSF924

Negative control compound for UNC3866 which is a potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains

Negative control for EED inhibitor EED226

Negative control for UNC6852

Inactive control for VinSpinIn

Vesicular monoamine transporter-2 (VMAT2) inhibitor, with 15-​fold greater affinity than GZ-​793A

Metabolite of VX-740

Less active enantiomer of Elexacaftor

Natural microbial metabolite of isoflavone genistein, increasing the lifespan and improving the thermal and oxidative stress tolerance of C. elegans

Moderate alpha-l-fucosidase inhibitor

Inhibitor of Eukaryotic Translation; Antitumor Natural Product

Antitumor agent to be associated with negative regulation of Met endosomal signaling in renal cancer cells

Novel inhibitor of cholesterol transport proteins

Subtype-selective activator of K(Ca)2.1

Natural modulator of miRNA biogenesis, inhibiting the proliferation, migration, and invasion of hepatocellular carcinoma (HCC) cells

Novel potent inhibitor of the CREBBP/EP300 bromodomain, showing >100-fold selectivity over a representative member of the BET bromodomains, BRD4(1)

Inhibitor of VMAT-2, decreasing monamines into synaptic vesicles

Novel non-nucleoside reverse transcriptase inhibitor (NNRTI)

Natural inhibitor of hepatocyte ferroptosis, protecting against drug-induced liver injury

Natural inhibitor of ERK signaling pathways, inhibiting epithelial-mesenchymal transition via STAT3, showing the growth inhibition of HepG2, HeLa and MGC-803 cancer cell lines

Novel TNKS/2 inhibitor, competing with nicotinamide binding to tankyrases

Natural highly potent inhibitor of the serotonin transporter (SERT)

Novel BRD4 inhibitor, suppressing osteoclastogenesis and ovariectomized osteoporosis by blocking RANKL-mediated MAPK and NF-κB pathways

Antiviral activity against Varicella Zoster

Novel potent anti-malarial agent against multiple resistant strains of P. falciparum in vitro and show no cytotoxicity to mammalian cells

Catecholamine-depleting agent, actively against the 3 major monoamines in the CNS

Novel probe for mycobacterial and fungal carbonic anhydrase

Novel angiogenesis inhibitor, regulating endothelial cell fate and angiogenesis

Selective agonist of delta opioid receptor

Novel potassium channel opener

Inhibitor of ADP-induced platelet aggregation; anti-thrombotic

Potent and selective 5-HT2 serotonin receptor agonist

Novel profluorescent RAMOSUS3 (RMS3) probe with strigolactone-like bioactivity

Novel prodrug of the sigma (σ) ligand haloperidol metabolite II conjugated with the histone deacetylase (HDAC) inhibitor valproic acid, demonstrating antiangiogenic activity

Potent antagonist of GluN2B-NMDA receptors (Ki = 5.8 nM), inhibiting ion flux in two-electrode voltage clamp experiments (IC50 = 223 nM)

Negative control for RSL3

Building Block

Novel water-sensitive probe, demonstrating superior sensitivity for detecting modulation of water microsolvation, structural conformation during oligomer formation and 5FUrd binding to both wild type and mutant SOD1

Orphan nuclear receptor DAF-12 ligand, inhibiting the dauer-promoting activity of DAF-12

Novel lysophosphatidic acid receptor 3 (LPA3) agonist

Novel anti-thrombosis agent, orally inhibiting venous thrombosis and arterial thrombosis in vivo, showing no bleeding risk

Quantity (mg or Unit) Unit Price ($/mg or $/Unit) Final Price 100 $44.55 Total: $4,455.00 50 $51.48 Total: $2,574.00 25 $60.39 Total: $1,509.75 10 $71.28 Total: $712.80 5 $84.15 Total: $420.75

Estrogen receptor α (ERα) ligand as potent antiestrogen; Metabolite of tamoxifen

Promising therapeutic tool for AMPH-induced addiction, reducing the oxidative stress, attenuating evoked (MA and heat HA) and spontaneous pain (FST) phenotypes, and all phases of morphine-induced behavioral locomotor sensitization in mice

Novel Covalent Inhibitor of Ca -Bound S100B

5-HT2 receptor agonist, inhibiting TNF-α-mediated proinflammatory signaling cascades and inflammation via 5-HT2A receptor activation and preventing the development of, and inflammation associated with, acute allergic asthma

Selective serotonin reuptake inhibitor

R-Enantiomer of folcisteine, a plant growth regulator

Competitive Specific Inhibitor of sphingosine kinase 2 (SK2)

Precursor for (R)-[N-Methyl-11C-]PK11195

Inhibitor of dopamine beta-hydroxylase

More active R diastereomer of Pam2Cys, acting as a potent TLR2 agonist

Selective Dopamine D3 Receptor Antagonist

Enhancer of memory function

More active enantiomer of praziquantel as potent anthelmintic

Elongation factor P (EF-P) fuction modifier

Novel σ Receptor Agonist with Neuroprotective Effect

Novel potent orally available allosteric TSH receptor (TSHR) agonist

The First Selective Orthosteric GluK3 Antagonist

Natural flavonoid from the stem bark of Bolusanthus speciosus

Potent beta-adrenoreceptor antagonist

Potent and selective inhibitor of PI 3-kinase ß (PI3-Kß)

Less active enantimer of Bambuterol

PET precursor for NNC112

Selective kynurenine aminotransferase 2 (KAT2) inhibitor

S-Enantiomer of folcisteine, a plant growth regulator

Selective mGlu5 positive allosteric modulator (PAM)

mGlu5 PAM, displaying intrinsic agonist activity

Novel allosteric Sphingosine kinase 1 (SK1) inhibitor

Novel bacterial DNA gyrase inhibitor, exhibiting antimicrobial activity and inhibiting bacterial cell division

More active enantiomer of NBP; Neuroprotective agent used clinically in the acute phase of ischemic stroke, improving functional recovery and promoting angiogenesis and collateral vessel circulation

Potent D1 dopamine ligand

Inhibitor of angiogenesis and growth of B-cell neoplasias, inducing complete regressions of Burkitt's lymphoma cell tumors

Novel potent inhibitor of Shiga toxin (STX) cytotoxicity

Novel Potent Antagonist of the Human A 2B Adenosine Receptor

Novel Potent Antagonist of the Human A 2B Adenosine Receptor

Novel Antimicrobial Peptide with Repeating Unit against Multidrug-Resistant Bacteria

Novel Antimicrobial Peptide with Repeating Unit against Multidrug-Resistant Bacteria

Novel ligand of the mouse orphan odorant receptor Olfr288

Novel highly potent dual NOP/mu receptor peptide agonist, exerting antitussive effects in an in vivo model of cough

Short-duration κ opioid receptor antagonist with weak KOR agonist activity

Novel α-Conotoxin LvIA Analogue, highly selectively trgeting α3β2 nicotinic acetylcholine receptors with >2000-fold higher selectivity than LvIA

Novel inhibitor of the biosynthesis of DNA, RNA and proteins; Antimicrobial agent

Novel inhibitor of the biosynthesis of DNA, RNA and proteins; Antimicrobial agent

Novel potent ferroptosis inhibitor

Anti-androgenic, Antimicrobial, and anticancer agent

Inhibitor of the Cdc42-PBD interaction, blocking the association of Cdc42 with the PBD

Long chain dithiol for self-assembled monolayers (SAMs) in sensors

Novel Myc-Max-specific inhibitor

Donor of formyl groups in anabolism used as a substrate in formyltransferase reactions, which is important in purine biosynthesis

Selective activator of TREK-2 channels, stimulating DRG c-fiber nociceptor K2P currents and limiting calcium influx

Cellular antiproliferative agent, inhibiting BrdU incorporation acrossing multiple cell lines with varying potency

Potent inhibitor of both mouse and human 11β-HSD1

Novel potent and selective inhibitor of 11ß-hydroxysteroid dehydrogenase type 1 enzyme

Aß40 fibril disrupter

Metabolite of Nevirapine

Novel regulator of plant growth and immunity, promoting flower and tuber development but prevents induction of JA signaling, plant defense or both

Potent highly active irreversible inhibitor of myeloperoxidase (MPO)

Antagonist of EpETrE-induced relaxation of vascular smooth muscle

The First Ligand Targeting the Dimerization Interface of the 14-3-3ζ Adapter Protein

Natural inhibitor of TNF-α-induced tissue factor (TF) expression via the PI3K/AKT/ NF-κB axis in human umbilical vein endothelial cells

Inhibitor of monocyte/macrophage infiltration and the expressions of intercellular adhesion molecules under hypoxia

Potent clickable photoaffinity probe, targeting gamma-secretase

Notch-sparing

Major metabolite of eicosapentaenoic acid (EPA)

Novel potent 17β-HSD12 activator

Potent HSP90 inhibitor

Acetylcholinesterase (AChE) inhibitor

Irreversible inhibitor of PI3K and mTOR

Novel potent inhibitor of 17ß-hydroxysteroid dehydrogenase type 2 (17ß-HSD2)

Novel inhibitor of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), being highly selective over 17β-HSD2

Novel Neuroprotective GSK-3β Inhibitor, highly selectively inhibiting HIV-1; The second generation derivative of 6BIO

Highly potent inhibitor of Wnt/βcatenin signaling in melanoma cells, coordinately inhibiting cell proliferation and disrupts expression of Microphthalmia Associated Transcription Factor isoform M, also inhibiting NEDD4-1

Strong growth inhibitor as an antimetabolite

Reporter molecule functionalized at the anomeric position, exhibiting robust labeling over background with negligible amounts of nonspecific chemical labeling in cell lysates

Reporter molecule functionalized at the anomeric position, exhibiting robust labeling over background with negligible amounts of nonspecific chemical labeling in cell lysates

Building Block

Building Block

Building Block

The first organic NO2-containing molecule isolated from plants, stimulating the soluble guanylate cyclase-cGMP pathway

inactive isomeric impurity of Alphacalcidol

Novel inhibitor of thioredoxin reductase (TrxR)

Novel potent antiangiogenic agent, binding to VEGFR2, significantly reducing neovascularization in both ex vivo and in vivo angiogenic assays without affecting the proliferation of endothelial cells

Natural Inhibitor for FcεRI expression on mast cell from Verbasucum thapsus L

Inhibitor of SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux

Concentration- and time-dependent inhibitor of the growth of NSCLC cells inducing apoptosis

Stimulator of the central nervous system, decreasing the 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in brain

Novel Versatile Probe for Interrogating Histone Benzoylation and Interactions in Living Cells

Oxysterol agonist of the liver X receptor

Novel Selective LXRβ Agonist

Novel selective inhibitor of EGFR kinase, leading to inactivation of PI3K/AKT/mTOR and Ras-Raf-MEK-ERK signal pathways

Novel GPR88 Agonist

Novel potent activator of both human and mouse TLR4-NF-κB reporter cells and primary cells, inducing serum anti-HA and anti-NA IgG1 levels

Metabotropic Glutamate Receptor 5-selective Negative Allosteric Modulator

Lipid mediator, regulates neuronal apoptosis in traumatic brain injury (TBI)

Site BI- selective synergistic activator of PKA I

Inhibitor of cellular glycosylation; Analytical standard

Endogenous superagonist of transient receptor potential melastatin 2 (TRPM2)

Novel potent natural STAT3 signaling inhibitor from Polygonum cuspidatum, inhibiting cell growth and inducing apoptosis of HCC cells and HCC Cancer stem cells.

Potent and selective PAR2 receptor agonist

Non-hydrolyzable ATP analog, acting as an effective and selective NTPDase2 inhibitor

Potent and selective JNK inhibitor; Analogue of SP600125 with improved potency and selectivity

Potent human sex hormone binding globulin (SHBG) ligand

Inhibitor of the Cdc42-PBD interaction, blocking the association of Cdc42 with the PBD

Antiatherosclerotic, antihyperlipidemic, antiinflammatory, antifungal, antiviral and antineoplastic

Novel inhibitor of thioredoxin reductase (TrxR)

Novel inhibitor of soluble epoxide hydrolase (sEH), showing good solubility, microsomal stability, and selectivity for sEH

Novel double photocaged cathepsin B activity-based probe for monitoring the light-activation by the blue fluorescence of 7-diethylamino-4-hydroxymethyl-coumarin (DEACM) and simultaneously probe the activity of cathepsin B through the green fluorescence of

Highly selective and relatively potent group II metabotropic glutamate receptor agonist

Novel pro-angiogenic agent, potently promoting proliferation, migration, invasion and tube formation of human umbilical vein VECs (HUVECs) in vitro

Novel, active, and less toxic anti-tuberculosis (anti-TB) agent

Novel STING Agonist

Inhibitor of Beta_amyloid>amyloid β-mediated cellular toxicity

Natural inhibitor of respiratory syncytial virus entry and infection by blocking the interaction of the viral fusion protein with the cell membrane.

Inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1)

Metabolite of thyroid hormones (thyroxine and triiodo-L-thyronine)

Useful pharmaceutical building block

Natural potent, selective, and efficacious inhibitor of SHP2, suppressing A549 cell proliferation (IC 50 =10.79±0.14μM), invasion and inducing cell apoptosis through SHP2/ERK1/2 and SHP2/AKT pathways

Natural inducer of DNA damage, cell cycle arrest, apoptosis, and autophagy in macrophages

SL0101 analog, acting as a specific inhibitor of p90 ribosomal S6 kinase (RSK), being approximately 2-fold more potent at inhibiting MCF-7 cell proliferation compared to SL0101 and preferentially decreased MCF-7 cell growth, as compared to the growth of t

Endogenous inhibitory androstane neurosteroid and weak androgen, and a major metabolite of dihydrotestosterone (DHT); Potent positive allosteric modulator of the GABAA receptor

Neuroprotective and proliferative agent with significantly higher stimulatory effect than that of allopregnanolone

Tyrosine drivative, being a useful probe to study the role of redox active tyrosines in enzymes

Potent endogenous estrogen

Putative natural allosteric modulator of human Hsp90α conformational dynamics by allosteric ligand interaction at the C-terminal domain site 2

Prodrug of the glycolysis inhibitor 3-bromopyruvate (3-BrPA) which targets hexokinase II (HK2) and GAPDH

The first-in-class triple topoisomerase I/topoisomerase II/tubulin inhibitor

Novel inhibitor of 3C-like protease (3CLpro) of MERS-CoV and severe acute respiratory syndrome coronavirus (SARS-CoV)

Cell-permeable sialic acid analog, deacetylating intracellularly to a sialyltransferase inhibitor, abolishing SLex expression on HL-60 cells, reducing E-selectin and P-selectin binding and preventing metastasis formation in a mouse lung metastasis model

Novel anti-Parkinson agent, targeting the D2R

Biological Active Reagents

Novel mammalian targeting potent inhibitor of rapamycin (mTOR) activation

Novel potent apoptotic inducer, inducing G2-M cell cycle arrest, blocking tubulin polymerization

Novel plant immunoregulator, being effective in delaying senescence in detached leaves while having low interactions with the cytokinin pathway, upregulating genes involved in processes associated with plant innate immunity such as cell wall remodeling an

Major tryptophan catabolite of the kynurenine pathway, showing antiparasitic activity

Metabolite in the kynurenine pathway, the major route of tryptophan degradation in mammals

Novel Orally Active Antimalarials Targeting Plasmodium falciparum

Novel GATA4-NKX2-5 transcriptional synergy activator, significantly enhancing the mechanical stretch-stimulated increase of the ANP mRNA levels

Potent, ATP-competitive and reversible inhibitor of Akt1/2/3-as1/2 without inhibiting Akt1/2/3-wt

Metabotropic glutamate I (mGlu1) receptor antagonist

Novel plant immunoregulator, being effective in delaying senescence in detached leaves while having low interactions with the cytokinin pathway, upregulating genes involved in processes associated with plant innate immunity such as cell wall remodeling an

Antiatherosclerotic, antihyperlipidemic, antiinflammatory, antifungal, antiviral and antineoplastic

Estradiol derivative, showing antioxidant activity

Novel anticancer pan-JAK inhibitor against A2058 human melanoma cells, selective and potent inhibitor of JAK1 and TYK2

Novel potent and selective anti-Trypanosoma cruzi agent

Natural inhibitor of RORγt, ittenuating Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation

Useful building block and intermediate

Potent antagonist of the Pseudomonas aeruginosa Transcriptional Regulator PqsR

Novel potent and selective triple reuptake inhibitor (TRI)

5HT(1B/1D) receptor partial agonist, inhibiting electrically induced plasma extravasation, blocking neurogenic plasma protein extravasation, inhibiting release of calcitonin gene-related peptide

Antioxidant, significantly increased gene expression of the anti-aging factor, SIRT1, stimulating the expression of skin growth factor and inhibiting pro-inflammatory genes