Novel potent and selective multidrug resistance-associated protein 1 (MRP1, ABCC1) modulator

Novel potent and specific inhibitor of janus kinase 2 (JAK2)

Novel metabolic oligosaccharide engineering (MOE) reagent, being an efficient chemical tool to probe protein glycosylation

Novel metabolic oligosaccharide engineering (MOE) reagent, being an efficient chemical tool to probe protein glycosylation

Novel, cell-permeable, potent O-GlcNAc transferase (OGT) inhibitor

Novel Selective, irreversible, and Rapid Cell-Permeable Inhibitor of Human Caspase-3

Novel highly potent and selective acetyl-CoA carboxylase 1 (ACC1) inhibitor (hACC1: IC 50 =0.58nM, hACC2: IC 50 >10000nM)

Novel Acetyl-CoA Carboxylase 2 (ACC2) Selective Inhibitor, Improving Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways

Highly photodurable and blue-laser excitable fluorescent amino acid. acting as a highly fluorescent probe after being incorporated into specific positions of various antibodies, receptors, and enzymes

Selective Caspase-3 inhibitor

Analgesic, antipyretic, and anti-inflammatory agent

Novel Inhibitor of Cellulose Synthesis

Antipsychotic, targeting the dopamine D2 receptor

Novel potent and selective LpxC inhibitor

Novel Inhibitor of BRD4-Driven Nucleoporin NUP210 Expression, Attenuating Colorectal Cancer Growth

Novel potent activator of pan-AMPK, enhancing AMPK phosphorylation by upstream kinase LKB1 and protecting AMPK complex against dephosphorylation by PP2C

Novel selective HDAC6 inhibitor, showing 260-fold selectivity towards HDAC6 vs other HDACs

Novel selective USP8 inhibitor (USP8 IC50 2.1 μM; USP7 >50μM)

Novel potent inhibitor of the MDM2-p53 interaction

Potential antidepressant and anti-Parkinson agent

Potential antidepressant and anti-Parkinson agent

Selective inhibitor of ADAMTS-5 (A disintegrin and metalloproteinase with thrombospondin motifs 5 or aggrecanase-2)

Novel Hsp40-Hsp70 chaperone complex inhibitor, inhibiting the Hsp40-stimulated ATPase activity of the Hsp70 chaperone, with a K i of ~10 μM

Novel inhibitor of ClpXP complexes, causing extremely rapid dissociation of ClpXP complexes, preventing ClpX rebinding following spontaneous dissociation

Novel sheddase inhibitor, inhibiting the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity

Antidepressant and anxiolytic agent, binding to peripheral-type benzodiazepine receptors that interact allosterically with GABA receptors as an agonist to produce inhibitory effects

Novel Potent Mutant p53 Rescuing Agent

Novel antibiotic adjuvant, exhibiting as high as 4096-fold potentiation of multiple classes of antibiotics toward critical Gram-negative superbugs

Novel antibiotic adjuvant, exhibiting as high as 4096-fold potentiation of multiple classes of antibiotics toward critical Gram-negative superbugs

Novel soluble analog of FiVe1

Poly(ADP-Ribose) Glycohydrolase (PARG) inhibitor

Active iron-chelating metabolite of dexrazoxane

Nonselective agonist of all adrenergic receptors, including the major subtypes alpha1, alpha2, ß1, ß2, and ß3

Novel Inhibitor of EGF-EGFR Interactions

Inhibitor of semen-derived amyloid fibril formation, blocking fibril-mediated enhancement of HIV-1 infection

Novel PDE10 inhibitor, reducing oncogenic β-catenin, suppressing TCF/LEF transcription

The first selective dual-target inhibitor of ERK1 and ERK5

Novel Nonsteroidal Negative Allosteric Modulator of Follicle-Stimulating Hormone Receptor (FSHR)

Novel Nonsteroidal Negative Allosteric Modulator of Follicle-Stimulating Hormone Receptor (FSHR)

Novel inhibitor of hFSHR (104 nM) and hLHR (314 nM), showing no activity with hTSHR at 30 μM

Novel inhibitor of Jun kinase activity and cell death through induced expression of heat shock protein 70

Bacterial iron chelating agent as a siderophore and an Escherichia coli metabolite

Novel inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1)

Potent antagonist of P2X3 and P2X2/3

Novel CC chemokine receptor 4 (CCR4) antagonist

Quantity (mg or Unit) Unit Price ($/mg or $/Unit) Final Price 100 $36.45 Total: $3,645.00 50 $42.12 Total: $2,106.00 25 $49.41 Total: $1,235.25 10 $58.32 Total: $583.20 5 $68.85 Total: $344.25

Natural Potent Hepatocarcinogen

Staurosporine analog, acting as a Jak3-specific inhibitor

Probe used for Early detection of Alzheimer's disease

pan-Cyclin dependent kinase (CDK) inhibitor

Potent inhibitor of tyrosine kinases; Direct and selective inhibitor of photosynthetic PEP carboxylase; Inhibitor of PDGFR-β, Flk-1, and angiogenesis

Novel capsaicinoid-based soft drug, attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability

Inhibitor of the glycinamide ribonucleotide formyltransferase (GARFT)

Novel potent FKBP12 ligand

Novel potent FKBP12 ligand

Anticancer agent with antioxidant and chemopreventive properties

Inhibitor of NS2B-NS3 proteases of the Dengue virus serotypes 2 and 3

Novel inducer of anti-tumor immunity, converting tumors into in situ autologous vaccines

Novel methionine adenosyltransferase 2A (MATA2 ) inhibitor

Novel potent and selective RARα inhibitor

Retinoic Acid Receptor α Subtype Specific Agonist

Novel potent and specific RARα antagonist

Inhibitor of the basal proton conductance of UCP1; Retinoid, displaying a nonspecific stimulation of NADH oxidation in control mitochondria

alpha Adrenoceptor agonist for the treatment of neuropathic pain

Inhibitor of tryptophan hydroxylase activation

Novel Keap1-Nrf2 pathway activator by inhibiting the Keap1 protein

Novel Keap1-Nrf2 pathway activator by inhibiting the Keap1 protein

Natural inhibitor of Xanthomonas oryzae growth, against rice pathogens

Microtubule>Tubulin polymerization inhibitor with marked antitumor activities

Natural selective inhibitor of IKKα/β by covalently binding a conserved cysteine

Novel quorum sensing (QS) signaling molecule produced by Staphylococcus aureusagr type IV

Novel FMS-like tyrosine kinase 3 (FLT3) inhibitor, showing improved anti-leukemic efficacy in FLT3-ITD-positive AML cells, specifically inhibiting cell growth and apoptotic death, down-regulating DNA repair genes involved in homologous recombination and n

Novel inhibitor of long chain fatty acid elongase 6 (ELOVL6)

Novel β3-Adrenoceptor agonist, reducing body fat in obese beagles

Novel protein kinase C (PKC) activator, preferentially binding to the novel PKC isoforms PKCδ and PKC∈, stimulated a striking preferential redistribution of PKC∈ to the plasma membrane relative to PKCα, inducing major changes in cytoskeletal reorganizatio

Novel antiproliferative agent

Novel and potent PAK1 (p21-activated kinase 1) inhibitor, suppressing the proliferation of human gastric cancer cells significantly by downregulation of PAK1-NFκB-CyclinB1 pathway

Novel Inhibitor of EGF-EGFR Interactions

Novel inhibitor of p38 MAP kinase

Novel S1P1 agonist

Novel potent and selective aldo-keto reductase 1C3 inhibitor, displaying selectivity for AKR1C3 over other AKR1C enzymes and COX

Cell-permeable Akt1/2 inhibitor with improved solubility and Ak2 selectivity

Potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist

Non-steroidal selective modulator for the glucocorticoid receptor (GR)

Novel HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C

Novel anti-MRSA antibacterial agent, targeting infections caused by Gram-positive bacteria

α-Linolenic acid-Valproic acid conjugate, not only modulating microglia polarization, but also counteracting neurodegeneration and demyelination and induce oligodendrocyte precursor cell differentiation, by acting on multiple biochemical and epigenetic pa

Potent analgesic, psychotomimetic or hallucinogen, and morphine or opioid antagonist

Potent DNA gyrase inhibitor

Natural antitumor agent, inducing caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway

Novel nucleoside phytotoxin

Neuromuscular blocking (NMB) agent

Novel activator of ALDH3A1

Potent and specific covalent inhibitor of aldehyde dehydrogenases

Novel ALDH inhibitor, inhibiting ALDH3A1 activity in SCC4 HNSCC xenografts

Prodrug of the anthracycline antibiotic doxorubicin, binding selectively to the cysteine-34 position of albumin via its maleimide moiety, inhibiting DNA synthesis, and inducing apoptosis

Potent and selective L1196M ALK and ROS1 dual inhibitor

ALK-001 is a vitamin A analog potentially for the treatment of Stargardt’s disease.

Clickable PPARγ inhibitor

Novel Enrichable and MS-Cleavable Cross-linker to Define Protein-Protein Interactions by Mass Spectrometry

Potent and selective triple reuptake inhibitor

Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor

Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor

Novel allosteric modulator to control endogenous G protein-coupled receptors with light

Natural chemical suppressor of mlo-mediated resistance in monocotyledonous barley (Hordeum vulgare) and dicotyledonous Arabidopsis thaliana

Antioxidant, attenuating collagen-induced arthritis via attenuation of oxidative stress secondary to modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 pathways

Novel potent type I positive allosteric modulator (PAM) of human α7 nAChR

Highly potent, orally effective, and metabolically stable allosteric 5-LOX Inhibitor

Novel JAK2/STAT5 inhibitor

Novel inhibitor of JAK2 and STAT5 phosphorylation in response to interleukin-3 without altering STAT5 mobility in SDS-PAGE

Psychedelic, an analog of mescaline

Novel potent inhibitor of the SARS-CoV-2 Mpro, revealing a pronounced lung tropism and suitability for administration by the inhalative route

One of the most effective antioxidants, being involved in the cellular antioxidant system

Neurotransmitter; stimulating nicotinic receptors

Novel modulator of collagen synthesis and matrix metalloproteinases (MMPs) expression levels, boosting collagen synthesis and reducing MMPs expression levels in human fibroblasts without cytotoxicity

Prodrug of Vitamin E, modulating atherosclerotic and inflammatory events more efficiently than the unphosphorylated alpha-tocopherol

Specific inhibitor of aldose reductase

Novel potent and selective oxytocin receptor antagonist

Novel selective dual inhibitor of Cdk1/cyclin B and GSK-3β

Inhibitor of HSP90, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction

Peripherally acting µ-opioid antagonist

Novel lipoxin A4 receptor/formyl peptide receptor 2 (ALX/FPR2) antagonist

Prodrug of ALX5407, a selective non-transportable inhibitor of the glycine transporter GlyT1

Potent GlyT-2 antagonist

Novel potent, selective, and orally bioavailable PI3Kdelta inhibitor

Novel Cannabinoid Receptor CB2 antagonist

The first covalent hCB2 antagonist/inverse agonist

Novel potent, selective, and orally bioavailable PI3Kdelta inhibitor

Novel GPR40 agonist with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837

Potent in vitro and in vivo inhibitor of fatty acid amide hydrolase (FAAH)

Potent FFA1 (GPR40) agonist, inhibiting insulin secretion from isolated pancreatic islets and reducing blood glucose levels

Novel highly potent inhibitor of human alpha/beta hydrolase domain 6 (hABHD6)

Reversible cholinesterase inhibitor used in the management of myasthenia gravis

Antibiotic against Serratia sp. ATCC 39006 (S39006) strain

Downregulator of genes associated with the translation machinery and fatty acid biosynthesis in Serratia, increasing expression of genes related to the uptake of L-proline after RNA-Seq of S39006 to be treated

Novel inducer of inactivation of eIF2-alpha by phosphorylating serine residue 51 in a dose- and time-dependent manner

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Novel modulator of autophagy activity, triggering autophagy in an Atg5-dependent manner, recruiting Atg16 to the pre-autophagosomal site and causing LC3 lipidation

Natural thrombin (E.C. 3.4.21.5) inhibitor, suppressing melanin synthesis, regulating the ATM/ATR signaling pathway and the Skp2-p27 axis in human colon cancer cells

Novel PDE10 antagonist

Novel transient receptor potential type V1 (TRPV1) receptor antagonist

Novel disrupter of glucokinase-glucokinase regulatory protein (GK-GKRP) binding, inducing GK translocation from the nucleus to the cytoplasm in rats and blood glucose reduction in mice

Novel glucokinase activator, decreasing fasting and postprandial glycaemia

Novel selective IRE1α inhibitor

Potent and selective TRPV1 antagonist

Novel potent DPP-IV inhibitor

Novel potent and selective inhibitor of c-Kit

Sotorasib racemate (Compound A) is an orally active racemate of Sotorasib, a covalent inhibitor of KRAS G12C mutant which induces adaptive feedback activation of MAPK pathway. Sotorasib racemate also exerts inhibitor activity against KRAS G12C induced cancer and can be applied to cancer research.

Novel Disrupter of Glucokinase−Glucokinase Regulatory Protein (GK−GKRP) Binding

Novel highly specific phosphodiesterase 10A (PDE10A) ligand with good uptake in the striatum

Vanilloid receptor TRPV1 antagonist

Novel vanilloid receptor TRPV1 modulator

Novel vanilloid receptor TRPV1 modulator

Specific transient receptor potential ankyrin 1 (TRPA1) antagonist

Quantity (mg or Unit) Unit Price ($/mg or $/Unit) Final Price 100 $15.75 Total: $1,575.00 50 $18.20 Total: $910.00 25 $21.35 Total: $533.75 10 $25.20 Total: $252.00 5 $29.75 Total: $148.75

Cysteine trapping agent, protecting cysteines exposed to the aqueous environment from subsequently added mal-PEG

Radiation-protective agent, causing splenic vasodilation and blocking autonomic ganglia

NSAID (non-steroidal anti-inflammatory drug) and non selective COX inhibitor

Immunomodulator

Inhibitor of the re-uptake of norepinephrine and serotonin, inhibiting N-methyl-D-aspartate (NMDA) receptors

L-type calcium channel blocker

Anthelmintic agent against infections with the human hookworm

Light-activated DNA, RNA crosslinking agent

Potent A1/A2A adenosine receptor agonist, protecting against myocardial infarction

The most potent AMPA stabilizer

Novel rapid and specific inhibitor of electrophile-sensitive DEAD-box proteins with high selectivity over the wild-type enzyme

Potent allosteric activator of AMPK

Potent allosteric activator of the AMPK

Novel agonist of AMPK signaling

Novel Metallo-β-lactamase Inhibitor

Novel potent inhibitor of peroxiredoxin I (PrxI), increasing cellular ROS, leading to the activation of both mitochondria- and apoptosis signal-regulated kinase-1-mediated signaling pathways

Novel small molecule prodrug for use with SEAKER cells, exhibiting enhanced anticancer activity

Novel inhibitor of the replication of a disease-causing polyomavirus in cell culture

DNA polymerase lambda and beta inhibitor

Novel Anti-Wolbachia Agent with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

Novel Neuraminidase (NA) inhibitor

Novel potent and selective leucyl-tRNA synthetase inhibitor

Inhibitor of TLR2-, TLR3-, TLR4- and TLR5-mediated TNF-α, IL-1β and IL-6

Novel anti-filariasis agent, being effective in killing Brugia malayi, B. pahangi, and Litomosoides sigmodontis worms

Anticholinergic agent

Novel Potent Anticonvulsant Agent with In Vitro Neuroprotection

Novel anticancer agent against metastatic Castration resistance and neuroendocrine variant prostate cancers (mCRPC/NEPC), exhibiting synergistic anticancer effect in combination with standard therapy docetaxel and cabazitaxel in mCRPC/NEPC, upregulating H

Novel angiogenesis agent, showing better efficacy than salidroside in enhancing the accumulation of the HIF-1α protein and stimulating the paracrine functions of skeletal muscle cells, significantly increasing the angiogenic potential of vascular endothel

Peptide hormone that causes vasoconstriction and an increase in blood pressure

Novel inducer of autophagic cell death through regulating PI3 kinase class III/beclin 1/Atg-related proteins in cisplatin-resistant CAR human oral cancer cells

Novel activator of nuclear factor-erythroid-related factor 2 (Nrf-2)

Novel potent DYRK1A Kinase Inhibitor

Novel Potent and Selective DYRK1 Kinase Inhibitor

Natural inhibitor of NADH:ubiquinone oxidoreductase

Antimitotic antibiotic with antitumor, antiprotozoal, and antifungal activities

Novel Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae

Novel Broad-Spectrum Serine β-Lactamase Inhibitor, Strongly Potentiating Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii

Novel anti-AD agent, integrating Aβ-interacting and metal-binding fragments in a single molecular framework, exhibiting significant antioxidant activity and metal chelating ability, and also rescuing neuroblastoma N2A cells from Cu -induced Aβ neurotoxici

Novel multitarget directed anti-Alzheimer agent, showing an IC 50 value of 0.56 ± 0.02 μM for AChE and an IC 50 value of 1.17 ± 0.09 μM for BuChE

Novel highly potent orally bioavailable antiallergic agent, effectively suppressing mast cell degranulation in a dose-dependent manner (IC50, 2.54 nM for RBL-2H3 cells; 48.28 nM for peritoneal mast cells (PMCs))

Novel dose-dependent antiangiogenic agent

Analogue of the marine sponge natural product oroidin, suppresses biofilm formation and enhancing control of copper-resistant Xanthomonas euvesicatoria on pepper

Novel Potent and Nontoxic Antibiotic Adjuvant

Novel anticancer agent, showing most significant anti-cancer activity against prostate cancer cells with IC50 values of 8.8 µM and 9.5 µM in PC-3 and DU-145 cells, respectively

Novel covalent anti-cancer toxin, targeting β-tubulin and covalently modifyng Cys239 within the colchicine binding site