Cat. No. | Product name | CAS No. |
DC22551 |
DFMTI
A potent, selective, brain penetrant and orally active mGluR1 antagonist with 4.3 nM and 3.6 nM for huam and rat mGluR1, respectively. |
864864-86-8 |
DC22895 |
VU0477573
A potent, selective, brain penetrant partial negative allosteric modulator of mGlu5 receptor with Ki of 14 nM, Ca assay IC50 of 32 nM. |
1946021-40-4 |
DC22964 |
PQ-10
Featured
A potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM. |
927691-21-2 |
DC23695 |
PF-05085727
A potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11. |
1415637-72-7 |
DC22920 |
AMN 082 dihydrochloride
A potent, selective, brain penetrant, orally acitve mGluR7 allosteric agonist that inhibits forskolin-stimulated cAMP accumulation in mGluR7b CHO cells with EC50 of 64±32 nM. |
97075-46-2 |
DC23640 |
ASP2535
A potent, selective, brain permeable, orally available glycine transporter-1 (GlyT1) inhibitor with IC50 of 92 nM (rat GlyT1), 50-fold selectivity over GlyT2. |
374886-51-8 |
DC20549 |
SHP2 inhibitor 11a-1
A potent, selective, cell active SHP2 inhibitor with IC50 of 200 nM, displays >5-fold selectivity against 20 other mammalian PTPs. |
1620746-09-9 |
DC22877 |
CPI703
A potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.47 uM for CBP. |
1904649-00-8 |
DC25052 |
Src I338G-IN-3g
A potent, selective, cell-permeable I338G v-Src inhibitor with IC50 of 430 nM, shows no inhibition of wild-type v-Src at 300 uM. |
206991-94-8 |
DC21474 |
PF-04781340
A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability. |
1648726-56-0 |
DC22708 |
VU 0255035
A potent, selective, CNS penetrant and competitive orthosteric antagonist of M1 mAChR with IC50 of 132 nM, >75-fold selectivity over M2-M5. |
1135243-19-4 |
DC22667 |
mGlu5 PAM 4k
A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM. |
1382782-16-2 |
DC22684 |
JNJ-46778212
Featured
A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM. |
1363281-27-9 |
DC22730 |
JNJ-42253432
A potent, selective, CNS-penetrant P2X7 antagonist with pKi of 9.1 and 7.9 for rat and huamn P2X7 channel, respectively. |
1428327-35-8 |
DC22903 |
SW-106
Featured
SW106 is a potent, selective, competitive PTH/PTH-related peptide receptor (PPR) antagonist with IC50 of 0.99 uM. |
1027921-53-4 |
DC23069 |
KRAS G12C inhibitor 1
A potent, selective, covalent KRAS G12C inhibitor that selectively inhibit KRAS G12C-dependent signaling and cancer cell growth at sub-micromolar concentrations.. |
1698023-15-2 |
DC21442 |
ONO 2050297
A potent, selective, dual CysLT1 and CysLT2 antagonist with IC50 of 17 and 0.87 nM, respectively.. |
847655-65-6 |
DC20736 |
AZD 9272
A potent, selective, highly CNS-penetrant and orally available mGluR5 negative allosteric modulator Kd of 2.8 nM. |
327056-26-8 |
DC20723 |
AZD 2066
A potent, selective, highly CNS-penetrant mGluR5 antagonist. |
934282-55-0 |
DC22679 |
CM 572
A potent, selective, irreversible sigma-2 receptor partial agonist with Ki of 14.6 nM, >700-fold selectivity over sigma-1 receptors. |
1121932-91-9 |
DC23412 |
BMS-955829
A potent, selective, low glutamate fold shift (2.4) mGluR5 positive allosteric modulator with EC50 of 2.6 nM, without inherent mGluR5 agonist activity (EC50>30 uM). |
1375751-08-8 |
DC22804 |
CMPD-1
A potent, selective, non-ATP-competitive inhibitor of p38α-mediated MK2a phosphorylation with apparent Ki of 330 nM. |
41179-33-3 |