| DC66223 |
11-10-8
Featured
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11-10-8 is an ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for mRNA delivery in vivo.1 LNPs containing 11-10-8 and encapsulating mRNA encoding the Cas9 nuclease and small-guide RNA (sgRNA) targeting transthyretin (TTR), a thyroid hormone carrier protein, decrease serum levels of TTR in mice. LNPs containing 11-10-8 and encapsulating mRNA encoding human fibroblast growth factor 21 (hFGF21) increase serum levels of hFGF21, decrease body and liver weights, and reduce the liver steatosis score in a mouse model of obesity induced by a high-fat diet. |
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| DC60591 |
Fmoc-Gly-Gly-OH
Featured
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Fmoc-Gly-Gly-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC66224 |
DOPE-PEG-CY7
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.
Cy7 emits at 750 nm and has a maximum absorption peak at about 773 nm. Cyanine dye is often used in biomolecular labeling, fluorescence imaging and other fluorescent biological analysis, and Cy7-labeled PEG derivatives can be used to track biomolecules due to their strong red light fluorescence. |
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| DC66225 |
DOPE-PEG-N3
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66226 |
DOPE-PEG-NBD
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66227 |
DOPE-PEG-Alkyne
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66228 |
DOPE-PEG-Glucose
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66229 |
DOPE-PEG-DOTA
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66230 |
DOPE-PEG-PEI
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66232 |
DOPE-PEG-Mannose
Featured
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DMPE-PEG, a synthetic lipid, possesses unique properties and finds extensive applications as liposomes. Firstly, DMPE-PEG exhibits excellent biocompatibility and solubility, allowing for its stable presence and efficient absorption and metabolism in vivo. Additionally, DMPE-PEG possesses good surface activity, aiding in the stabilization of liposome structures and enhancing their stability.
Moreover, DMPE-PEG displays highly tunable monolayer properties, enabling the modulation of liposome's charge, surface tension, and aggregation behavior by altering the length and density of the PEG chains. This tunability enhances the versatility of DMPE-PEG liposomes for various applications. |
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| DC66233 |
DOPE-PEG-Lactoferrin
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66234 |
DOPE-PEG-AC
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66235 |
DOPE-PEG-TCO
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66236 |
DOPE-PEG5000-Streptavidin
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66237 |
DOPE-PEG-cRGD
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66238 |
DOPE-PEG-RGD
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66239 |
DOPE-PEG-Transferrin
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.
The transferrin receptor (TfR) is a transmembrane glycoprotein whose function is to mediate iron absorption through its interaction with transferrin. In normal cells, the expression level of the receptor is low, and the expression of the transferrin receptor in zhongliu cells (such as lung adenocarcinoma, chronic lymphocytic baixuebing and non-Hodgkin tumor) is significantly increased due to the increased demand for iron in rapidly growing cells [2-4].
At present, two transferrin receptors, TfR1 and TfR2, have been found, both of which are type II transmembrane glycoproteins that bind to transferrin and mediate iron absorption. TfR1 is expressed in many cells (such as red blood cells, hepatocytes, monocytes), and can change its conformation according to the change of environmental pH, and convert the results of conformational change into a change in the binding strength of transferrin.
TfR2 is mainly expressed in the liver, and its main function may be to regulate and maintain the homeostasis of iron ions in the body, while its role in transporting iron ions to rapidly dividing tissues is weak. Using the effective targeting function of transferrin receptor, the cross-linking of transferrin and drugs can improve the specific binding ability of drugs, but also improve the effect. |
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| DC66240 |
DOPE-PEG-Cholesterol,CHOL,CLS
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.
Cholesterol is the basic substance of cell membrane and liposome, is also an indispensable important substance of animal tissue cells, it not only participates in the formation of cell membrane, but also is the raw material of synthesis of bile acid, vitamin D and steroid hormone.
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| DC66241 |
DOPE-PEG-DBCO
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.
DBCO (diphenylcycloctene) is a cycloalkyne, CAS: 1255942-06-3, chemical formula: C18H16N2O, that can react with azide (-N3) compounds in aqueous solutions through a strain-facilitated 1, 3-dipole cycloaddition reaction, a biological orthogonal reaction also known as a cupr-free click reaction. The reaction has excellent selectivity and biocompatibility, so the complementary reagents can form covalent bonds with functionally rich biological systems. Copper-free click reaction has been a powerful tool for catalyst-free bioconjugation. DBCO reagent has affinity and stability in water-based buffers and can be used to label azide-modified biomolecules with high specificity and reactivity. Active esters modify molecules with primary amines. |
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| DC66242 |
DOPE-PEG-TPP
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66243 |
DOPE-PEG-HSA
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66244 |
DOPE-PEG-CHO
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.
A covalent bond in the carbonyl group is connected to the hydrogen atom and formed by a univalent atomic group, called aldehyde group, aldehyde group structure simple formula is -CHO, aldehyde group is a hydrophilic group, so the organic matter with aldehyde group (such as acetaldehyde, etc.) has a certain water solubility. Aldehydes, sugars, aldehydes, glucose, maltose and other molecules contain aldehyde groups. The aldehydes are active and prone to condensation and nucleophilic addition reactions. The aldehyde group can be reduced to hydroxymethyl (-CH2OH) or oxidized to carboxylic (-COOH). |
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| DC66245 |
DOPE-PEG-Dopamine
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66246 |
DOPE-PEG-Heparin
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.
Heparin, named after its discovery in the liver, is a mucopolysaccharide sulfate composed of glucosamine, L-idosaccharide, n-acetylglucosamine and D-glucuronic acid, with an average molecular weight of 15KDa and a strong acid. It is also found in tissues such as lungs and intestinal mucosa, and is a natural anticoagulant in animals.
Naturally occurring in mast cells, it is now mainly extracted from the mucous membrane of the bovine lung or the small intestine of pigs.
As an anticoagulant, it is a polymer formed by alternating connection of two polysaccharides, which has kang coagulation effect in vivo and in vitro, mainly used in xueshaun embolic diseases, cardiac xuguan surgery,xinzang catheterization, extracorporeal circulation, hemodialysis and so on.
With the development of pharmacology and clinical medicine, the application of heparin continues to expand. |
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| DC66247 |
DOPE-PEG-BSA
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66248 |
DOPE-PEG-NHS
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66249 |
DOPE-PEG-OH
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66250 |
DOPE-PEG-SH
Featured
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DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy.
Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. |
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| DC66251 |
DOPE-PEG-FA
Featured
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Folic Acid (Folic Acid), also known as pteroyl glutamate, is a water-soluble vitamin, is a light orange yellow crystal or sheet, the molecular formula is C19H19N7O6, the molecular weight is 441.4 because of the rich content in green leaves.
There are several forms in nature, and its parent compound is a combination of pteridine, p-aminobenzoic acid and glutamic acid.
PEG derivatives are also known as PEG (polyethylene glycol) modifiers, modifying PEG, etc. PEG is a functional group that is currently mainly used for protein drug modification to increase the half-life in vivo and reduce immunogenicity, while also increasing the water solubility of the drug. PEG derivatives have been widely used in pharmaceutical research and development in recent years, and play an important role in the sustained release of drugs.
DOPE Conjugate pegylates are phospholipids and pegylates combined with hydrophilic and hydrophobic properties. Polyethylene glycol phospholipid liposome forming material can be used for drug delivery, gene transfection and vaccine delivery. |
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| DC66252 |
DOPE-PEG-Biotin
Featured
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DOPE-PEG-Biotin is a bilateral active PEG derivative, also known as PEG (polyethylene glycol) modifier, modified PEG, etc. PEG is a functional group that is currently mainly used for protein drug modification to increase the half-life in vivo and reduce immunogenicity, while also increasing the water solubility of the drug. PEG derivatives have been widely used in pharmaceutical research and development in recent years, and play an important role in the sustained release of drugs. Biotin has a high binding force on avidin or streptavidin, and the biotin/avidin system is widely used in the detection and separation of biomolecules. |
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