| DC65564 |
GalNAc-L96-PS
Featured
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| DC65565 |
GalNac-L96
Featured
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GalNac-L96, the G-rich oligonucleotides carrying the longer GalNAc linker that can be used for delivery of nucleic acid drugs[1]. |
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| DC60492 |
244cis |
244-cis is an ionizable, liver-specific lipid. 244-cis LNP that induces lower immune responses than the responses evoked by previously used LNPs. 244-cis LNP and low-dose adeno-associated virus could minimize side effects and achieve a therapeutic threshold in hemophilia A mice. |
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| DC60494 |
76-O17Se |
76-O17Se is a lipidoid for the efficient delivery of antiCD19 mRNA CAR to murine primary macrophages. 76-O17Se is more efficient than delivery with lipofectamine 2000 (LPF2K) or MC3 |
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| DC60495 |
9322-O16B
Featured
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9322-O16B is a lipidoid for the efficient delivery of antiCD19 mRNA CAR to murine primary macrophages. LNP 9322-O16B is more efficient than delivery with lipofectamine 2000 (LPF2K) or MC3. |
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| DC65618 |
DSPE-NHS
Featured
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DSPE-NHS is a bioconjugation phospholipid molecule with two hydrophobic lipid tails. DSPE-NHS is a self-assembling reagent which forms lipid bilayer in aqueous solution. DSPE-NHS can be used to prepare liposomes as drug nanocarrier. |
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| DC65619 |
LNP Lipid-8 |
LNP Lipid-8 (11-A-M) is an ionizable lipid, which can be used for lipid nanoparticles (LNP) to deliver siRNA to T cells without targeting to ligands. LNP LIPs-8 loaded with GFP siRNA (siGFP), and significantly causes GFP gene silencing in mice model. |
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| DC65620 |
cKK-E15 |
cKK-E15 is an ionizable cationic lipid and a derivative of cKK-E12 that has been used in the generation of lipid nanoparticles (LNPs).1 LNPs containing cKK-E15 and encapsulating Cre mRNA induce the expression of Cre in Kupffer cells, endothelial cells, and hepatocytes in Ai14 mice engineered to express the fluorescent protein tdTomato upon translation of Cre. |
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| DC65622 |
306Oi9-cis2 |
306Oi9-cis2 is an ionizable cationic lipid.
WARNING This product is not for human or veterinary use. |
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| DC65623 |
Lipid AX4 |
Lipid AX4 is an ionizable cationic lipid (pKa = 6.89) that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. |
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| DC65624 |
RM 137-15 |
RM 137-15 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing RM 137-15 and encapsulating mRNA encoding a fluorescent reporter increase fluorescence in the livers of mice. |
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| DC65625 |
C12-SPM |
C12-SPM is a polyamine branched-chain lipidoid.1 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of siRNA targeting the host protein kinase protein kinase C-related kinase 2 (PRK2) to inhibit hepatitis C virus (HCV) replication in Huh7 cells and a mouse model of HCV infection. |
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| DC65626 |
C14-SPM |
C14-SPM is a polyamine branched-chain lipidoid.1 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of siRNA. |
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| DC60499 |
C14-A1 |
Lipid C14-A1 is an ionizable lipid. C14-A1-LPN is a potent and safe LNP platform to deliver Foxp3 mRNA to CD4+ T cells to engineer immunosuppressive FP3T cells. |
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| DC60502 |
GalNAc-Lipid GL6
Featured
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GalNAc-Lipid GL6 is a multi-valent N-acetylgalactosamine (GalNAc) targeting ligand. GalNAc-LNP is capable of delivering a CRISPR base editing therapeutic via LDLR-independent pathways. |
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| DC60503 |
Lipid C12-A1
Featured
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Lipid C12-A1 is an ionizable lipid. C12-A1-LPN is a potent and safe LNP platform to deliver Foxp3 mRNA to CD4+ T cells to engineer immunosuppressive FP3T cells. C12-A1 has a slightly lower average cell viability than C14-A1. |
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| DC65680 |
Lipid 2-10
Featured
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Lipid 2-10 is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure. |
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| DC65682 |
RCB-4-8
Featured
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RCB-4-8 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.1 RCB-4-8-containing LNPs improve lung transfection efficiency by approximately 100-fold over MC3-containing LNPs in mice. |
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| DC60505 |
IR-19-Py(A20-0l) |
IR-19-Py(A20-0l) is an ionizable, degradable lipid for nebulized mRNA delivery. |
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| DC60506 |
IR-117-17 |
IR-117-17(A10-LIN) is an ionizable, degradable lipid for nebulized mRNA delivery. Nebulized IR-117-17 LNPs produced a 300-fold improvement in lung mRNA delivery over the top previously described LNP. and a two-fold improvement over the previously reported PBAE, including up to a 45-fold improvement in delivery to the large airways. |
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| DC60508 |
4A3-SCC-10
Featured
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4A3-SCC-10 is a biodegradable ionizable lipid with superior endosomal escape and rapid mRNA release ability. In comparison with DLin-MC3-DMA, 4A3-SCC-10-formulated LNPs significantly improve mRNA delivery in livers by 87-fold. |
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| DC60509 |
4A3-SCC-PH
Featured
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4A3-SCC-PH is a biodegradable ionizable lipid with superior endosomal escape and rapid mRNA release ability. In comparison with DLin-MC3-DMA, 4A3-SCC-PH-formulated LNPs significantly improve mRNA delivery in livers by 176-fold. 4A3-SCC-PH enhance Fluc mRNA release and luciferase expression in tumor cells, further assisting cancer metastasis delineation and surgical resection. |
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| DC65701 |
L-369
Featured
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L-369 (Lipid 369,L369) is novel class of ionizable lipid for siRNA delivery with improved in vivo elimination profile with excellent translation across species,including NHP, wide safety margin. |
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| DC60510 |
Iso-A11B5C1
Featured
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Iso-A11B5C1 is an ionizable lipid. The iso-A11B5C1 LNP demonstrates a high level of muscle-specific mRNA delivery efficiency. exhibiting transfection efficiency comparable to the commercially available lipid SM-102, while considerably reducing inadvertent mRNA expression in main organs such as the liver and spleen.Additionally, study results show that intramuscular administration of mRNA formulated with iso-A11B5C1 LNP caused potent cellular immune responses, even with limited expression observed in lymph nodes. |
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| DC65713 |
mPEG-5000-DSPE, Na
Featured
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DSPE-MPEG(5000) is a PEGylated form of 1,2-distearoyl-rac-glycero-3-PE (DSPE). It has been used in the synthesis of lipid nanoparticles (LNPs) and liposomes for in vitro and in vivo two-photon bioimaging. |
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| DC65717 |
DPPE
Featured
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DPPE is a derivative of phosphatidylethanolamine with (16:0) palmitoyl acyl chains |
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| DC65727 |
DMPG
Featured
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DMPG is a phospholipid containing the saturated long-chain (14:0) myristic acid. |
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| DC65728 |
DSPA
Featured
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DSPA is a form of phosphatidic acid (PA) containing a phosphatidic acid head group and 18:0 fatty acids |
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| DC65729 |
DOPG-Na
Featured
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DOPG-Na is a phospholipid containing the long-chain (18:1) fatty acid oleic acid inserted at the sn-1 and sn-2 positions. It can be used in the generation of micelles, liposomes, and other artificial membranes. DOPG is an anionic phospholipid derivative. The negatively charged liposomes prepared with DOPG has been found to possess the best loading capacity and encapsulation rate for Peptide Nucleic Acid (PNA) oligomers. |
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| DC65731 |
DPPA
Featured
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DPPA is a form of phosphatidic acid (PA). |
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