| DC66134 |
DSPE-SS-PEG-CY5
Featured
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| DC66135 |
DSPE-SS-PEG-Silane
Featured
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| DC66136 |
DSPE-SS-PEG-CHO
Featured
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| DC66137 |
DSPE-SS-PEG-OPSS
Featured
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| DC66138 |
DSPE-SS-PEG-RB
Featured
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| DC66139 |
DSPE-SS-PEG-Biotin
Featured
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| DC66140 |
DSPE-SS-PEG-FA
Featured
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| DC66141 |
DSPE-SS-PEG-COOH
Featured
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| DC66142 |
DSPE-SS-PEG-FITC
Featured
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| DC66143 |
DSPE-SS-PEG-SH
Featured
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| DC66144 |
DSPE-SS-PEG-NH2
Featured
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| DC66147 |
DSPE-TK-PEG-COOH
Featured
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The polymer with ketone mercaptan as the fragment can form the shell of the nanocore, and simultaneously contain the polyorubicin and light sensitive compounds to achieve dual roles. Ketothiol polymers can also be used directly as drug carriers to contain paclitaxel ROS responsive groups, often in combination with a variety of methods. ROS, as the connecting part, connects the hydrophilic part and the hydrophobic part of the nanocarrier. When the nanocarrier encounters ROS, it breaks and releases drugs: the ROS responsive group can also act as the part connecting drug molecules and nanocarriers to release drugs under oxidation. Common ROS responsive groups generally contain sulfur, boron and tellurium. In addition, in order to inactivate the protein, ROS responsive groups can also be used to block the active center of the protein. Common ROS responsive genes include: polypropylene sulfide, borate, thione, tellurium, selenium, ferrocene, anthocyanins, etc. |
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| DC66148 |
DSPE-TK-PEG-SH
Featured
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The polymer with ketone mercaptan as the fragment can form the shell of the nanocore, and simultaneously contain the polyorubicin and light sensitive compounds to achieve dual roles. Ketothiol polymers can also be used directly as drug carriers to contain paclitaxel ROS responsive groups, often in combination with a variety of methods. ROS, as the connecting part, connects the hydrophilic part and the hydrophobic part of the nanocarrier. When the nanocarrier encounters ROS, it breaks and releases drugs: the ROS responsive group can also act as the part connecting drug molecules and nanocarriers to release drugs under oxidation. Common ROS responsive groups generally contain sulfur, boron and tellurium. In addition, in order to inactivate the protein, ROS responsive groups can also be used to block the active center of the protein. Common ROS responsive genes include: polypropylene sulfide, borate, thione, tellurium, selenium, ferrocene, anthocyanins, etc. |
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| DC66149 |
DSPE-m-PEG-NHS (MW 3400)
Featured
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DSPE-m-PEG-NHS (MW 3400) is a pegylated phospholipid derivatives which can be used to prepare liposome or lipid nanoparticles for targeted drug delivery system, such as DNA or mRNA vaccine. |
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| DC66151 |
DSPE-TK-PEG-NH2
Featured
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| DC66152 |
DSPE-TK-PEG-FA
Featured
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| DC66153 |
DSPE-TK-PEG-CHO
Featured
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| DC66154 |
DSPE-TK-PEG-NPC
Featured
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| DC66155 |
DSPE-TK-PEG-FITC
Featured
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| DC66156 |
DSPE-TK-PEG-cRGD
Featured
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| DC66157 |
DSPE-TK-mPEG
Featured
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| DC66159 |
DSPE-PEG-BSA
Featured
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Bovine serum albumin (BSA), a globulin in bovine serum, contains 607 amino acid residues with a molecular weight of 66.446KDa and an isoelectric point of 4.7. Bovine serum albumin has been widely used in biochemical experiments. The total length of BSA precursor protein is 607 amino acids. The precursor protein removes 18 signaling peptides and 6 propeptides from the N terminal to form a mature BSA protein with 583 amino acids and a molecular weight of about 66.5kDa. The surface of BSA contains a large number of carboxyl and amino groups, which can be used to bind the activated groups on the surface, and can be used as a carrier of small molecules. BSA is coupled with antibodies to form carrier-haptens conjugate. |
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| DC66160 |
DSPE-PEG-Heparin
Featured
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Heparin, named after its discovery in the liver, is a mucopolysaccharide sulfate composed of glucosamine, L-idosaccharide, n-acetylglucosamine and D-glucuronic acid, with an average molecular weight of 15KDa and a strong acid. It is also found in tissues such as lungs and intestinal mucosa, and is a natural anticoagulant in animals. Naturally occurring in mast cells, it is now mainly extracted from the mucous membrane of the bovine lung or the small intestine of pigs. As an anticoagulant, it is a polymer formed by alternating connection of two polysaccharides, which has kang ningxue effect both in vivo and in vitro. Mainly used for extracorporeal circulation, hemodialysis and so on. With the development of pharmacology and clinical medicine, the application of heparin continues to expand.
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| DC66161 |
DSPE-PEG-HSA
Featured
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Serum protein is the most abundant protein in plasma. Each protein molecule can carry seven fatty acid molecules. These fatty acid molecules bind to gaps in the protein, where their carbon-rich tails are buried safely away from surrounding water molecules. Serum proteins can also carry many other molecules that are insoluble in water. Serum proteins, in particular, can carry many drug molecules, such as ibuprofen. Human serum albumin (HSA) is a highly water-soluble globular monomer plasma protein with a relative molecular weight of 67KDa, composed of 585 amino acid residues, one sulfhydryl group and 17 disulfide bonds. In nanoparticle carriers, HSA nanoparticles are characterized by their ability to bind to various drug molecules, stability during storage and in vivo use, non-toxicity and antigenicity, biodegradability, repeatability, amplification of the production process and better control of release characteristics |
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| DC66162 |
DSPE-PEG-Transferrin
Featured
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The transferrin receptor (TfR) is a transmembrane glycoprotein whose function is to mediate iron absorption through its interaction with transferrin. In normal cells, the expression level of the receptor is low, and the expression of the transferrin receptor in cells (chronic lymphocytic non-Hodgkin tumors) is significantly increased due to the increased demand for iron in rapidly growing cells [2-4]. At present, two transferrin receptors, TfR1 and TfR2, have been found, both of which are type II transmembrane glycoproteins that bind to transferrin and mediate iron absorption. TfR1 is expressed in many cells (such as red blood cells, hepatocytes, monocytes), and can change its conformation according to the change of environmental pH, and convert the results of conformational change into a change in the binding strength of transferrin. TfR2 is mainly expressed in the liver, and its main function may be to regulate and maintain the homeostasis of iron ions in the body, while its role in transporting iron ions to rapidly dividing tissues is weak. Using the effective targeting function of transferrin receptor, the cross-linking of transferrin and drugs can improve the specific binding ability of drugs, but also improve the effect. |
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| DC66163 |
DSPE-PEG-RGD
Featured
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RGD's receptors are integrins αvβ3 and αvβ5, which can mimic cell adhesion proteins and bind specifically to 11 kinds of integrins, which can effectively adhere to biological materials. DSPE-PEG-RGD can be used to make micelles and vesicles. The liposomes formed by RGD-PEG-DSPE can act directly on the target to form an active targeting effect. Rgd-peg-dspe peptide RGD polyethylene glycol phospholipid can be used for passive targeting of micelles and vesicles, active targeting research and drug delivery. DSPE (1, 2-distearoyl-SN-glycerol-3-phosphate ethanolamine) is a saturated 18-carbon phospholipid commonly used in the synthesis of liposomes. Polyethylene glycol (PEG) -coupled DSPE is hydrophilic and can be used for drug delivery, gene transfection, and biomolecular modification. Polyethylene glycol can enhance solubility and stability, reduce the nonspecific binding of charged molecules, and reduce the immunogenicity of polypeptides. |
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| DC66164 |
DSPE-PEG-Streptavidin
Featured
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The streptavidin molecule consists of four identical peptide chains, and the contents of glycine and alanine are relatively large in the amino acid composition, and the active group binding biotin is also the tryptophan residue in the peptide chain. Streptavidin is a slightly acidic (pH6.0) protein and does not carry any sugar groups. Under the action of proteolytic enzyme, streptavidin can be broken between N-terminal 10 ~ 12 and C-terminal 19 ~ 21, and the formed core streptavidin still maintains the complete ability to bind biotin. The activity unit of streptavidin is also expressed in terms of the amount required to bind 1μg biotin, and the high activity of 1mg streptavidin can reach 18U.
streptavidin (SA) is a protein secreted by streptomyces avidinii with a molecular weight of 65kD. Streptavidin molecules are composed of four identical peptide chains, each of which can bind a biotin without any sugar group, so like avidin, one streptavidin molecule can also bind four biotin molecules, and the affinity constant (K) of both is 1015mol/L. Streptavidin is more widely applicable than avidin. |
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| DC66165 |
DSPE-PEG-Lactoferrin
Featured
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The affinity between lactoferrin and iron ion is very high, which is 250 to 300 times that of transferrin. According to the difference of lactoferrin binding iron ions, it can be divided into three types: iron deficiency type, iron semi-satiation type and iron saturated type. Different types of lactoferrin have different ability to resist pasteurization thermal denaturation, in which iron saturated type resistance is strong, iron deficiency type resistance is weak. Lactoferrin can bind not only Fe3+ and Fe2+, but also Cu2+, Mn2+ and Zn2+. |
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| DC66166 |
DSPE-PEG-Glucose;DSPE-PEG2000-Glucose
Featured
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Glucose, organic compound, molecular formula C6H12O6. It is one of the most widely distributed and important monosaccharides in nature, and it is a polyhydroxyaldehyde. Glucose plays an important role in the field of biology, that is, the main energy supplier of living things. Plants produce glucose through photosynthesis. Liposome has the advantages of low toxicity, easy preparation, as a carrier of both water-soluble and fat-soluble drugs, suitable for a variety of drug delivery routes, improve drug stability, and achieve targeted drug delivery. However, after the liposome enters the body, it is easy to be taken up and cleared by RES cells due to the specific conditioning effect of opsonins in plasma on the liposome and the non-specific hydrophobic interaction between RES cells and liposome. |
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| DC66168 |
DSPE-PEG-ICG
Featured
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DSPE phospholipids can be used as pharmaceutical excipients for emulsification and drug solubilization, and are important materials for slow release drug preparations such as liposomes, fat milk and nanoparticles in recent years.
Modification of phospholipid molecules can make these preparations have the ability of release and targeting under specific conditions.
Common modification methods include: disintegration time; Introducing immune factors to enhance targeting; Introduce markers for diagnosis and tracking. |
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