DSPE-PEG-Transferrin

  Cat. No.:  DC66162   Featured
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
The transferrin receptor (TfR) is a transmembrane glycoprotein whose function is to mediate iron absorption through its interaction with transferrin. In normal cells, the expression level of the receptor is low, and the expression of the transferrin receptor in cells (chronic lymphocytic non-Hodgkin tumors) is significantly increased due to the increased demand for iron in rapidly growing cells [2-4]. At present, two transferrin receptors, TfR1 and TfR2, have been found, both of which are type II transmembrane glycoproteins that bind to transferrin and mediate iron absorption. TfR1 is expressed in many cells (such as red blood cells, hepatocytes, monocytes), and can change its conformation according to the change of environmental pH, and convert the results of conformational change into a change in the binding strength of transferrin. TfR2 is mainly expressed in the liver, and its main function may be to regulate and maintain the homeostasis of iron ions in the body, while its role in transporting iron ions to rapidly dividing tissues is weak. Using the effective targeting function of transferrin receptor, the cross-linking of transferrin and drugs can improve the specific binding ability of drugs, but also improve the effect.
Cas No.:
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
Cat. No. Product name Field of application
DC67097 DSPE-PEG(2000)-amine (sodium salt) DSPE-PEG(2000)-amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE (DSPE; Item No. 15095). It has been used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents. DSPE-PEG(2000)-amine has also been used in the synthesis of fluorescein isothiocyanate-loaded mesoporous silica nanoparticles for imaging applications.4 It can be conjugated to a variety of functional molecules for improved cellular targeting and uptake of DSPE-PEG(2000)-amine-containing nanoparticles.
DC66440 mPEG-DSPE
DC66299 DSPE-PEG-Cy5.5 DSPE-PEG-Cy5.5is a phospholipid. Phospholipids have good biocompatibility and significant amphiphilic characteristics, making them the main and suitable dosage form or excipient in drug formulations, thereby achieving better therapeutic effects. "&B26&"can be used in drug delivery research."
DC66298 DSPE-PEG-Cy5(MW 2000 ) The molecules can be labeled in the aqueous phase without organic solvents. Therefore, the product is especially suitable for labeling proteins that are easily denatured in the organic phase and proteins with low solubility. Polyethylene glycol phospholipid liposomes form high-quality materials, which can be used for drug delivery, gene transfection and vaccine delivery. Pegylated phospholipids can significantly improve blood circulation time and stabilize drug encapsulation. These materials can also be used for targeted drug delivery by modifying surface ligands such as antibodies and peptides. (DSPE) conjugated polyethylene glycol is a combination of phospholipids and polyethylene glycol, which has hydrophilicity and hydrophobicity. These materials can also be used for targeted drug delivery by modifying ligands with target surfaces, such as antibodies and peptides. Cyanogen dye cyanine is often used in biomolecular labeling, fluorescence imaging and other fluorescent biological analysis. Cy5 (sulfo-cyanine5) is a reactive dye used to label amino groups of peptides, proteins and oligonucleotides. Excitation wavelength (nm): 649, emission wavelength (nm): 670.
DC66296 DSPE-PEG-alkyne (MW 2000) The phospholipid polyethylene glycol alkyne (DSPE PEG Alkyne) can be used to modify proteins, peptides and other materials or small molecules. Alkynyl (- ALK) can react with copper catalyzed azide in aqueous solution. 2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) conjugated polyethylene glycol is a combination of phospholipid and polyethylene glycol with hydrophilicity and hydrophobicity. Polyethylene glycol phospholipid liposomes form high-quality materials, which can be used for drug delivery, gene transfection and vaccine delivery. PEGylated phospholipid can significantly improve blood circulation time and stabilize drug encapsulation. These materials can also be used for targeted drug delivery by modifying ligands with target surfaces such as antibodies and peptides.
DC66295 DSPE-PEG-CY7 Polyethylene glycol phospholipid is an excellent material to form liposomes, which can be used for gene transfection, vaccine delivery, drug transportation, and targeted drug delivery. Phospholipids are hydrophobic and hydrophilic. It can be used to modify protein drugs, peptide compounds, organic small molecule drugs, biological materials, etc. Cy7 labeled PEG derivatives are used for fluorescence tracing or fluorescence observation.
DC66294 DSPE-PEG-NBD DSPE-PEG-NBD is a fluorescent phospholipid PEG conjugate, which can be used as a lipid membrane probe. The excitation/emission wavelength of NBD is 460 nm/534 nm.
DC66293 DSPE-PEG-N3 DSPE-PEG-N3 is a click chemical PEG reagent. Azide group is easy to react with alkynyl group under the catalysis of copper catalyst. It can also react directly with DBCO without any catalyst. DSPE (1,2-distearoyl-sn-glycerol-3-phosphoethanolamine) is a saturated 18 carbon phospholipid, which is commonly used in the synthesis of liposomes. Polyethylene glycol (PEG) - coupled DSPE is hydrophilic and can be used for drug delivery, gene transfection and biomolecular modification. The PEG of phospholipid significantly improved the blood circulation time and stability of the capsule drug. Polyethylene glycol can enhance the solubility and stability, reduce the non-specific binding of charged molecules on the surface, and reduce the immunogenicity of polypeptides. Azide (- N3) can react with copper catalyzed alkynes in aqueous solution and be reduced to amino groups. Polyethylene glycol can increase solubility and stability. It can also inhibit the nonspecific binding of charged molecules on the modified surface.
DC66292 DSPE-PEG-NPC DSPE-PEG-NPC is a linear heterobifunctional polyglycolation reagent containing DSPE phospholipids and NPC groups. It is a useful self-assembly reagent for preparing PEGylated liposomes or micelles, and also provides a combination of NPC group and thiol containing molecules.
DC66291 DSPE-PEG-OPSS DSPE-PEG-OPSS, DSPE (1,2-distearoyl-sn-glycerol-3-phosphoethanolamine) is a saturated 18 carbon phospholipid, commonly used in the synthesis of liposomes. Polyethylene glycol (PEG) - coupled DSPE is hydrophilic and can be used for drug delivery, gene transfection and biomolecular modification. The PEG of phospholipid significantly improved the blood circulation time and stability of the capsule drug. Polyethylene glycol can enhance the solubility and stability, reduce the non-specific binding of charged molecules on the surface, and reduce the immunogenicity of polypeptides. Mercaptopyridine reacts with mercapto group to release pyridine ring and generate stable disulfide bond.
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