| DC66551 |
GalNAc-Cluster-HHA-CE Phosphoramidite
Featured
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| DC66555 |
GalNAc-L96 Linker-Acid
Featured
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| DC66557 |
GalNAc-L96 Linker-Azide
Featured
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| DC66559 |
Peracetylated GalNAc PEG linker-Azide
Featured
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| DC66560 |
GalNAc-L96-tert-butyl ester
Featured
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GalNAc-L96-tert-butyl ester is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC66561 |
Peracetylated GalNAc succinimidyl pentanoate
Featured
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| DC66564 |
Peracetylated GalNAc PEG linker-Acid-1
Featured
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| DC66565 |
Peracetylated GalNAc-L96-Acid-1
Featured
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| DC66568 |
Peracetylated GalNAc PEG linker-Amino-1
Featured
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| DC66569 |
GalNAc-L96-Amide
Featured
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| DC66572 |
Peracetylated GalNAc PEG linker-Amino-2
Featured
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| DC66574 |
Peracetylated GalNAc-L96-1
Featured
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| DC66575 |
Peracetylated GalNAc PEG linker-Acid-2
Featured
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| DC60619 |
12T-O14 |
12T-O14 is a amidine-incorporated degradable (AID) lipid for versatile mRNA delivery. 12T-O14-LNPs mediate efficient intramuscular delivery of mRNA vaccines and systemic delivery of mRNA therapeutics without noticeable toxicity. 12T-O14 serves as a superior supplementary lipid to redirect liver-tropic LNPs to selectively target the lung or spleen via simple adjustment of the formulation. |
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| DC60636 |
Acid-degradable Cationic Lipid (ADC)
Featured
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Acid-degradable Cationic Lipid (ADC) composed of cationic lipid is synthesized with the azido-acetal linker and used to generate RD-LNPs, which significantly improves the performance of LNP-mRNA complexes in vitro and in vivo. |
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| DC60638 |
Acid-degradable PEG Lipid (ADP-2k)
Featured
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Acid-degradable PEG Lipid (ADP) composed of polyethylene glycol lipid is synthesized with the azido-acetal linker and used to generate RD-LNPs, which significantly improves the performance of LNP-mRNA complexes in vitro and in vivo. |
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| DC60639 |
Acid-degradable Anionic Lipid (ADA)
Featured
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Acid-degradable Anionic Lipid (ADA) composed of anionic lipid is synthesized with the azido-acetal linker and used to generate RD-LNPs, which significantly improves the performance of LNP-mRNA complexes in vitro and in vivo. |
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| DC66648 |
CP-LC-1143
Featured
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Lipid CP-LC-1143 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo, with no signs of toxicity. |
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| DC66649 |
CP-LC-1254 |
Lipid CP-LC-1254 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo, with no signs of toxicity. |
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| DC66650 |
CP-LC-0729 |
CP-LC-0729 is an ionizable lipid that significantly surpasses the MC3 in protein expression while showing no in vivo toxicity. CP-LC-0729 demonstrates a very high selectivity to lungs with a remarkable 32-fold increase in protein expression compared to MC3. |
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| DC66652 |
CP-LC-0867 |
Lipid CP-LC-0867 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo, with no signs of toxicity. |
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| DC66653 |
C9-200 |
C9-200 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs).1 LNPs containing C9-200 and encapsulating mRNA encoding erythropoietin (EPO) increase serum EPO levels in mice. LNPs containing C9-200 and encapsulating mRNA encoding the Cas9 nuclease and small-guide RNA (sgRNA) targeting transthyretin (TTR) induce 3-fold higher hepatic insertion and deletion (indel) formation than LNPs containing C12-200 (Item No. 36699) and encapsulating mRNA encoding Cas9 in mice. |
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| DC66654 |
Lipid N2-3L |
Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) that has been used in the generation of supramolecular lipid nanoparticles (SMLNPs) encapsulating mRNA for use in vitro and in vivo.1 SMLNPs containing lipid N2-3L and encapsulating a luciferase reporter accumulate at the site of injection and in the draining lymph nodes of mice. Lipid N2-3L-containing SMLNPs encapsulating ovalbumin mRNA and the toll-like receptor 7/8 (TLR7/8) agonist R-848 (Item No. 14806) as an adjuvant promote dendritic cell maturation and antigen presentation, reduce tumor volume, and increase survival in an MC-38-OVA murine model of colon cancer. |
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| DC66655 |
YHS-12 |
YHS-12 is an ionizable cationic lipid (pKa = 6.506) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo.1 LNPs containing YHS-12 and the macrophage targeting peptide CRVLRSGSC and encapsulating mRNA encoding chimeric antigen receptor targeting methicillin-resistant S. aureus (MRSA) and siRNA targeting caspase-11 increase the phagocytosis rate of MRSA in RAW 264.7 macrophages and primary mouse bone marrow-derived macrophages (BMDMs). Intravenous administration of these LNPs decreases blood bacterial burden and increases survival in a model of sepsis using cyclophosphamide-induced immunosuppressed mice. |
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| DC66715 |
HSPC
Featured
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HSPC is a natural product. Hydrogenated soya phosphatidylcholines can extend drug release in regard to drug loading and solubility for oral drug delivery of watersoluble drugs. |
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| DC60662 |
Si6-C14b |
Si6-C14b is a siloxane-incorporated lipid for livertargeting mRNA delivery. The siloxane moieties enhance cellular internalization of mRNA-LNPs and improve their endosomal escape capacity, augmenting their mRNA delivery efficacy. |
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| DC60663 |
Si5-N14
Featured
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Si5-N14 is a siloxane-incorporated lipid for lung-targeting mRNA delivery. The siloxane moieties enhance cellular internalization of mRNA-LNPs and improve their endosomal escape capacity, augmenting their mRNA delivery efficacy. |
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| DC60664 |
Si12-C10 |
Si12-C10 is a siloxane-incorporated lipid for spleen-targeting mRNA delivery. The siloxane moieties enhance cellular internalization of mRNA-LNPs and improve their endosomal escape capacity, augmenting their mRNA delivery efficacy. |
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| DC67023 |
Amvuttra
Featured
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| DC67024 |
Inotersen
Featured
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Inotersen is an antisense oligonucleotide that inhibits hepatic production of transthyretin (TTR).
The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Inotersen sodium) that retains the same biological activity. |
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