| DC81110 |
Lipid 202 (L202)
Featured
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L202 is a novel ionizable lipid for RNA delivery. |
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| DC72269 |
Tri-GalNAc(OAc)3 TFA
Featured
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Tri-GalNAc(OAc)3 TFA is a tri-GalNAc ligand that can be used for the synthesis of GalNAc-LYTAC. GalNAc-LYTAC engages the asialoglycoprotein receptor for targeted protein degradation. tri-GalNAc: triantenerrary N-acetylgalactosamine; LYTAC: lysosome-targeting chimera. |
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| DC82001 |
4A3-SC8
Featured
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4A3-SC8 is a novel Ionizable amino lipid for RNA delivery.The CRISPR-Cas9 gene editing system has been a hotspot in the
field of gene therapy, especially the gene correction induced by
homology-directed repair (HDR). However, its application has
various obstacles, such as large molecular weight, poor stability,
off-target risk, and the complexity of codeliver multiple genes.
Farbiak et al. established a novel ionizable lipid library consisting
of four distinct amine cores (3A3, 3A5, 4A1, 4A3) and nine
peripheries with different alkyl chain lengths (SC5-SC14), and screened out a class of iLNPs with ability of encapsulating
Cas9 mRNA, sgRNA and donor DNA simultaneously.
The delivery efficiency (quantified by luciferase mRNA expression)
and iLNPs toxicity were evaluated with three different cell
lines (HEK293T, HeLa, and IGROV-1), indicating the formulation
containing 4A3-SC8 was the best. 4A3-SC8 iLNPs successfully
induced HDR in HEK293 cells by one-pot delivery of Cas9
mRNA, sgRNA, and the correct ssDNA template. Confocal
microscopy imaging showed that a portion of blue fluorescence
in cells was corrected to green fluorescence. Furthermore, the
nucleic acid ratios of Cas9: sgRNA: donor DNA loading in
iLNPs at a ratio of 2:1:3 could maximize the HDR efficiency with
the editing efficiency up to 23%, which breaks through the current
bottleneck of HDR efficiency of only 1–5%. This progress is
undoubtedly an important advance in the gene therapy field to
cure diseases caused by genetic mutations. |
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| DC81060 |
ATX-001 |
ATX-001 is a novel ionizable cationic lipid compound for RNA delivery. |
|
| DC82003 |
A12-Iso5-2DC18 |
A12-Iso5-2DC18 is a novel amine containing lipid can be used for mRNA delivery, activate the stimulator of interferon genes (STING) pathway, and exhibit anti-tumor immunity. |
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| DC85060 |
ATX-081 |
ATX-081 is a novel ionizable lipid for rna delivery. |
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| DC85061 |
ATX-083 |
ATX-083 is a novel ionizable lipid for rna delivery. |
|
| DC85063 |
ATX-084 |
ATX-084 is an ionizable cationic lipids for RNA or Gene delivery. |
|
| DC86065 |
ATX-087 |
ATX-087 is a novel ionizable lipid for rna delivery. |
|
| DC86070 |
304-O13 (Trimidin)
Featured
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304O13 is a novel Biodegradable lipidoid for RNA delivery. |
|
| DC81075 |
CSL3 |
CSL3 is a novel cationic switchable lipid, pH-triggered molecular
switch for siRNA delivery.In vivo factor VII silencing efficiency of the CSL3-based formulations
was compared to that of the CSL4-based formulation
(Fig. 5E). CSL3-based LNP were found to demonstrate a
dose–response knockdown, resulting in significant silencing
efficacy (∼50% silencing) at 1 mg kg−1.These results confirm the crucial role of the
pH-sensitive conformational change of CSL3 in the in vivo
transfection efficacy, in agreement with the in vitro results. The
in vivo silencing efficacy of the CSL3 LNP may be further
improved by lowering the molar percentage of DMG-PEG2000 in
the formulation11,33 or by using combinatorial approaches to
enhance the potency of the CSL3 lipid structure as well as the
blood stability of the LNP (currently under investigation). |
|
| DC72286 |
Fomivirsen
Featured
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Fomivirsen (ISIS-2922 free base) is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen binds to and degrades the mRNAs encoding CMV immediate-early 2 protein, thus inhibiting virus proliferation. |
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| DC72426 |
DSPE-SPDP
Featured
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DSPE-SPDP is a phospholipid molecule. DSPE-SPDP can orient itself to form lipid bilayer in water. DSPE-SPDP can be used for the research of various biochemical. |
|
| DC72429 |
DSPE-glutaric acid
Featured
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DSPE-glutaric acid is a lipid. DSPE-glutaric acid can be used for the research of various biochemical. |
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| DC72430 |
DSPE-Mal
Featured
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DSPE-MAL is a thiol reactive a phospholipid compound. DSPE-MAL has two saturated fatty acids and can self-assemble in water to form lipid bilayer. DSPE-MAL can be used to prepare liposomes as drug nanocarrier. |
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| DC72432 |
DSPE-N3
Featured
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DSPE-N3 is a lipid. DSPE-N3 can be used for the research of various biochemical. |
|
| DC72546 |
Tri-GalNAc-NHS ester
Featured
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Tri-GalNAc-NHS ester is a LYsosome TArgeting Chimera (LYTAC) and a ligand of asialoglycoprotein receptor (ASGPR). ASGPR is a lysosomal targeting receptor specifically expressed on liver cells, for the degradation of extracellular proteins including membrane proteins. Tri-GalNAc-NHS ester can be used as a protein degrader and it can be used for the research of LYTAC. |
|
| DC82025 |
306-O12B-3
Featured
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306-O12B-3 is an ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of antisense oligonucleotides (ASOs). LNPs containing 306-O12B-3 localize to the liver after intravenous administration in mice. LNPs containing 306-O12B-3 in combination with other lipids encapsulating ASOs targeting the gene encoding proprotein convertase subtilisin kexin type 9 (PCSK9) decrease hepatic PCSK9 expression in mice. Intravenous administration of LNPs containing 306-O12B-3 and the cationic lipidoid NT1-O14B encapsulating ASOs against tau decreases tau expression and levels in mouse brain. |
|
| DC82101 |
AA3-DLin
Featured
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AA3-DLin is an ionizable cationic amino lipid (pKa = 5.8) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.LNPs containing AA3-DLin and encapsulating mRNA for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein induce immunogenicity in mice. |
|
| DC82102 |
PPZ-A10
Featured
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PPZ-A10 is an ionizable cationic lipid.It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo. Intraperitoneal administration of LNPs containing PPZ-A10 and encapsulating an mRNA reporter preferentially accumulates in hepatic Kupffer cells and splenic macrophages in mice. |
|
| DC82105 |
93-O17O
Featured
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93-O17O is a chalcogen-containing ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs). LNPs containing 93-O17O localize to the spleen after intravenous injection into mice.LNPs containing 93-O17O have been used for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice and for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens. |
|
| DC82209 |
Lipid 10a-26
Featured
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LIPID-10a-26 is an analogue of ALC-0315 with the head adjusted to imidazole. It is a novel cationic ionizable Lipid for RNA delivery. |
|
| DC82115 |
BAMP-TK-12 |
BAMP-TK-12 is ROS‐degradable lipid used for gene/RNA delivery. |
|
| DC82119 |
113-O16B
Featured
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113-O16B is a disulfide bond-containing ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. |
|
| DC82125 |
lipid 14
Featured
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LIPID 14 is a novel ionizable lipid used for mRNA delivery.In 2021, Elia et al. used lipid 2 LNPs and lipid 14 LNPs to deliver mRNA encoding SARSCoV-2 human Fc-conjugated receptor binding domain (RBDhFc
mRNA). While both lipid 274 LNP RBD-hFc mRNA and
lipid 14 LNP RBD-hFc mRNA induced equal cellular and
humoral responses in mice at an mRNA dose of 5 μg, only lipid
14 LNP RBD-hFc mRNA exhibited strong immunogenicity
following intradermal administration. Both intradermal administration
and intramuscular administration of lipid 14 LNPs
could activate antigen presenting cells (APCs), thus inducing
cellular responses. |
|
| DC82301 |
IC-8
Featured
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IC8 is an ionizable cationic lipid. It has been used in combination with other lipids for the formation of lipid nanoparticles (LNPs). Immunization with severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein mRNA in IC8- and manganese-containing LNPs induces IgG responses to SARS-CoV-2 Delta and Omicron variants in mice.1 Administration of mRNA encoding B7-H3 X CD3 bispecific T cell engaging (BiTE) antibodies in IC8-containing LNPs reduces tumor growth in MV4-11 and A375 mouse xenograft models. |
|
| DC82303 |
SSPalmM
Featured
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SSPalmM is an ionizable cationic disulfide-cleavable (SS-cleavable) proton-activated lipid-like material (SSPalm). |
|
| DC82305 |
80-O16B
Featured
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80-O16B is a disulfide bond-containing ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 for genome editing in mice. LNPs containing 80-O16B conjugated to phenylboronic acid (PBA) and encapsulating an mRNA reporter increase luciferase reporter expression in HeLa cancer cells.2 LNPs containing 80-O16B conjugated to PBA and encapsulating p53 mRNA decrease the viability of DU145 prostate and SiHa and HeLa cervical cancer cells. |
|
| DC83320 |
A-066 |
A066 is a lipid for RNA and vaccine delivery.A-066 is an analog of DODMA that contains a pyrrole
head group. A-066 LNPs encapsulating TetR siRNA could induce significant antitumor efficacy in orthotopic hepatocellular carcinoma models. |
|
| DC83215 |
DMAP-BLP |
DMAP-BLP is a lipid for RNA and vaccine delivery.DMAP-BLP exhibits optimized bilayer destabilizing and pKa properties leading to highly potent gene silencing in hepatocytes following IV administration that is similar to “gold standard” lipids such as DLinMC3-DMA. |
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