| DC45543 |
AT-9010 |
AT-9010, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 can inhibit SARS-CoV-2 replication. |
|
| DC45544 |
AT-9010 tetrasodium |
AT-9010 tetrasodium, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 tetrasodium can inhibit SARS-CoV-2 replication. |
|
| DC45774 |
AT-9010 triethylamine |
AT-9010 triethylamine, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 triethylamine can inhibit SARS-CoV-2 replication. |
|
| DC45780 |
Cleistanthin B |
Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo. |
|
| DC46076 |
Hispidulin 4'-O-β-D-glucopyranoside |
Hispidulin 4'-O-β-D-glucopyranosid, a natural compound, may serve as a potential COVID-19 main protease inhibitor. |
|
| DC46358 |
CCF0058981
Featured
|
CCF0058981 (CCF981), 3-chlorophenyl analogue, is a noncovalent SARS-CoV-2 3CLpro (SC2) inhibitor with an IC50 of 68 nM. CCF0058981 inhibits SC1 (SARS-CoV-1 3CLpro) with an IC50 of 19 nM. CCF0058981 has antiviral efficacy and has the potential for COVID-19 research. |
|
| DC46623 |
Guanosine triphosphate |
Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19. |
|
| DC46819 |
RdRP-IN-2 |
RdRP-IN-2 is a RNA dependent RNA polymerase (RdRp) inhibitor. RdRP-IN-2 significantly inhibits SARS-CoV-2 RdRp with an IC50 of 41.2 µM.RdRP-IN-2 also inhibits Feline coronavirus (FIPV) replication. |
|
| DC46820 |
Lufotrelvir |
Lufotrelvir (PF-07304814), a phosphate prodrug of PF-00835231, acts as a potent 3CLpro protease (Mpro) inhibitor with SARS-CoV-2 antiviral activity. Lufotrelvir binds and inhibits SARS-CoV-2 3CLpro activity with a Ki of 174nM. Lufotrelvir is promising single antiviral agent and also can be used for the research of combination with other antivirals that target other critical stages of the coronavirus life cycle. |
|
| DC46821 |
HeE1-2Tyr |
HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 µM) activity in vitro. |
|
| DC57120 |
PF07321332(nirmatrelvir)
Featured
|
PF07321332(nirmatrelvir) is a potent and orally active SARS-CoV 3C-like protease (3CLPRO) inhibitor . PF-07321332 targets to the SARS-CoV-2 virus and can be used for COVID-19 reseacrch. |
|
| DC58000 |
4'-fluorouridine (4'-FlU, EIDD-2749)
Featured
|
4'-fluorouridine (4'-FlU, EIDD-2749) is a ribonucleoside analog that inhibits respiratory syncytial virus (RSV), related RNA viruses, and SARS-CoV-2 with high selectivity index (EC50/CC50 of ≥1877) in cells and human airway epithelia organoids. 4'-FlU induces a delayed stalling of RSV and SARS-CoV-2 RdRP (RNA-dependent RNA polymerase). |
|
| DC47338 |
SARS-CoV-2-IN-9 |
SARS-CoV-2-IN-9 is an inhibitor binding to subsites S1 and S2 in SARS-CoV-2 main protease. |
|
| DC47339 |
NK007 |
NK007 is a novel anti-SARS-CoV-2 agent with an EC50 value of 30 nM. |
|
| DC47340 |
SARS-CoV-2-IN-7 |
SARS-CoV-2-IN-7 inhibits viral replication with a nanomolar IC50 value (844 nM) in SARS-CoV-2-infected Vero E6 cells. |
|
| DC47341 |
Cichoriin |
Cichoriin is an active compounds against SARS-CoV-2, and may be a potential candidate in treating severe COVID-19. |
|
| DC47342 |
SARS-CoV-2-IN-6 |
SARS-CoV-2-IN-6 is a SARS-CoV-2 3CLpro inhibitor that shows the most potent enzyme inhibitory IC50 value of 73 nM. |
|
| DC47343 |
XR8-69 |
XR8-69 is a SARS-CoV-2 PLpro inhibitor that shows low micromolar antiviral potency in SARS-CoV-2-infected human cells. |
|
| DC47344 |
SARS-CoV-2-IN-8 |
SARS-CoV-2-IN-8 is a SARS-CoV-2 main protease inhibitor with an IC50 value of 0.75 μM. |
|
| DC58060 |
VV116 (non-deuterated)
Featured
|
non-deuterated form of VV116.VV116 is an oral drug candidate of nucleoside analog against SARS-CoV-2. |
|
| DC47874 |
Vanillinbananin |
Vanillinbananin is an effective inhibitor of the ATPase activity of the SARS Coronavirus helicase with an IC50 value of 0.68 μM. |
|
| DC47906 |
SARS-CoV-2-IN-10 |
SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for therapeutic intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals. |
|
| DC47970 |
Iodobananin |
Iodobananin is an effective inhibitor of the ATPase activity of the SARS Coronavirus helicase with an IC50 value of 0.54 μM. |
|
| DC47994 |
Eubananin |
Eubananin is an effective inhibitor of the ATPase activity of the SARS Coronavirus helicase with an IC50 value of 2.8 μM. |
|
| DC48045 |
Bananin |
Bananin is an effective inhibitor of the ATPase activity of the SARS Coronavirus helicase with an IC50 value of 2.3 μM. |
|
| DC48055 |
Ansabananin |
Ansabananin is a weak inhibitor of the ATPase activity of the SARS Coronavirus helicase with an IC50 value of 51 μM. |
|
| DC59016 |
Ensitrelvir (S-217622)
Featured
|
S-217622 is the first oral non-covalent, non-peptidic SARS-CoV-2 3CL protease inhibitor with IC50 of 0.096 μM. S-217622 displays antiviral activity in vitro towards a range of SARS-CoV-2 variants and coronavirus families, favorable drug metabolism and pha |
|
| DC48105 |
Antiviral agent 5 |
Antiviral agent 5 is an intermediate used in antiviral agents targeting 3C and 3CL proteases including SARS-CoV-2 Mpro. |
|
| DC48106 |
MERS-CoV-IN-1 |
MERS-CoV-IN-1 exhibits excellent inhibitory activity against coronavirus. MERS-CoV-IN-1 is useful as a pharmaceutical composition for preventing coronavirus-induced diseases (MERS-CoV and SARS) (extracted from patent WO2018174442A1, compound 1). |
|
| DC48107 |
Ensitrelvir fumarate
Featured
|
Ensitrelvir (S-217622) fumarate is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor (IC50=13 nM). |
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