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β-Secretase Inhibitor II

  Cat. No.:  DC46382  
Chemical Structure
263563-09-3
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More than 5000 active chemicals with high quality for research!
Field of application
β-Secretase Inhibitor II is a β-Secretase inhibitor. β-Secretase Inhibitor II is a simple tripeptide aldehyde (IC50=700 nM for inhibition of total Aβ and IC50=2.5 μM for Aβ1–42). β-Secretase Inhibitor II can be used for the research of Alzheimer's disease.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 263563-09-3
Chemical Name: β-Secretase Inhibitor II
SMILES: O=C(N[C@H](C=O)CC(C)C)[C@H](CC(C)C)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O
Formula: C25H39N3O5
M.Wt: 461.59
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_30245_DC46382_263563-09-3
COA
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Cat. No. Product name Field of application
DC47722 β-Secretase Inhibitor III β-Secretase Inhibitor III is an extremely selective BACE1 inhibitor (Ki = 0.13 nM).
DC47720 β-Secretase Inhibitor I β-Secretase Inhibitor I is an extremely potent β-secretase inhibitor with reduced cardiovascular and liver toxicity.
DC46492 BACE1-IN-5 BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 9.1 nM, and also inhibits cellular amyloid-β (Aβ) with an IC50 of 0.82 nM. BACE1-IN-5 has a medicinal chemistry that improves hERG inhibition and P-gp efflux.
DC46414 BACE-1 inhibitor 2 BACE-1 inhibitor 2 is a potent and CNS permeable BACE-1 inhibitor with an IC50 of 1.5 nM in BACE-1 enzymatic assay.
DC46382 β-Secretase Inhibitor II β-Secretase Inhibitor II is a β-Secretase inhibitor. β-Secretase Inhibitor II is a simple tripeptide aldehyde (IC50=700 nM for inhibition of total Aβ and IC50=2.5 μM for Aβ1–42). β-Secretase Inhibitor II can be used for the research of Alzheimer's disease.
DC46112 Cassiaside Cassiaside is a naphthopyrone glucoside, shows mixed-type inhibition against BACE1 (IC50=4.45 μM; Ki=9.85 μM). Cassiaside possesses potential anti- Alzheimer's disease (AD) activity.
DC40115 Kushenol C Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 μM.
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