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POL1 inhibitor(POL1-IN-1)

  Cat. No.:  DC10539   Featured
Chemical Structure
1822358-25-7
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Field of application
CAS 1822358-25-7
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1822358-25-7
Chemical Name: 2-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzo[4,5]imidazo[1,2-a][1,8]naphthyridine-6-carbonitrile
SMILES: N12C3=CC=CC=C3N=C1C(C#N)=CC1=C2N=C(N2C[C@H](C)N[C@H](C)C2)C=C1
Formula: C21H20N6
M.Wt: 356.42
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: POL1-IN-1 is a RNA polymerase 1 (POL1, also known as Pol I) inhibitor with an IC50 of less than 0.5 uM. POL1-IN-1 inhibits ribosome biogenesis by inhibiting POL1 transcription[1].
References: [1]. Mustapha Haddach. Compositions, uses and methods for making them. US9758518B2.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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