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Home > Inhibitors & Agonists > PI3K/Akt/mTOR > PI3K

3-Methyladenine

  Cat. No.:  DC7348   Featured
Chemical Structure
5142-23-4
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Field of application
3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 5142-23-4
Chemical Name: 3-Methyladenine
Synonyms: 3-METHYLADENINE;3H-Purin-6-amine,3-methyl-;3-MA;3-Methyl-3H-purin-6-amine;3-Methyladenine (3-MA);3-methylpurin-6-amine;6-?Amino-?3-?methylpurine;3-MA,6-Amino-3-methylpurine;6-Amino-3-methylpurine;3-Methyl-6-aminopurine;N3-Methyladenine;NSC 66389;3H-Purin-6-amine, 3-methyl-;3-Methyl-3H-adenine;ADENINE, 3-METHYL-;3-METHYL-3H-PURIN-6-YLAMINE;3-Methyladenine autophagy inhibitor;3mea;4aia;3-methyl-Adenine;NSC66389;1p7m;4ai5;Autophagy Inhibitor, 3-MA;NCIOpen2_000270;SCHEMB
SMILES: N1(C([H])([H])[H])C([H])=N/C(/C2=C1N=C([H])N2[H])=N\[H]
Formula: C6H7N5
M.Wt: 149.1533
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: 3-Methyladenine is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K.
In Vivo: 3-Methyladenine (1.5 mg/100 g, i.p.) treatment alleviates sodium taurocholate-induced severe acute pancreatitis (SAP) in rats at both 12 and 24 h. 3-Methyladenine inhibits autophagy of pancreatic acinar cells in sodium taurocholate-tnduced SAP. 3-Methyladenine also shows inhibitory effects on PI3K/Akt signaling pathway and NF-κB signaling pathway in sodium taurocholate-tnduced SAP[3].
In Vitro: 3-Methyladenine shows slight preference to binds to Vps34 in vitro, with an IC50 of 25 µM for Vps34 as compared with 60 µM for PtdIns3Kγ, and 3-Methyladenine (10 mM) can inhibit all PtdIns3Ks[1]. 3-Methyladenine (3-MA, 5 mM) suppresses autophagy in HeLa cells under both glucose-free conditions and normal conditions. 3-Methyladenine (2.5, 5 or 10 mM) induces caspase-dependent cell death in HeLa cells, and the death occurs independently of the inhibition of autophagy. Moreover, 3-Methyladenine (3-MA, 1 mM) significantly shortens the duration of nocodazole-induced-prometaphase arrest[2].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC5181 Voxtalisib Analogue Voxtalisib (SAR245409, XL765) Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR.
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DC10140 SF2523 SF2523 is a highly selective and potent inhibitor of PI3K and BRD4with IC50 values of 16 and 241 nM for PI3Kα and BD1, respectively.
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