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Home > RNA Delivery > PegGylated lipids

ALC-0159

  Cat. No.:  DC52020   Featured
Chemical Structure
1849616-42-7
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More than 5000 active chemicals with high quality for research!
Field of application
ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid). Formulations containing ALC-0159 have been used in the development of lipid nanoparticles (LNPs) for the delivery of mRNA-based vaccines.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1849616-42-7
Chemical Name: Poly(oxy-​1,​2-​ethanediyl)​, α-​[2-​(ditetradecylamino)​-​2-​oxoethyl]​-​ω-​methoxy-
Synonyms: ALC-0159;ALC 0159;ALC0159
SMILES: O=C(N(CCCCCCCCCCCCCCC)CCCCCCCCCCCCCC)COCCOC
Formula: (C2H4O)NC31H63NO2
Purity: >99%
Sotrage: -20°C, protect from light
Publication: Public Assessment Report Authorisation for Temporary Supply COVID-19 mRNA Vaccine BNT162b2 (BNT162b2 RNA) concentrate for solution for injection"" (PDF). Regulation 174. MHRA. 15 December 2020.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC40169 DMG-PEG2000 DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modific
DC58047 DSPE-PEG 2000 PEG2000-DSPE is used for creating micelles that are able to carry drugs with low solubility.
DC52020 ALC-0159 ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid). Formulations containing ALC-0159 have been used in the development of lipid nanoparticles (LNPs) for the delivery of mRNA-based vaccines.
DC67347 DMG-PEG 1000 (14:1) A methoxy-terminated PEG1000 functionalized with 1,2-dimyristoleoyl-sn-glycerol via an ether linkage. This compound may be used in the formulation of lipid nanoparticles (LNP's) for delivery applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
DC67161 MPEG-2000-DPPE Na DPPE-MPEG(2000) is a PEGylated form of 1,2-dipalmitoyl-rac-glycero-3-PE (DPPE). It has been used in the synthesis of anionic liposomes for drug redistribution and toxicity prevention.
DC67112 DPPE-PEG2000 DPPE-PEG2000 (16:0 PEG2000 PE) is a PEG-modified lipids. 16:0 PEG2000 PE can reduce the nonspecific adsorption of protein and prolong circulation time in vivo.
DC67111 18:1 PEG2000 PE 18:1 PEG2000 PE (18:1 PEG-PE) is a polyethyleneglycol/phosphatidyl-ethanolamine conjugate. 18:1 PEG2000 PE can be used for drug delivery.
DC60638 Acid-degradable PEG Lipid (ADP-2k) Acid-degradable PEG Lipid (ADP) composed of polyethylene glycol lipid is synthesized with the azido-acetal linker and used to generate RD-LNPs, which significantly improves the performance of LNP-mRNA complexes in vitro and in vivo.
DC65786 mPEG2000-DSPE mPEG2000-DSPE is used in COVID 19 mRNA vaccines. It is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . Formulations containing DSPE-MPEG(2000) have been used to prepare liposomes with long circulation time for the delivery of anticancer and antimalarial agents.. mPEG2000-DSPE has also been widely used as hydrophilic surface modifying agent for a variety types of hydrophobic nanoparticles, including recently reported lipid nanoparticle mRNA vaccines.
DC65770 DMPE-mPEG2000(Na salt)
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