| Cas No.: | 2035509-96-5 |
| Synonyms: | AX15836; AX 15836; AX-15836 |
| SMILES: | O=C1C2=CC=CC=C2N(S(=O)(C)=O)C3=NC(NC4=CC=C(C(N5CCC(N6CCN(C)CC6)CC5)=O)C=C4OCC)=NC=C3N1C |
| Formula: | C32H40N8O5S |
| M.Wt: | 648.78 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Potent and selective ERK5 inhibitor (IC50 = 8 nM). Exhibits >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Also exhibits selectivity over bromodomain BRD4 (Kd = 3,600 nM). Increases vomocytosis in human macrophages in vitro, as well as in an in vivo zebrafish model of cryptococcal disease, reducing spread of infection. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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