AZ-628|AZ628,AZ 628|DC Chemicals|Price|Buy

Cas No.:	878739-06-1
Chemical Name:	AZ 628
Synonyms:	3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide;AZ 628;3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide;AZ-628;3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]-benzamide;3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide (ACI);GTPL8475;BRD-K05804044-001-06-0;CHEBI:91354;DTXSID70236677;3-(2-cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxoquinazolin-6-yl)amino)phenyl)benzamide;HMS3265I12;BDBM50430022;CHEMBL2144069;NCGC00250380-03;s2746;SW219448-1;BCP02117;3-(1-cyano-1-methylethyl)-N-{4-methyl-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl}benzamide;ZGBGPEDJXCYQPH-UHFFFAOYSA-N;DTXCID00159168;HMS3265I11;1007871-84-2;3-(1-Cyano-1-methylethyl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide;BRD-K05804044-001-09-4;HMS3656F21;BRD-K05804044-001-14-4;3-(Cyano-dimethyl-methyl)-N-[4-methyl-3-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylamino)-phenyl]-benzamide;3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide;AKOS016011304;DB-365376;3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]benzamide;BCP9000346;B1E;HMS3265J12;SDCCGSBI-0654462.P001;560S6B5D79;CCG-264992;HY-11004;CS-0091;AZD628;SMR004701380;SCHEMBL4209241;BRD-K05804044-001-01-1;MFCD17392577;SB19421;BRD-K05804044-001-12-8;BS-42436;EX-A302;MLS006010314;3-(2-Cyanopropan-2-Yl)-N-{4-Methyl-3-[(3-Methyl-4-Oxo-3,4-Dihydroquinazolin-6-Yl)amino]phenyl}benzamide;878739-06-1;NSC782007;HMS3265J11;J-510421;HMS3743G19;NCGC00250380-01;Q27074677;AC-26863;AZ628;Benzamide, 3-(1-cyano-1-methylethyl)-N-(3-((3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino)-4-methylphenyl)-;NCGC00250380-10;UNII-560S6B5D79;NSC-782007
SMILES:	N#CC(C)(C)C1C=C(C(NC2C=C(NC3C=C4C(N=CN(C)C4=O)=CC=3)C(C)=CC=2)=O)C=CC=1
Formula:	C₂₇H₂₅N₅O₂
M.Wt:	451.519705533981
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM For c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity For Raf kinases over a panel of 150 other kinases; inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Also inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.For the detailed information of AZD-628, the solubility of AZD-628 in water, the solubility of AZD-628 in DMSO, the solubility of AZD-628 in PBS buffer, the animal experiment (test) of AZD-628, the cell expriment (test) of AZD-628, the in vivo, in vitro and clinical trial test of AZD-628, the EC50, IC50,and Affinity of AZD-628, Please contact DC Chemicals.

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2018-0101

Cat. No.	Product name	Field of application
DC71910	Tinlorafenib	Tinlorafenib (PF-07284890) (compound 10) is an orally active BRAF kinase inhibitor, with IC50s of 4.25 and 2.7 nM for BRAFV600E/V600K respectively. Tinlorafenib demonstrates CNS penetration and can be used in the research of BRAF-associated malignant and benign tumors of the CNS as well as extracranial malignancies[1].
DC71909	Exarafenib	Exarafenib (RAF/KIN_2787) is a potent, orally active pan-RAF inhibitor. Exarafenib has anticancer activity by suppression of downstream MAPK pathway signaling. Exarafenib can be used for cancer research.
DC70702	PLX8394	PLX8394 (PLX-8394) is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF (V600E), WT BRAF and CRAF, respectively.PLX8394 suppresses mutant BRAF cells without activating the MAPK pathway in cells bearing upstream activation, overcame several known mechanisms of resistance to first-generation RAF inhibitors.PLX8394 inhibits ERK signaling by specifically disrupting BRAF-containing dimers, including BRAF homodimers and BRAF-CRAF heterodimers, but not CRAF homodimers or ARAF-containing dimers.As a BRAF-specific dimer breaker, PLX8394 selectively inhibits ERK signaling in tumors driven by dimeric BRAF mutants, including BRAF fusions and splice variants as well as BRAF V600 monomers, but spares RAF function in normal cells in which CRAF homodimers can drive signaling.
DC39085	Donafenib (Sorafenib D3)	Sorafenib D3 (Bay 43-9006 D3) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 15 nM, 20 nM and 22 nM for Raf-1, mVEGFR-2, mVEGFR-3 and B-RAF, respectively.
DC7370	AZ-628	Potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM For c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity For Raf kinases over a panel of 150 other kinases.
DC8727	PF-04880594	PF-04880594 is an inhibitor of RAF with IC50 values of 0.19 nM/0.13 nM and 0.39 nM for BRAF/BRAFV599E and c-RAF, respectively.
DC12278	Belvarafenib	Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.