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A-1210477

  Cat. No.:  DC8475   Featured
Chemical Structure
1668553-26-1
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More than 5000 active chemicals with high quality for research!
Field of application
A-1210477 is a potent and selective MCL-1 inhibitor.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1668553-26-1
Chemical Name: mc1 Inhibitor
Synonyms: 7-(1,3-Dimethyl-5-((4-(4-(methylsulfonyl)piperazin-1-yl)phenoxy)methyl)-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid;7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid;A-1210477;mc1 Inhibitor;AOB5551;BCP15988;BDBM50078163;s7790;AK328301;7-(5-((4-(4-(N,N-Dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,;7-[5-[[4-[4-(Dimethylsulfamoyl)piperazin-1-yl]phenoxy]methyl]-1,3-dimethylpyrazol-4-yl]-1-(2-morphol
SMILES: S(N(C([H])([H])[H])C([H])([H])[H])(N1C([H])([H])C([H])([H])N(C2C([H])=C([H])C(=C([H])C=2[H])OC([H])([H])C2=C(C(C([H])([H])[H])=NN2C([H])([H])[H])C2=C([H])C([H])=C([H])C3C(C([H])([H])C([H])([H])C([H])([H])OC4=C([H])C([H])=C([H])C5=C([H])C([H])=C([H])C([H])=C45)=C(C(=O)O[H])N(C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C=32)C([H])([H])C1([H])[H])(=O)=O
Formula: C46H55N7O7S
M.Wt: 850.0366
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A-366 is a potent histone methyltransferase G9a inhibitor with an IC50 of 3.3 nM.
References: [1]. Pappano WN, et al. The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia.PLoS One. 2015 Jul 6;10(7):e0131716.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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