A 804598
Cat. No.: DC9954
Featured
Chemical Structure
1125758-85-1
We are official vendor of:
More than 5000 active chemicals with high quality for research!
Field of application
A-804598 is a novel, competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively.
| Cas No.: |
1125758-85-1 |
| Chemical Name: |
N-Cyano-N''-[(1s)-1-phenylethyl]-N'-5-quinolinyl-guanidine |
| Synonyms: |
A 804598;2-Cyano-1-[(1S)-1-phenylethyl]-3-(5-quinolinyl)guanidine;A-804598;N-Cyano-N′′-[(1S)-1-phenylethyl]-N′-5-quinolinyl-guanidine;A804598;N-cyano-N''-[(1s)-1-phenylethyl]-N'-5-quinolinyl-guanidine;1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine;GTPL4121;AOB1737;HMS3886P12;BCP19303;BDBM50237707;BDBM50298708;s8725;Q27074085;(S)-2-cyano-1-(1-phenylethyl)-3-(quinolin-5-yl)guanidine;1-cyano-2-[(1S)-1-phenylethyl]-3-(quinolin-5-yl)guanidine;1-cyano-2-[(1S)-1- |
| SMILES: |
N([H])(/C(/N([H])C#N)=N/[C@@]([H])(C([H])([H])[H])C1C([H])=C([H])C([H])=C([H])C=1[H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=N2 |
| Formula: |
C19H17N5 |
| M.Wt: |
315.3718 |
| Sotrage: |
4°C for 1 year, -20°C for more than 2 years |
| Description: |
A-804598 is a novel, competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively. |
| In Vivo: |
Autoradiographic analysis of coronal rat brain sections revealed that there was specific binding of [3H]-A-804598 throughout the rat brain. High levels of [3H]-A-804598 specific binding were also found in the grey matter of the L4-L6 region of the rat spinal cord. [2] |
| In Vitro: |
A-804598 potently blocked IL-1β release in the THP-1 cells (IC50 of 8.5 nM). A-804598 also blocked agonist-evoked pore formation in differentiated human THP-1 cells (IC50 of 8.1 nM) with similar potency as in the calcium-influx assay. [1] |
MSDS
COA
| LOT NO. |
DOWNLOAD |
|
|
| 2018-0101 |
|
| 2018-0101 |
|
Get Quote
