ALLM (Ac-Leu-Leu-Met-CHO)
Cat. No.: DC29240
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Chemical Structure
145757-50-2
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Field of application
A potent, cell-permeable calpain inhibitor with Ki of 0.6 and 100 nM for calpain L and calpain B, respectively; inhibits the activities of Ca(2+)-dependent neutral proteases as well as lysosomal proteases, including cathepsin L, cathepsin B, and cathepsin D; induce apoptosis in rat pituitary tumor cells by specific caspase activation.
| Cas No.: |
145757-50-2 |
| Chemical Name: |
(2S)-2-Acetamido-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]-4-methyl-N-[(2S)-1-oxo-4-sulfanylbutan-2-yl]pentanamide |
| Synonyms: |
(S)-N-ACETYL-L-LEUCYL-N-(1-FORMYL-3-MERCAPTOPROPYL)-L-LEUCINAMIDE;N-Acetyl-L-leucyl-L-leucyl-L-methional;(2S)-2-Acetamido-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]-4-methyl-N-[(2S)-1-oxo-4-sulfanylbutan-2 |
| SMILES: |
SCC[C@@H](C=O)N(C([C@H](CC(C)C)NC(C)=O)=O)[C@H](C(N)=O)CC(C)C |
| Formula: |
C18H33N3O4S |
| M.Wt: |
387.537323713303 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
A potent, cell-permeable calpain inhibitor with Ki of 0.6 and 100 nM for calpain L and calpain B, respectively; inhibits the activities of Ca(2+)-dependent neutral proteases as well as lysosomal proteases, including cathepsin L, cathepsin B, and cathepsin D; induce apoptosis in rat pituitary tumor cells by specific caspase activation. |
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